全文获取类型
收费全文 | 879篇 |
免费 | 29篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 54篇 |
妇产科学 | 10篇 |
基础医学 | 62篇 |
口腔科学 | 36篇 |
临床医学 | 137篇 |
内科学 | 215篇 |
皮肤病学 | 23篇 |
神经病学 | 5篇 |
特种医学 | 244篇 |
外科学 | 42篇 |
综合类 | 29篇 |
预防医学 | 22篇 |
眼科学 | 14篇 |
药学 | 44篇 |
肿瘤学 | 34篇 |
出版年
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 14篇 |
2014年 | 12篇 |
2013年 | 21篇 |
2012年 | 9篇 |
2011年 | 6篇 |
2010年 | 27篇 |
2009年 | 38篇 |
2008年 | 12篇 |
2007年 | 54篇 |
2006年 | 21篇 |
2005年 | 16篇 |
2004年 | 9篇 |
2003年 | 6篇 |
2002年 | 14篇 |
2001年 | 14篇 |
2000年 | 10篇 |
1999年 | 14篇 |
1998年 | 61篇 |
1997年 | 70篇 |
1996年 | 70篇 |
1995年 | 59篇 |
1994年 | 42篇 |
1993年 | 49篇 |
1992年 | 10篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 40篇 |
1988年 | 24篇 |
1987年 | 36篇 |
1986年 | 12篇 |
1985年 | 25篇 |
1984年 | 15篇 |
1983年 | 23篇 |
1982年 | 19篇 |
1981年 | 17篇 |
1980年 | 20篇 |
1979年 | 1篇 |
1978年 | 5篇 |
1977年 | 9篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1966年 | 2篇 |
1948年 | 1篇 |
1947年 | 1篇 |
排序方式: 共有973条查询结果,搜索用时 15 毫秒
881.
882.
883.
884.
885.
886.
Objective : Childhood obesity is an emerging problem in Asia. Sequential monitoring of the growth of an individual can detect a change in body fatness, provided there are ethnically appropriate growth references.
Methodology : A territory wide cross-sectional growth survey of Hong Kong on 24 709 individuals from the age of newborn to 18 years was performed in 1993. Weight-for-age and weight-for-height percentile charts were prepared separately for boys and girls.
Results : There was an average increase of 8.5 kg and 5.1 kg in the 18 year old boys and girls, respectively, compared to those surveyed 30 years ago. The percentile curves between 6 and 18 years were similar to those of Singapore. Weight-for-height percentile curves were close to those of America in the prepubertal years.
Conclusions : These Hong Kong growth standards for weight-for-age and weight-for-height are important tools for the assessment of nutritional status of an individual and for monitoring changes in nutritional status of the population. 相似文献
Methodology : A territory wide cross-sectional growth survey of Hong Kong on 24 709 individuals from the age of newborn to 18 years was performed in 1993. Weight-for-age and weight-for-height percentile charts were prepared separately for boys and girls.
Results : There was an average increase of 8.5 kg and 5.1 kg in the 18 year old boys and girls, respectively, compared to those surveyed 30 years ago. The percentile curves between 6 and 18 years were similar to those of Singapore. Weight-for-height percentile curves were close to those of America in the prepubertal years.
Conclusions : These Hong Kong growth standards for weight-for-age and weight-for-height are important tools for the assessment of nutritional status of an individual and for monitoring changes in nutritional status of the population. 相似文献
887.
Cell-lineage antigens of the stem cell-megakaryocyte-platelet lineage are associated with the platelet IIb-IIIa glycoprotein complex 总被引:5,自引:2,他引:3
The stem cell-platelet lineage is uniquely defined by platelet cell- lineage antigens. These antigens are present on all stem cells measured by the spleen colony assay and become restricted to the platelet cell lineage as differentiation proceeds. In this study, anti-platelet serum (APS) has been used to identify cells in the bone marrow that express platelet cell-lineage antigens and to identify platelet cell surface molecules expressing these antigens. Anti-platelet IgG extensively absorbed with brain, thymus, and peritoneal cells bound selectively to stem cells, megakaryocyte progenitor cells (Mk-CFC), and megakaryocytes in CBA mouse bone marrow and to blood platelets. No other hemopoietic cell type, tissue, cell line, or tumor cell bound significant amounts of antibody against platelet cell-lineage antigens as determined by ability to absorb the anti-stem cell activity in APS. Studies with lactoperoxidase-labeled platelets showed that two major iodinated proteins of Mr = 114,000 and 138,000 were immunoprecipitated with APS and with antiserum that had been extensively absorbed. These proteins correspond to the platelet IIb-IIIa glycoprotein complex, which is known to express receptors for collagen and fibrinogen, molecules known to influence hemopoietic cell proliferation and tumor cell growth. A panel of six monoclonal antibodies against human IIb-IIIa inhibited spleen colony formation by 17% to 100%, J15 and A5.15 also being cytotoxic for granulocyte-macrophage progenitor cells and Mk-CFC. Other platelet monoclonal antibodies did not inhibit spleen colony formation. Although APS inhibited fibrinogen binding to platelets and platelet aggregation, these activities were greatly reduced with absorbed antiserum. Furthermore, fibrinogen treatment of bone marrow did not block the anti-stem cell activity in APS. Thus the evidence is consistent with expression of platelet cell-lineage antigens on the platelet IIb-IIIa glycoprotein complex at a site removed from the fibrinogen binding site. 相似文献
888.
889.
SS LEUNG KS STEINBECK SL MORRIS MR KOHN SJ TOWNS DL BENNETT 《Journal of paediatrics and child health》1997,33(2):107-112
To describe the inter-relationship of chronic illness severity as perceived by adolescents with both psychosocial well-being and objective measures of illness severity. Additionally to compare the adolescents' perception of illness severity with how their physicians believe that the adolescents perceive their illness severity.
The psychological well-being of 48 adolescents with either cystic fibrosis (CF) or insulin-dependent diabetes mellitus (IDDM) was measured by four standardized questionnaires. The adolescents' perception of severity of illness was measured using an original instrument (PSCI), and this measure was compared to their physicians' estimates of how the adolescents perceived the severity of their illness and clinical illness.
There were 24 patients in both the CF and IDDM groups. Both groups were found to function well psychosocially; although, there were more patients with low self image compared to normative values. Depression and low self image were associated with a greater adolescent perception of illness severity. For both chronic illness groups, physicians' assessment of assumed adolescent perception of disease severity correlated with clinical indices of disease severity and was higher than the perception of illness severity reported by the adolescents. For adolescents with CF, but not with IDDM, perception of severity of chronic illness correlated with clinical indices.
For adolescents with chronic illness, their perception of illness severity is an important indicator of psychosocial well-being. Physicians do not accurately infer their patients' perception of illness severity. 相似文献
Methods:
The psychological well-being of 48 adolescents with either cystic fibrosis (CF) or insulin-dependent diabetes mellitus (IDDM) was measured by four standardized questionnaires. The adolescents' perception of severity of illness was measured using an original instrument (PSCI), and this measure was compared to their physicians' estimates of how the adolescents perceived the severity of their illness and clinical illness.
Results:
There were 24 patients in both the CF and IDDM groups. Both groups were found to function well psychosocially; although, there were more patients with low self image compared to normative values. Depression and low self image were associated with a greater adolescent perception of illness severity. For both chronic illness groups, physicians' assessment of assumed adolescent perception of disease severity correlated with clinical indices of disease severity and was higher than the perception of illness severity reported by the adolescents. For adolescents with CF, but not with IDDM, perception of severity of chronic illness correlated with clinical indices.
Conclusions:
For adolescents with chronic illness, their perception of illness severity is an important indicator of psychosocial well-being. Physicians do not accurately infer their patients' perception of illness severity. 相似文献
890.
Tyson J; Tranebjaerg L; Bellman S; Wren C; Taylor JF; Bathen J; Aslaksen B; Sorland SJ; Lund O; Malcolm S; Pembrey M; Bhattacharya S; Bitner-Glindzicz M 《Human molecular genetics》1997,6(12):2179-2185
The Jervell and Lange-Nielsen syndrome (JLNS) comprises profound congenital
sensorineural deafness associated with syncopal episodes. These are caused
by ventricular arrhythmias secondary to abnormal repolarisation, manifested
by a prolonged QT interval on the electrocardiogram. Recently, in families
with JLNS, Neyroud et al. reported homozygosity for a single mutation in
KVLQT1 , a gene which has previously been shown to be mutated in families
with dominantly inherited isolated long QT syndrome [Neyroud et al . (1997)
Nature Genet ., 15, 186-189]. We have analysed a group of families with
JLNS and shown that the majority are consistent with mutation at this
locus: five families of differing ethnic backgrounds were homozygous by
descent for markers close to the KVLQT1 gene and a further three families
from the same geographical region were shown to be homozygous for a common
haplotype and to have the same homozygous mutation of the KVLQT1 gene.
However, analysis of a single small consanguineous family excluded linkage
to the KVLQT1 gene, establishing genetic heterogeneity in JLNS. The
affected children in this family were homozygous by descent for markers on
chromosome 21, in a region containing the gene IsK . This codes for a
transmembrane protein known to associate with KVLQT1 to form the slow
component of the delayed rectifier potassium channel. Sequencing of the
affected boys showed a homozygous mutation, demonstrating that mutation in
the IsK gene may be a rare cause of JLNS and that an indistinguishable
phenotype can arise from mutations in either of the two interacting
molecules.
相似文献