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The radioallergosorbent (RAST) technique was used as a diagnostic test for onchocerciasis. IgE antibodies for Dirofilaria immitis antigen were found in thirty-one of fifty-seven (54%) affected patients. 相似文献
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Atrial Fibrillation and Embolic Complications in Paced Patients 总被引:5,自引:0,他引:5
HEINER LANGENFELD WOLFRAM GRIMM BERNHARD MAISCH KURT KOCHSIEK 《Pacing and clinical electrophysiology : PACE》1988,11(11):1667-1672
Atrial fibrillation (AF) and thromboembolism are discussed to he complications of the WI mode. We reinvestigated the spontaneous ECG and the anamnesis of 246 pacemaker patients with the indications second and third degree atrioventricular block (AV block, n = III), sick sinus syndrome (SSS, n - 101) and other indications (n = 34), all had shown sinus rhythm at implantation. The mean implantation time was 63 ± 45 months (203 VVI and 43 dual chamber pacemkers). The results: (1) Atrial fibrillation was found in 63 patients (26%). Only one of them had a DDD pacemaker inserted, the implantation time of dual chamber devices being shorter, however, (2) The incidence of AF in patients with SSS (37%) was significantly higher (P < 0.01) than in patients with AV block (19%). (3) Three patients suffered from strokes or transitory ischemic attacks in the follow-up, only one of them had AF at control. Conclusions: Our results confirm that VVI stimulation favors AF long-term which is most likely due to irritation of the atrial rhythm by retrograde conduction. In our patients the incidence of thromboembolic complications was not higher in the group of patients with AF. However, from this study in surviving patients, we cannot exclude that we Jost some patients due to severe stroke. 相似文献
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Hypersensitivity to chemicals. Correlation of tartrazine hypersensitivity with characteristic serum IgD and IgE immune response patterns 总被引:1,自引:0,他引:1
A radioimmunoassay inhibition test (CARIAT) has been developed to measure human anti-tartrazine IgD and IgE antibodies. Graphical analysis of the data obtained has shown that patients with clinically identified tartrazine hypersensitivity can be distinguished from controls by singular characteristics of their IgD but not their IgE antibody patterns. Clinical diagnoses of tartrazine hypersensitivity correlate with relative levels of serum IgD antibody specific for a soluble conjugate of tartrazine with rabbit serum albumin (TZ-RSA). These tartrazine sensitive patients, however, have lower levels of ‘nonspecific’ IgD than controls, i.e., IgD that reacts with cellulose discs conjugated to phenylsulphonic acid antigenic determinants but does not react with TZ-RSA. Although it is significant that the observations demonstrate an association of raised specific IgD levels in patients relative to controls, the possible presence in controls of IgD antibodies against other tartrazine antigenic determinants which may play a role in ameliorating or preventing allergic responses should be considered. Anti-tartrazine IgD or IgE antibody was determined by assay of the IgD or IgE binding to paper discs coupled to a tartrazine antigen analog (AP-discs). Each result was compared with the amount of antibody binding if the patient's or control serum was preincubated with a free soluble tartrazine-protein conjugated antigen, before being tested on the discs coupled with antigen (AP-discs). Reduction of the amount of IgD or IgE binding to the disc-coupled antigen, when the sera were preincubated with free soluble antigen, indicated specificity of the antibodies for tartrazine antigenic determinants. The specificity of the serum anti-tartrazine antibodies assayed appears to be the phenylsulphonic moiety, suggesting that the sensitizing agent responsible need not have been tartrazine but could have been one or more of the many other synthetic environmental chemicals with a sulphonated benzene ring. The results obtained suggest that diagnostic tests may be developed for tartrazine hypersensitivity and for hypersensitivity to other chemicals. 相似文献
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IgG4 in Human Colostrum and Human Milk: Continued Local Production or Selective Transport from Serum
MARGARET A. KELLER LILIANE GENDREAU-REID DOUGLAS C. HEINER ANNETTE RODRIGUEZ JEFFREY A. SHORT 《Acta paediatrica (Oslo, Norway : 1992)》1988,77(1):24-29
ABSTRACT. Colostrum, mature milk, and paired plasma samples were obtained from 10 postpartum women who had not been previously studied. The geometric mean concentration of IgG4 in colostrum (3.3 μg/ml) was similar to the mean concentration in mature milk (3.0 μg/ml). The arithmetic mean for the percent of IgG = IgG4 was 10.3±3.3% for colostrum, 10.3±3.1% for mature milk, 2.6±0.3% for early plasma, and 1.7±0.3% for later plasma. Local mammary production of immunoglobulin was determined by subtracting the estimated serum contribution from the measured concentration in colostrum or milk. Evidence for local mammary production of IgG4 was found in 5 of 10 colostrum samples and 8 of 10 mature milk samples. These observations indicate that the previously observed selective enrichment of IgG4 in colostrum is also true for mature milk. These are the first studies suggesting continued local production of any immunoglobulin other than IgA in mature human breast milk. 相似文献
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Physiological stimulation can be achieved by either bifocal or rate responsive pacing. The latter pacemakers adapt the heart rate to physical activity by biological signals. Out of many possible approaches only three pacemaker systems for rate responsive pacing are available: the QT-pacemaker (Tx or Quintech), the respiratory biorate pacemaker, and the activity detecting Activitrax. Our own experiences (8 QT, 6 Biorate, 8 Activitrax pacemakers) and a survey of 95 QT- and 37 Biorate pacemakers from 11 centers are reported. The Biorate pacemaker functions without any problems; its present disadvantage is limited programmability. With the Tx pacemaker failing, frequency adaptation (26%) was found more often in the early series, mostly due to voltage polarization at the tip of the electrode. The Activitrax pacemaker gives satisfactory frequency adaptation, largely depending on the activity of the muscles of the shoulder and pectoral region. 相似文献
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HEINER LANGENFELD CHRISTIANE KÖHLER JÖRG WEIRICH MICHAEL KIRSTEIN KURT KOCHSIEK 《Pacing and clinical electrophysiology : PACE》1992,15(11):2097-2102
The prolongation of the action potential duration (APD) induced by sotalol has been shown to be diminished with increasing heart rate. This phenomenon is called "reverse use dependence." We examined the la, Ib, and Ic effects of different Class I drugs on the APD under normal and fast stimulation rates (1.0 and 2.5 Hz) in isolated rabbit atria) and ventricular muscles by means of intracelular microelectrodes. Results (n = 98): With 1.0 Hz lidocaine fib, 4.3 ċ 10−5 M) shortened the APD at 90% repolarization (APD90) in the atrium by 9% and in the ventricle lay 8% (NS), whereas quinidine (la, 2.2 ċ 10 −5 M) and prajmaline (la, 10 −6 M) prolonged the APD90 in the atrium (quinidine +45%; prajmaline +10%, P < 0.001) and in the ventricle (+ 42%, P < 0.001; +17%, P < 0.05J. Propafenone (Ic, 2.6 ċ 10 −6 M) showed this effect only in the atrium (APD90 + 33%; P < 0.01). With the faster stimulation rate of 2.5 Hz we could not find a significant influence of any drug on the APD90 in the ventricle and only quinidine prolonged the APD90 in the atrium by 16% (P < 0.05). Conclusions: The subclassification of Class I antiarrhythmic drugs that is based on APD modifying influences is only valid under normal heart rates (1.0 Hz). During tachycardia these actions are absent and the phenomenon of "reverse use dependence" is found in Class I drugs. Therefore, an additional antiarrhythmic effect due to APD modification by the examined drugs should not be expected at rapid heart rates. 相似文献
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Flow-cytometric analysis of human basophil degranulation 总被引:2,自引:0,他引:2
T. NAKAGAWA B. M. STADLER D. C. HEINER F. SKVARIL A. L. DE WECK 《Clinical and experimental allergy》1981,11(1):21-30
Quantification of human basophil degranulation induced by anti-IgE, anti-IgG4, and by ionophore was performed using a flow-cytometric system. It was shown that these antibodies and ionophore can degranulate basophils in a dose-dependent manner, and that there is a wide variation in the response of basophils obtained from different individuals to these stimuli. A significant correlation was observed between the degree of degranulation induced by anti-IgE and anti-IgG4, while this was not the case for anti-IgE and ionophore. It was also shown that IgG4 myeloma protein can passively sensitize basophils. In general, degranulating efficacy was in the order of ionophore > anti-IgE >anti-IgG4, both in allergic and non-allergic individuals. 相似文献
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HEINER RENNEBERG GUNTHER WENNEMUTH LUTZ KONRAD GERHARD AUMÜLLER 《Journal of anatomy》1997,190(3):343-349
An antiserum against secretory vesicles from human seminal fluid (prostasomes) was used to study the localisation and distribution of the respective antigen(s) during prenatal development and pubertal maturation of the human prostate. The crude antiserum stained both secretory and membrane proteins in the adult prostate and other glands, such as pancreas and parotid gland. An immunoaffinity purified fraction from the antiserum selectively reacted with the apical plasma membrane of prostatic epithelium adluminal cells, recognizing a 100 kDa antigen (PMS). Even in the earliest stages of embryonic prostate specimens studied, the adluminal plasma membrane of the epithelial cells from developing glandular anlagen reacted strongly. The occurrence of PMS immunoreactivity in prostatic anlagen was directly correlated with lumen formation. As the antigen is an androgen-independently synthesised membrane protein of the prostate, it may possibly be used as a marker of cell polarity in the normal and pathologically altered prostate. 相似文献