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941.
Salman Zafar Faiz -Ur-Rehman Zafar Ali Shah Abdur Rauf Aziz Khan Muhammad Humayun Khan 《Journal of Asian natural products research》2019,21(7):679-687
Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of Olea ferruginea stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan (1) and a known compound (+)- cycloolivil (2). The structures of 1 and 2 were determined by various spectroscopic techniques and were assayed for their in vitro antibacterial and leishmanicidal potential. Compound 1 showed 75% inhibition after 24 h of incubation and 98% inhibition after 48 h of incubation against Leishmania tropica KWH23 promastigotes at 100 μg/mL concentration, while compound 2 exhibited 73% and 96% inhibition at the same concentration and incubation time. Compound 1 also showed good activity against various bacterial pathogens. 相似文献
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T Imran L Zafar M Rehan A Nasir PA Tariq I Batool 《Journal of the College of Physicians and Surgeons--Pakistan : JCPSP》2012,22(8):539-541
Chediak-Higashi Syndrome (CHS) is a rare autosomal recessive disorder, characterized by silver hair, recurrent infections, partial oculo-cutaneous albinism, mild coagulation defect and progressive neuropathy. The characteristic feature of CHS is the presence of huge lysosomes and cytoplasmic inclusions within different body cells like the white blood cells. The disease has an early onset but usually presents in an accelerated phase. We present a case of a 2 years old boy with high grade fever, bilateral cervical lymphadenopathy, hepatosplenomegaly, abdominal distention of 28 days duration. He was diagnosed with Chediak-Higashi syndrome in accelerated phase on the basis of clinical presentation, morphological findings on peripheral blood film and bone marrow aspirate. 相似文献
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Helen L. Scott Francesco Tamagnini Katherine E. Narduzzo Joanna L. Howarth Youn‐Bok Lee Liang‐Fong Wong Malcolm W. Brown Elizabeth C. Warburton Zafar I. Bashir James B. Uney 《The European journal of neuroscience》2012,36(7):2941-2948
Evidence suggests that the acquisition of recognition memory depends upon CREB‐dependent long‐lasting changes in synaptic plasticity in the perirhinal cortex.The CREB‐responsive microRNA miR‐132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR‐132 selectively in the rat perirhinal cortex and demonstrated impairment in short‐term recognition memory. This functional deficit was associated with a reduction in both long‐term depression and long‐term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience‐dependent changes in the brain. In addition, these results demonstrate a role for miR‐132 in the neuronal mechanisms underlying the formation of short‐term recognition memory. 相似文献
948.
Chigbu DeGaulle I. Jain Pooja Crumley Brenndan L. Patel Dip Khan Zafar K. 《Journal of neurovirology》2019,25(3):289-300
Journal of NeuroVirology - Human T cell leukemia virus type 1 (HTLV-1) and Zika virus (ZIKV) have been considered neglected viruses of low public health concern until recently when incidences of... 相似文献
949.
Maham Israr Nadia Naseem Tasleem Akhtar Usman Aftab Muhammad Shoaib Zafar Muhammad Asif Faheem Muhammad Shahzad 《Phytotherapy research : PTR》2023,37(3):903-912
Nimbolide is an active constituent of Azadirachta indica and is known for its anti-inflammatory, anti-oxidant, immune-modulatory, and anti-cancer effects. Few studies suggest that nimbolide treatment influences the responses to rheumatoid arthritis, but the underlying molecular mechanisms involved are not yet well established. Therefore, the present study was designed to determine the effect of nimbolide on expression regulation of toll-like receptors to attenuate rheumatoid arthritis. The rheumatoid arthritis model was established by injecting complete Freund's adjuvant (CFA) intra-dermally into the sub-plantar region of the left hind paw of rats. Nimbolide (20 mg/kg) and piroxicam (10 mg/kg) were given to arthritic rats. Rats treated with nimbolide showed a significant reduction in inflammatory cells, rheumatoid factor, ESR, and improved the body weight. The results indicated that nimbolide possesses the capacity to attenuate rheumatoid arthritis by downregulating toll-like receptors, IL-17, IL-23, HSP70, and IFN-γ expression levels. Nimbolide treatment showed significant reduction in the severity of inflammation and destruction of joints and showed comparable effects to piroxicam, which is a standard non-steroidal anti-inflammatory drug used for the treatment of rheumatoid arthritis. It can be concluded that nimbolide can be considered as a potential candidate for therapeutic targeting of the toll-like receptors pathway in rheumatoid arthritis. 相似文献
950.
Arshad Muhammad Sohail Zahra Aleema Tehreem Zafar Saman Zaman Hussain Akhtar Ambreen Ayaz Muhammad Mazhar Kucuk Israfil Maniruzzaman Mohammed Chang Ming-Wei Ahmad Zeeshan 《Pharmaceutical research》2021,38(1):165-177
Pharmaceutical Research - The aim of this study was to fabricate polymeric microneedles, loaded with macrolides (erythromycin, azithromycin), using hyaluronic acid and polyvinyl pyrollidone. These... 相似文献