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61.
5—羟色胺M受体和胆碱能受体阻断剂在红霉素所致小肠动力紊乱和呕吐中的作用 总被引:1,自引:0,他引:1
秦新裕 《复旦学报(医学版)》1995,(1)
本实验对8条犬进行小肠肌电测定,并在记录期间分别静注胆碱能神经阻断剂,阿托品和六甲季胺,以及5-羟色胺(5-HT)M受体阻断剂,灭吐灵,以观察其对红霉素所致肠道副作用的影响。结果发现阿托品和六甲季胺不仅能明显地抑制空腹时正常传播性肌电综合波(MMC)的发生和传播,降低红霉素促进小肠动力的作用,还能减轻红霉素所致饱腹动物的快波数增加,但对呕吐无明显影响。灭吐灵的实验结果显示红霉素的致吐作用是由5-HTM受体介导的,与其促进小肠动力的作用无明显因果关系。 相似文献
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Hakko H Lintunen J Lappalainen J Mäkikyrö T Räsänen P Timonen M;STUDY- Workgroup 《Addictive behaviors》2006,31(10):1873-1880
The purpose of this research was to evaluate the level of nicotine dependence (ND) and to examine its association to psychiatric disorders in a representative clinical sample of adolescent psychiatric inpatients. The modified Fagerstrom Tolerance Questionnaire (mFTQ) was used to assess the level of ND. Psychiatric DSM-IV diagnoses were obtained by using the Schedule for affective disorder and schizophrenia for school-age children (K-SADS-PL). Of the total of 342 inpatients in the study sample, 259 (75.7%) reported to be current smokers. A sum score 6 or higher in the mFTQ, indicating a high level of ND, was found in 37.9% of all smokers. An increased likelihood for high level of ND was associated with substance related disorders (OR 5.1, 95% CI 2.8-9.3), conduct disorder and oppositional defiant disorders (OR 2.4, 95% CI 1.4-4.4). The usefulness of mFTQ in measuring ND among adolescent inpatients is apparent. Therefore, it can be recommended to be used as a routine screening instrument for ND among adolescents hospitalized due to psychiatric disorders. 相似文献
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Callaway J Storvik M Halonen P Hakko H Räsänen P Tiihonen J 《Human psychopharmacology》2005,20(7):467-472
Monthly binding densities (B(max)) of [3H]citalopram to the platelet serotonin transporter (SERT) was measured longitudinally over 1 year in a control group of 18 healthy Finnish male volunteers. Single platelet samples were also analysed from 33 men who were incarcerated for violent crimes during the same calendar year. A statistically significant seasonal variation in SERT B(max) was observed in both data sets, and bi-monthly floating averages for SERT B(max) were calculated and then fit to an annual sinusoidal curve for both groups. The B(max) for platelet [3H]citalopram binding showed a statistically significant (p = 0.001) seasonal variance between a winter (January-February) maximum of 1590 fmol/mg protein and a summer (July-August) minimum of 1216 fmol/mg protein for the control group, with an R2 of 70% for the annual sinusoidal curve fit. A statistically significant (p = 0.007) seasonal variance was also observed between a winter (January-February) maximum of 1980 fmol/mg protein and an autumnal (August-September) minimum of 1234 fmol/mg protein for the violent offenders, again with an R2 of 70% for the annual sinusoidal curve fit. This observation lends additional support to the idea that violent human behavior and impulsivity may be directly linked to values of SERT B(max), which can be affected by various psychoactive drugs and also varies with the natural change of seasons. 相似文献
68.
Mustanoja S Luukkonen AH Hakko H Räsänen P Säävälä H Riala K;STUDY- workgroup 《Child psychiatry and human development》2011,42(4):495-506
We examined the relationship of exposure to domestic violence and violence occurring outside home to bullying behaviour in
a sample (508; 40.9% males, 59.1% females) of underage psychiatric inpatient adolescents. Participants were interviewed using
K-SADS-PL to assess DSM-IV psychiatric diagnoses and to gather information about domestic and other violence and bullying
behaviour. Witnessing interparental violence increased the risk of being a victim of bullying up to 2.5-fold among boys. For
girls, being a victim of a violent crime was an over 10-fold risk factor for being a bully–victim. Gender differences were
seen in witnessing of a violent crime; girls were more likely to be bullies than boys. Further, as regards being a victim
of a violent crime outside home and physical abuse by parents at home, girls were significantly more often bully–victims than
boys. When interfering and preventing bullying behaviour, it is important to screen adolescents’ earlier experiences of violence. 相似文献
69.
Matti Laukkanen MScHealth Helin? Hakko PhD Kaisa Riala PhD Pirkko R?s?nen MD PhD STUDY- Workgroup 《Journal of addictive diseases》2013,32(4):69-79
ABSTRACT This study investigated whether adolescent's family type was associated with regular smoking or the use of illicit substances (cannabis or hard drugs) among underage adolescent psychiatric in-patients. The sample consisted of 471 adolescents aged 12–17 years admitted to psychiatric hospital between April 2001 and March 2006 at Oulu University Hospital, Finland. The information on family factors and substance use was based on the Schedule for Affective Disorder and Schizophrenia for School-Age Children, Present and Lifetime interview and the European modification of the Addiction Severity Index questionnaire. Compared to adolescent boys from two-parent families, those from child welfare placement were more likely to regularly use both cannabis (odds ratio [OR] = 4.4; 95% confidence interval [CI] = 1.4–13.7; P = .012) and hard drugs (OR = 8.4; 95% CI = 1.7–42.1; P = .01). Among girls, no association was found between family type and the use of illicit substances. Two-parent or foster family units may protect adolescents from involvement with illicit substances. In clinical adolescent psychiatric practice more attention should be paid to family interventions and parental support. 相似文献
70.
HH Chen MR Phillips H Cheng QQ Chen XD Chen D Fralick YE Zhang M Liu J Huang M Bueber 《上海精神医学》2012,24(6):305-321
The following document is a translation of the first national mental health law of the People''s Republic of China, which was adopted by the National People''s Congress on October 26, 2012. The original Chinese version of the law is available at the official government website: http://www.gov.cn/jrzg/2012-10/26/content_2252122.htm. The translation was completed by a team of translators at the Shanghai Mental Health Center at the Shanghai Jiao Tong University School of Medicine. The translators have added footnotes at the end of the document that explain their choices in sections where alternative translations are possible and that provide background information for sections that may be confusing to readers unfamiliar with China. This translation should be cited as follows:ChenHH, Phillips MR, Cheng H, Chen QQ, Chen XD, Fralick D, Zhang YE, Liu M, Huang J, Bueber M. Mental Health Law of the People''s Republic of China (English translation with annotations). Shanghai Archives of Psychiatry. 2012; 24(6):305-321. doi:10.3969/j.issn.1002-0829.2012.06.001Shanghai Archives of Psychiatry 相似文献