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631.
Martin Klietz MD Nima Mahmoudi MD Andrew A. Maudsley PhD Sulaiman Sheriff Paul Bronzlik MD Mohammad Almohammad MD Patrick Nösel PhD Florian Wegner MD Günter U. Höglinger MD Heinrich Lanfermann MD Xiao-Qi Ding MD PhD 《Movement disorders》2023,38(8):1503-1514
Background
Progressive supranuclear palsy (PSP) is an atypical Parkinsonian syndrome characterized by supranuclear gaze palsy, early postural instability, and a frontal dysexecutive syndrome. Contrary to normal brain magnetic resonance imaging in Parkinson's disease (PD), PSP shows specific cerebral atrophy patterns and alterations, but these findings are not present in every patient, and it is still unclear if these signs are also detectable in early disease stages.Objective
The aim of the present study was to analyze the metabolic profile of patients with clinically diagnosed PSP in comparison with matched healthy volunteers and PD patients using whole-brain magnetic resonance spectroscopic imaging (wbMRSI).Methods
Thirty-nine healthy controls (HCs), 29 PD, and 22 PSP patients underwent wbMRSI. PSP and PD patients were matched for age and handedness with HCs. Clinical characterization was performed using the Movement Disorder Society Unified Parkinson's Disease Rating Scale, PSP rating scale, and DemTect (test for cognitive assessment).Results
In PSP patients a significant reduction in N-acetyl-aspartate (NAA) was detected in all brain lobes. Fractional volume of the cerebrospinal fluid significantly increased in PSP patients compared to PD and healthy volunteers.Conclusions
In PSP much more neuronal degeneration and cerebral atrophy have been detected compared with PD. The most relevant alteration is the decrease in NAA in all lobes of the brain, which also showed a partial correlation with clinical symptoms. However, more studies are needed to confirm the additional value of wbMRSI in clinical practice. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献632.
Sarra Laabidi Asma Ben Mohamed Amal Khsiba Manel Yakoubi Moufida Mahmoudi Mouna Medhioub Lamine Hamzaoui Mohamed Mssadak Azouz 《Clinical Case Reports》2022,10(3)
We present the case of a 65‐year‐old man without a past medical history who was admitted for gastrointestinal bleeding. The case shows an acquired double pylorus due to probable pre pyloric ulcer. 相似文献