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91.
目的:对19 例鼻咽部B细胞性恶性淋巴瘤与EB 病毒(EpsteinBarr virus,EBV) 感染的相关性进行研究。方法:利用免疫组织化学及原位杂交方法对EBV 进行检测,并用免疫组化及原位杂交双染法标记肿瘤细胞,以鉴定EBV阳性的细胞为B淋巴瘤细胞。结果:EBV 编码的小m RNA探针(EBER) 原位杂交显示,8 例原发性鼻咽部B细胞性恶性淋巴瘤中3 例绝大多数肿瘤细胞呈阳性表达,1 例潜在性膜蛋白1(latent membrane protein 1,LMP1)阳性。而11 例继发性鼻咽部B细胞性恶性淋巴瘤EBER全部为阴性。全部病例进行了LMP1 检测,除1 例原发者,全部阴性。利用EBERISH(EBER原位杂交) 和免疫组化CD 标记物进行双标记染色证实,EBER 和LMP1阳性细胞为CD20 阳性,CD45RO 阴性。鼻咽部原发性B细胞性恶性淋巴瘤EBV 表达4/8 ,而继发者为0/11。结论:EBV 与鼻咽部原发性B细胞恶性淋巴瘤有较高的相关性,而与继发性者无关。 相似文献
92.
H. J. SCHMOLL I. SCHUBERT H. ARNOLD G. DÖLKEN Th. HECHT L. BERGMANN J. ILLIGER U. FINK J. PREISS M. PFREUNDSCHUH H. KAULEN B. BONFERT A. D. HO C. MANEGOLD A. MAYR L. HOFFMANN J. WEISS H. HECKER 《International journal of andrology》1987,10(1):311-317
This is a preliminary analysis of the AIO-Testicular Tumour Study Group trial in patients with disseminated bulky testicular cancer. Treatment plan: cisplatin 35 mg/m2 days 1-5, VP-16 120 mg/m2 days 1-5 (two daily divided doses), bleomycin 15 mg/m2 days 1, 8, 15. Of 98 patients at present evaluable 63% had complete remission or have no evidence of disease (CR/NED), 30% had partial remission (PR) and 7% had no change or progressive disease (NC/P). Relapse-free survival is 93% for the CR/NED group after a median follow up of 2.2 years: the overall survival for the entire patient population is 70%. Toxicity included predominantly granulocytopenic fever and infection with septicaemia, thrombocytopenia, nausea, vomiting, neurotoxicity and lung toxicity, with 7% fatal toxicity. A prospective randomized trial is warranted to evaluate the apparent superior activity of ultra high dose cisplatin in combination with VP-16 and bleomycin. 相似文献
93.
目的:采用自固定式显微椎间盘镜系统治疗腰椎间盘突出症。方法:从2000年10月采用自固定式显微核间盘镜髓核摘除术共治疗44例腰椎间盘突出症,其中男28例,女16例,年龄22-71岁(平均39.6岁),病程4个月至8年,平均16.4个月。结果:本组经3-10个月随访,优:31例;良:7例;优良率86.4%,可6例。3例出现硬膜囊撕裂,脑脊液漏,1例出现马尾神经损伤引起下肢局部麻木,均发生在早期手术病全,随着临床经验的积累,目前未发生类似并发症,未见椎间盘隙感染的发生。结论:自固定式显微椎间盘镜系统具有手术创伤小,容易操作,术后恢复快的特点,最适用于单侧单节段的椎间盘突出症,伴或不伴有椎管狭窄的病例。 相似文献
94.
Tae Young Yoon Seok KI Jung & Seung HO Chang 《The British journal of dermatology》1998,139(5):885-888
A case of severe photosensitivity in a girl with the Smith–Lemli–Opitz syndrome is reported. Children with this recessively inherited metabolic disorder of cholesterol metabolism present with a variety of congenital abnormalities of the nervous system and internal organs in association with varying degrees of mental retardation. Photosensitivity is a feature which has previously only briefly been mentioned in the literature in association with this syndrome. However, more recently, it has become apparent that photosensitivity is not uncommon among children with the Smith–Lemli–Opitz syndrome, although the nature of the photosensitivity in these patients has remained undefined. Our patient has suffered from sunlight intolerance since early infancy, with redness and pruritus of sun-exposed skin developing within minutes of sun exposure. Monochromator ultraviolet (UV) radiation and visible light testing revealed an immediate and persistent reaction to low-dose UVA at 350 nm, and an abnormal erythemal response to visible light at 400 nm. 相似文献
95.
96.
The level of seminal leucocytes and the prevalence of leucocytospermia was determined in a group of fertile and infertile southern Chinese men in Hong Kong. Sixteen normal fertile semen donors and 49 men with male factor infertility were studied prospectively. None had antisperm antibodies and past or present evidence of genital tract infection. Seminal leucocytes and their subsets were analysed using monoclonal antibodies and an immunocytochemical alkaline phosphatase-anti-alkaline phosphatase conjugate technique. Seminal leucocytes were detectable in 94% and 86% of the fertile and infertile men respectively, with the predominant subset being granulocytes. Leucocytospermia (> 1 × 106 leucocytes/ml) was found in only one of the 49 (2%) infertile men without clinical evidence of genito-urinary infection. Inverse correlations were observed between (1) the percentage of spermatozoa with normal morphology and the number of T-helper/inducer cells, (2) the linearity of sperm movement and the number of T-lymphocytes. In conclusion, the level of seminal leucocytes and the prevalence of leucocytospermia is low in infertile Chinese subjects. The effect of seminal leucocytes on sperm function in these subjects needs further evaluation. 相似文献
97.
Asthma epidemiology in the Far East 总被引:8,自引:3,他引:5
98.
Intratesticular varicocele is a rare entity and its clinical significance is not well established. We report a case of left-sided intratesticular varicocele associated with a significant reduction in left testicular volume at follow up. This association has not been previously reported. Incidentally, our patient is also the youngest case reported in the literature to date. 相似文献
99.
H-J. HARN L-I. HO C-A. LIU G-C. LIU F-G. LIN J-J. LIN J-Y. CHANG & W-H. LEE 《Histopathology》1996,28(4):317-323
High levels of bcl-2 protein have been found in a wide variety of human cancers. Since p53 gene inactivation occurs in over half of human cancers, it is possible that loss of p53-mediated repression of bcl-2 gene expression accounts, at least in part, for the frequent abnormalities in bcl-2 protein production seen in tumours. By using immunohistochemical methods, we have analysed thirty-three nasopharyngeal carcinomas for p53 and bcl-2 expression. We found an inverse correlation between the expression of these two proteins ( P < 0.001). Moreover, we utilized universal oligonucelotide primers of a region 5' to the bcl-2 MBR and at the 3' end of JH segments to initiate a DNA polymerase chain reaction that amplified these bcl-2-JH junctures. Of the twelve nasopharyngeal carcinomas expressing bcl-2, none showed a t(14;18) chromosome translocation. These findings may indicate potential mechanisms by which bcl-2 regulates apoptosis. 相似文献