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411.
Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis 总被引:6,自引:2,他引:6
Ronday HK; Smits HH; Quax PH; van der Pluijm G; Lowik CW; Breedveld FC; Verheijen JH 《Rheumatology (Oxford, England)》1997,36(1):9-15
The observed increase in urokinase-type plasminogen activator (u-PA) and
its receptor (u-PAR) in synovial tissue of patients with rheumatoid
arthritis (RA) suggests pathophysiological involvement of the plasminogen
activation (PA) system in inflammatory joint disease. In the present study,
we investigated the capacity of the PA system to degrade non-mineralized
and mineralized bone-like matrix in vitro as a model for bone destruction.
Transfected mouse LB6 cell lines, that expressed either human u-PA or
u-PAR, were cultured separately and simultaneously on radiolabelled bone
matrix in the presence of plasminogen. Osteoblast-like murine calvarial
MC3T3-E1 cells were used to produce a well-characterized, highly organized
bone-like matrix, that could be mineralized in the presence of
beta-glycerol phosphate. Bone matrix degradation was followed by the
release of radioactivity in the culture medium. u-PA-producing cells, in
contrast to u-PAR- producing cells, degraded both non-mineralized and
mineralized bone matrix. This effect could be inhibited by anti-u-PA
antibodies, as well as by tranexamic acid and by aprotinin, indicating that
the degrading activity is u-PA mediated and plasmin dependent.
Co-cultivation of a small portion of u-PA-producing cells with
u-PAR-expressing cells resulted in a marked increase in degradation
activity. Reduction of this potentiating effect by suramin or the
amino-terminal fragment of u- PA, both competitive inhibitors of u-PA
receptor binding, shows that this synergistic effect is due to binding of
u-PA to u-PAR. u-PAR must be cell associated, as binding of u-PA to a
soluble u-PAR prevented this enhancement. The capability of the PA system
to degrade bone matrix in vitro, and the previously demonstrated increased
expression of u-PA and u-PAR in synovial tissue of patients with RA,
further support a role for the PA system in the development of bone
erosions.
相似文献
412.
目的:测定青少年田径运动员的人格因素特征,为田径运动员的选材、培养和使用提供必要的心理依据。方法:于2005-10/11从中国矿业大学、徐州师范大学、徐州市第三中学、徐州云龙山体校4所学校的田径运动员中随机抽取116名为调查对象。同时随机抽取同一年龄段的134名普通学生作为对照。采用卡氏十六种人格因素表、双重个性因素的推导公式、十六种人格因素测验应用公式进行调查。其中卡氏十六种人格因素表标准分为1~10分,<4.5分为低分,4.5~6.5分为中间分,>6.5分为高分。得分越高,其特征为乐群外向、聪慧、富有才识、情绪稳定、好强固执、轻松兴奋、有恒负责、冒险敢为、敏感、感情用事、怀疑刚愎、幻想、狂放不羁、精明能干、世故、忧虑抑郁、烦恼多端、自由、批评激进、自主、当机立断、知己知彼、自律谨严、紧张困扰。结果:发放问卷250份,回收有效问卷219份。其中田径运动员108名,男55名,女53名。普通高中生111名,男55名,女56名。①男田径运动员乐群性、有恒性、忧虑性、自律性、紧张性5项因素得分高于普通男生,差异有显著性(6.891±1.802,5.418±1.536;6.455±1.951,4.980±1.484;6.000±1.633,5.382±1.604;6.964±1.598,5.691±1.998;5.818±1.657,5.036±1.677,P<0.05~0.01)。②男田径运动员在怯懦与果断型一项因素得分低于普通男生,差异显著(5.004±1.418,5.880±1.327,P<0.01)。③男田径运动员在专业有成就者的个性因素、在新环境中有成长能力个性因素得分高于普通男生(61.100±6.705,54.945±9.296;24.001±3.093,21.273±4.030),男田径运动员在创造能力个性因素得分低于普通男生(4.709±1.729,5.655±1.828),差异均有显著性(P<0.01)。④女田径运动员与普通女生有恒性、敏感性、幻想性、实验性、自律性5项因素评分比较,差异显著(6.453±1.475,4.554±1.726;5.736±1.595,6.357±1.645;5.434±1.896,6.554±1.525;4.792±1.524,5.911±1.478;6.924±1.639,5.289±1.692,P<0.05~0.01)。⑤女田径运动员在怯懦与果断型一项得分低于普通女生,差异有显著性(4.630±1.547,6.254±1.682,P<0.05~0.001)。⑥女田径运动员在专业有成就者的个性因素、在新环境中有成长能力个性因素得分高于普通女生(57.906±8.349,52.464±9.332;23.793±3.953,20.250±4.010),女田径运动员在创造能力个性因素得分低于普通女生(5.094±1.656,5.875±1.849),差异均有显著性(P<0.05~0.01)。结论:男、女田径运动员在有恒性、自律性、专业有成就者的个性因素、在新环境中有成长能力个性因素上存在相似优点,男性外向、热情、乐群,与他人相处时合作与适应新环境能力较强,女性除这些良好特征外,表现更显持稳、保守、传统、务实、理智、重现实。男、女田径运动员同时也存在轻度紧张、烦恼不安,都对教练员依赖性大、顺从性高,缺乏创新精神。 相似文献
413.
目的:了解贫困地区小学生睡眠状况,探讨提高农村儿童睡眠质量的有效措施。方法:于2005-10在吉林省的国家级贫困县应用澳大利亚悉尼大学儿童睡眠中心临床问卷的中国修订版(内容涉及儿童个人情况、睡眠状况、家庭居住环境,父母睡眠状况、吸烟状况,以及父母职业及受教育程度、家庭成员之间的关系等),采用二阶段整群随机抽样法,对750名小学生的睡眠状况进行调查分析,统计分析近1年内儿童在未患重大疾病时的睡眠状况,包括全天睡眠时间分布状况、睡眠障碍发病率及其相关影响因素,根据美国精神障碍诊断统计手册中儿童睡眠障碍的诊断标准,将每周出现1~3次单一或几种睡眠障碍相关症状,定为存在睡眠问题。结果:共发放问卷750份,回收有效问卷691份,回收率为92.1%。6岁和13岁组人数较少予以去除,实际纳入分析者669名。其中男生300名,女生369名;汉族361名,朝鲜族288名,其他民族20名;7岁组96名,8岁组93名,9岁组94名,10岁组122名,11岁组128名,12岁组136名。①贫困县小学生全天睡眠时间均值为(9.62±1.12)h,汉族小学生全天平均睡眠时间比朝鲜族学生长[(9.75±1.23),(9.48±0.90)h,P<0.01]。各年龄组学生全天睡眠时间差异无统计学意义(F=0.169,P>0.05)。②睡眠障碍总时点发病率为27.40%。低年级组小学生(一~四年级)睡眠障碍发病率高于高年级组(五~六年级)(31.80%,24.15%,P<0.05),男生睡眠障碍发病率高于女生(35.35%,20.95%,P<0.01)。③睡眠障碍症状发病率前5位依次为:睡眠不安(8.4%),睡眠姿势异常(8.3%)、张口呼吸(6.1%),梦呓(5.2%);打鼾(4.3%)。④调查结果经单因素相关分析及多重逐步回归分析显示抚养人睡眠习惯、儿童睡眠姿势异常、母亲管教孩子态度和父亲学历等是影响睡眠时间的主要因素。⑤Logistic回归分析显示,孩子患呼吸系统疾病、父母教育孩子方法、母亲有无睡眠障碍、父母之间关系、儿童体弱多病等是睡眠障碍的主要危险因素。结论:贫困地区儿童睡眠障碍是多因素共同作用的结果;孩子的抚养人应改掉不良的睡眠习惯,为儿童提供良好的生活、睡眠环境;增强儿童身体素质,积极防治呼吸系统疾病,应作为近期降低贫困县小学生睡眠障碍的有效措施。 相似文献
414.
Lahti A Räsänen P Karvonen K Särkioja T Meyer-Rochow VB Hakko H 《Neuropsychobiology》2006,54(2):140-146
Suicide is one of the leading causes of death among adolescents worldwide. Studies on the seasonal pattern of youth suicides are rare and the results are very contradictory and heterogeneous. Generally, suicide methods affect the pattern of suicide seasonality. Shooting is the most common suicide method among Finnish adolescents. We investigated whether shooting suicides of victims aged less than 18 years are correlated with a specific period of the year. Also, the seasonal pattern of shooting suicides in adolescents was compared with that of adult victims. Our data comprised 42 adolescent suicide victims and, for comparison, 1,926 adult suicide victims over the years 1988 to 2004 from Northern Finland. Of these, 59.5% (n = 25) of the adolescents and 28.8% (n = 554) of the adults had committed suicide by shooting.We observed that shooting suicides among the under-aged showed a significant peak in autumn (ratio 2.70, 95% CI: 1.97-3.42), while those of adult victims peaked in spring (ratio 1.19, 95% CI: 1.05-1.35). The monthly pattern of suicides correlated significantly with the mean duration of daily sunshine hours (trailing by 3 months) in the under-aged (r = 0.67, p = 0.016), but not in the adults (r = 0.06, p = 0.854). The role of firearm availability, psychosocial factors such as start of the school year, and some biological factors are discussed. 相似文献
415.
J Weisser-Thomas VA Ferrari A Lakghomi LM Lickfett G Nickenig HH Schild D Thomas 《The British journal of radiology》2014,87(1038)
Objective
Cardiac MR (CMR) identifies the substrate of ventricular arrhythmia (VA) in cardiomyopathies and coronary heart disease. However, little is known about the value of CMR in patients with VA without previously known cardiac disorders.Methods
76 patients with VA (Lown ≥2) without known cardiac disease after regular diagnostic work-up were studied with CMR, and findings were correlated with electrocardiogram (ECG) and electrophysiological stimulation (EPS). Structural abnormalities matching the VA origin as defined by ECG and/or EPS, or a CMR-detected cardiac condition known to cause arrhythmia were defined as VA substrate. CMR findings were defined as clinically relevant, if resulting in a new diagnosis, change of treatment or additional diagnostic procedure.Results
44/76 patients demonstrated pathological CMR findings. In 24/76 patients, the pathology was detected by CMR and not by echocardiography. CMR-based diagnoses of cardiac disease were established in 20/76 patients, and all were morphological substrates for VA. In seven patients, the location of the CMR finding (scar) directly matched the VA origin. CMR findings resulted in a change of treatment in 21 patients and/or additional diagnostics in 8 patients.Conclusion
Undetected cardiac conditions are frequent causes of VA. This is the first study demonstrating the value of CMR for detection of morphological substrate and/or underlying cardiac disorders in VA patients without known cardiac disease.Advances in knowledge
The high incidence of clinically relevant CMR findings which were not detected during initial diagnostic work-up strongly supports the use of CMR to screen VA patients for underlying heart disease.Although the value of cardiac MR (CMR) for the diagnosis of cardiac diseases such as myocarditis is undisputed, CMR is also predictive of patients at high risk for ventricular arrhythmias (VAs) with conditions such as hypertrophic cardiomyopathy (HCM) and coronary heart disease (CHD).1–3 Recent studies have demonstrated the ability of CMR to identify the anatomical correlate of VA in those patients. This anatomical correlate has been characterized by CMR as a structural abnormality (e.g. fibrosis or peri-infarct region), which may go undetected using other non-invasive imaging modalities.4,5 A number of studies have been undertaken, or are ongoing, to further elucidate the added value of CMR in patients with known cardiac conditions, to improve risk stratification for VA and to optimize therapy.1,6–8 However, little is known to date regarding the added value of CMR for detection of an arrhythmogenic substrate or underlying cardiac condition in patients who present with VAs without known cardiac disease.Thus, the purpose of this study was to investigate the added value of CMR in patients with VAs for detection of underlying heart disease and an arrhythmogenic morphological substrate, and also to investigate the clinical relevance of CMR in those patients with positive findings. 相似文献416.