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101.
Tara Dahn Patrick T.Fok Hana Wiemer Daniel J.Dutton Valancy Cole David Lewis Tong Liu Keith R. Brunt Robert Hanlon Jacqueline Fraser Chris Vaillancourt Paul Atkinson 《世界急诊医学杂志(英文)》2023,14(1):62-64
<正>Multiple studies have reported decreased emergency department(ED) patient volumes during the coronavirus disease(COVID-19) pandemic,[1-6] including areas most affected by the virus.[7]Most existing studies have investigated general trends in ED presentations and have not examined the impact of COVID-19 on different types of EDs, specific ED patient groups, or illness presentations. 相似文献
102.
Rocio K. Finol-Urdaneta Rebekah Ziegman Zoltan Dekan Jeffrey R. McArthur Stewart Heitmann Karen Luna-Ramirez Han-Shen Tae Alexander Mueller Hana Starobova Yanni K.-Y. Chin Joshua S. Wingerd Eivind A. B. Undheim Ben Cristofori-Armstrong Adam P. Hill Volker Herzig Glenn F. King Irina Vetter Lachlan D. Rash David J. Adams Paul F. Alewood 《Proceedings of the National Academy of Sciences of the United States of America》2022,119(5)
103.
Richard C. Baybutt Joseph T. Standard Daniel Dim Tim Quinn Hana Hamdan Dingbo Lin Kyle Kunz Zachary S. Bomstein Benjamin J. Estorge Betty Herndon Hamid Zia Ahmad Mansour Manesha Lankachandra Agostino Molteni 《Nutrients》2022,14(3)
Vitamin A plays a prominent role for maintaining optimal bone status, but its impact upon the bone in response to vitamin A deficiency is not well defined. The purpose of this study was to evaluate how replenishing vitamin A by either whole food cod liver oil (COD) or the active metabolite of vitamin A, retinoic acid (RA), altered bone thickness of vitamin A-deficient (VAD) rats. Weanling rats were administered a control diet (CTRL) or VAD diet for 9 weeks. This was followed by four weeks of treatment in which the VAD group was divided into the following 4 subgroups: (1) VAD (9 weeks)-VAD (4 weeks); (2) VAD-CTRL; (3) VAD-COD; and (4) VAD-RA. Compared to controls, VAD rats had thicker bones which showed marked dysplasia. VAD-rats treated with COD produced a thinner bone that was not significantly different from that of untreated rats. In contrast, RA did not significantly change the thicker bone, and also had significantly greater periosteal and endosteal osteoblast numbers compared to VAD-COD. Active osteoclasts were not detected in VAD rats, nor during the treatment period. These findings suggest that the abnormal bone thickness in VAD rats appears to be more effectively restored to bone thickness of untreated control rats when treated with COD. 相似文献
104.
Hana Tahaei Florence Gignac Ariadna Pinar Silvia Fernandez-Barrs Dora Romaguera Jesus Vioque Loreto Santa-Marina Mikel Subiza-Prez Sabrina Llop Raquel Soler-Blasco Victoria Arija Jordi Salas-Salvad Adonina Tardn Isolina Riao-Galn Jordi Sunyer Monica Guxens Jordi Julvez 《Nutrients》2022,14(3)
Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child’s neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children’s Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: −22.95, −0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings. 相似文献
105.
Kateřina Kamarádová Hana Vošmiková Kateřina Rozkošová Aleš Ryška Ilja Tachecí Jan Laco 《Pathology, research and practice》2019,215(4):730-737
Background
Patients with inflammatory bowel disease (IBD) – ulcerative colitis (UC) and Crohn’s disease (CD) have an elevated risk of developing colorectal carcinoma (CRC). Major risk factor in IBD patients is the continuous chronic inflammation leading to development of dysplasia and carcinoma. Nevertheless, other types of non-conventional but suspicious mucosal changes serrated change/dysplasia, NOS and villous hypermucinous change, have also been reported in IBD patients. Preneoplastic potential of these lesions is still not well elucidated.Aims
The aim of this study was identification of IBD-associated CRCs focusing on finding related precursor lesions in the surgical specimen or in archival biopsy samples followed by a detailed morphological, immunohistochemical and molecular evaluation. For the purpose of the study the mucosal lesions were divided into conventional IBD-associated dysplasia and non-conventional lesions that were merged under a provisory term of putative preneoplastic lesions (PPL).Methods
A total of 309 consecutive IBD colectomy specimens diagnosed during a 10-year period were reviewed. Detailed morphological evaluation, immunohistochemical analysis of mismatch repair (MMR) proteins, p53 and O6-methylguanine DNA methyltransferase (MGMT) expression and molecular analysis for KRAS, NRAS and BRAF gene mutation were performed in the retrieved CRC cases as well as in the detected dysplasia and PPLs of these patients.Results
We identified 11 cases of morphologically heterogenous IBD-associated CRCs, occurring in 5 males and 6 females, aged 26–79 years (mean 44 years). A total of 22 mucosal lesions were revealed in 8 CRC patients comprising conventional IBD-associated dysplasia (4 lesions), PPLs as serrated change/dysplasia NOS (11 lesions), villous hypermucinous change (5 lesions), and two true serrated lesions (one sessile serrated adenoma and one traditional serrated adenoma). More than one type of lesion was found in 6 patients. Seven CRC cases harbored mutation of KRAS/NRAS and one case of BRAF. Two patients with KRAS-mutated CRC showed the same mutation in PPL in the same specimen (one serrated change NOS and one TSA with high-grade dysplasia). Similarly, one BRAF-mutated carcinoma case presented the same mutation in serrated change/dysplasia, NOS in the same specimen. Of the CRCs, two showed deficient MMR system profile, six presented with loss of MGMT expression, and six showed aberrant p53 expression. PPLs showed deficient MGMT expression (14 cases) and aberrant p53 (10 cases) as well.Conclusion
IBD-associated CRCs are very heterogeneous entities. Besides conventional IBD-related dysplasia, other types of mucosal lesions may be associated with long lasting IBD and CRC e.g. villous hypermucinous change and serrated change/dysplasia, NOS. Since these lesions share certain genetic or immunohistochemical changes with the related CRC, a suspicion is raised that these lesions may also have preneoplastic potential. Awareness of these changes is necessary to prevent their missing and under-reporting, and further studies of these lesions should be carried out. 相似文献106.
One hundred forty-two female Ss divided into repressors and sensitizers by their median score on the R-S scale received either a favorable or an unfavorable evaluation of themselves, both discrepant at a similar degree from their own self-evaluation. Sensitizers, in comparison to repressors, exhibited greater adoption of the negative evaluation and acceptance of its source, but less acceptance of the positive evaluation and its source. These results were explained as providing support for the contention that repressors and sensitizers differ in their willingness to assign negative vs. positive qualities to one's self and to endorse internal conflict rather than in their choice of defense mechanisms in the face of threatening information. 相似文献
107.
Petr Kanovsky Dagmar Kubová Martin Bares Hana Hortová Hana Streitová Ivan Rektor Vladimír Znojil 《Movement disorders》2002,17(1):188-191
Twelve patients with levodopa-induced dyskinesias were treated with continuous subcutaneous apomorphine. A markedly significant reduction in peak dose dyskinesias occurred over a two-year follow-up. 相似文献
108.
109.