全文获取类型
收费全文 | 1496562篇 |
免费 | 127100篇 |
国内免费 | 5264篇 |
专业分类
耳鼻咽喉 | 24620篇 |
儿科学 | 45645篇 |
妇产科学 | 41278篇 |
基础医学 | 193564篇 |
口腔科学 | 41939篇 |
临床医学 | 139020篇 |
内科学 | 311326篇 |
皮肤病学 | 37685篇 |
神经病学 | 121567篇 |
特种医学 | 60371篇 |
外国民族医学 | 435篇 |
外科学 | 250738篇 |
综合类 | 31358篇 |
现状与发展 | 77篇 |
一般理论 | 436篇 |
预防医学 | 99076篇 |
眼科学 | 34793篇 |
药学 | 102807篇 |
2篇 | |
中国医学 | 3103篇 |
肿瘤学 | 89086篇 |
出版年
2018年 | 19072篇 |
2017年 | 16803篇 |
2016年 | 18789篇 |
2015年 | 20161篇 |
2014年 | 31750篇 |
2013年 | 40413篇 |
2012年 | 39396篇 |
2011年 | 41354篇 |
2010年 | 31084篇 |
2009年 | 33932篇 |
2008年 | 40155篇 |
2007年 | 41736篇 |
2006年 | 44584篇 |
2005年 | 40902篇 |
2004年 | 39338篇 |
2003年 | 37293篇 |
2002年 | 36937篇 |
2001年 | 67920篇 |
2000年 | 68909篇 |
1999年 | 59102篇 |
1998年 | 18407篇 |
1997年 | 16953篇 |
1996年 | 16235篇 |
1995年 | 15364篇 |
1994年 | 13440篇 |
1993年 | 12231篇 |
1992年 | 44474篇 |
1991年 | 43029篇 |
1990年 | 41916篇 |
1989年 | 41059篇 |
1988年 | 38266篇 |
1987年 | 37566篇 |
1986年 | 36095篇 |
1985年 | 34105篇 |
1984年 | 25564篇 |
1983年 | 21723篇 |
1982年 | 13162篇 |
1979年 | 24308篇 |
1978年 | 17479篇 |
1977年 | 15239篇 |
1976年 | 13635篇 |
1975年 | 15595篇 |
1974年 | 18363篇 |
1973年 | 17860篇 |
1972年 | 17139篇 |
1971年 | 15980篇 |
1970年 | 15174篇 |
1969年 | 14501篇 |
1968年 | 13544篇 |
1967年 | 12064篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Effectiveness and nutritional consequences of amino acid-based vs glucose-based dialysis solutions in infants and children receiving CAPD 总被引:2,自引:0,他引:2
Excessive glucose absorption and dialysate amino acid and protein losses contribute to malnutrition in children on glucose-based continuous ambulatory peritoneal dialysis (CAPD). We used 2.5 and 4.25% glucose and 1.1 and 2.0% amino acid dialysates to assess short-term effectiveness and nutritional consequences of amino acid-based dialysis solutions. Plasma and effluent urea and creatinine concentrations were similar with amino acid and glucose dialysis although 16% less fluid was removed with amino acid dialysates. Absorption of 77.3 +/- 5.3% of dialysate amino acids exceeded losses of amino acids and protein in glucose effluent. With amino acid dialysates, fasting plasma glucose concentrations were maintained while plasma amino acid levels rose, peaked at 1 h, and, excepting methionine, isoleucine, and phenylalanine with the 2.0% solution, returned to initial levels after 5 h. Compared with glucose, amino acid dialysates provide reduced but satisfactory fluid and waste removal, maintain normoglycemia, and more than compensate for effluent losses of amino acids and protein. 相似文献
993.
994.
995.
Fulminant hepatic failure associated with aplastic anaemia after treatment with danazol. Case report
T. NAKAJIMA Consultant N. MIZUSHIMA Registrar H. MATSUDA Registrar M. MATSUMOTO Registrar K. TAMAKOSHI Senior Registrar H. ISHII Consultant S. MORIOKA Consultant K. KANAI Associate Professor Y. IKEDA Senior Lecturer T. TERAO Associate Professor 《BJOG : an international journal of obstetrics and gynaecology》1986,93(9):1013-1015
996.
Elevated levels of free putrescine and N1-acetylspermidine in cyst fluids of malignant brain tumours. 下载免费PDF全文
H Yamazaki T Tsukahara J Uki S Matsuzaki 《Journal of neurology, neurosurgery, and psychiatry》1986,49(2):209-210
The contents of free and conjugated polyamines in cyst fluids of brain tumours were analysed. The putrescine and N1-acetylspermidine levels in cyst fluids of malignant brain tumours were significantly higher than those of benign tumours. The free spermidine levels in malignant and benign tumours were about the same, while the total spermidine levels were higher in malignant than those in benign tumours. These results suggest that polyamine levels in cyst fluids reflect the altered polyamine metabolism in brain tumours. 相似文献
997.
Sarcoplasmic reticulum calcium load regulates rat arterial smooth muscle calcium sparks and transient KCa currents 总被引:1,自引:1,他引:0
Voltage-gated Na+ current is reduced by acid solution. Protons reduce peak Na+ conductance by lowering single channel conductance and shift the voltage range of gating by neutralizing surface charges. Structure-function studies identify six carboxyls and a lysine in the channel's outer vestibule. We examined the roles of the superficial ring of carboxyls in acid block of Nav 1.4 (the rat skeletal muscle Na+ channel isoform) by measuring the effects of their neutralization or their substitution by lysine on sensitivity to acid solutions, using the two-micropipette voltage clamp in Xenopus oocytes. Alteration of the outer ring of carboxylates had little effect on the voltage for half-activation of Na+ current, as if they are distant from the channels' voltage sensors. The mutations did not abolish proton block; rather, they all shifted the p K a (-log of the dissociation constant) in the acid direction. Effects of neutralization on p K a were not identical for different mutations, with E758Q > D1241A > D1532N > E403Q. E758K showed double the effect of E758Q, and the other lysine mutations all produced larger effects than the neutralizing mutations. Calculation of the electrostatic potential produced by these carboxylates using a pore model showed that the p K a values of carboxylates of Glu-403, Glu-758, and Asp-1532 are shifted to values similar to the experimentally measured p K a . Calculations also predict the experimentally observed changes in p K a that result from mutational neutralization or introduction of a positive charge. We propose that proton block results from partial protonation of these outer ring carboxylates and that all of the carboxylates contribute to a composite Na+ site. 相似文献
998.
999.
Angiogenesis induction and regression in human surgical wounds 总被引:2,自引:0,他引:2
Nicola J. Brown PhD ; Edward A. E. Smyth Bmedsci ; Simon S. Cross MD ; Malcolm W. R. Reed MD 《Wound repair and regeneration》2002,10(4):245-251
Angiogenesis in human wound healing is not well characterized, with only sparse information available regarding the maturation and fate of vessels formed as a consequence of human tissue repair. Therefore, this study aimed to establish the temporal profile of angiogenesis in human dermal wounds. Punch biopsies were obtained under local anesthesia from 45 patients following breast surgery. Scars were predominantly between 2 and 52 weeks after surgery but in five patients were > 52 weeks. Control samples were taken from breast skin peroperatively (n = 24). Quantification of vascular density was performed using the Chalkley grid, following antibody staining for platelet endothelial cell adhesion molecule. Vascular patterns, wound cellularity and morphology were also determined. Cumulative microvessel density was increased in all samples when compared to controls (p < 0.05). This was greatest 2 to 24 weeks following surgery 17 (15-21) median (range), decreased thereafter, but remained elevated compared to controls even in the mature scars > 52 weeks. Control tissue showed an ordered morphological arrangement of dermal structures, collagen, and elastic fibers. However, wounding resulted in marked structural distortion for up to 15 weeks. In conclusion, this study shows for the first time the prolonged persistence of both microvessels and cellularity (fibroblastic cells), in addition to structural distortion in human dermal wounds, which is in contrast to previous in vitro and in vivo studies. 相似文献
1000.
Physiologic mechanism and preoperative prediction of new-onset dysphagia after laparoscopic Nissen fundoplication 总被引:2,自引:0,他引:2
Dennis Blom M.D. Jeffrey H. Peters M.D. Tom R. DeMeester M.D. Peter F. Crookes M.D. Jeffrey A. Hagan M.D. Steven R. DeMeester M.D. Cedric Bremner M.D. 《Journal of gastrointestinal surgery》2002,6(1):22-28
The aim of this study was to determine whether preoperative physiologic factors can account for and be used to predict the
development of postoperative dysphagia after laparoscopic Nissen fundoplication. One hundred sixty-three patients with gastroesophageal
reflux disease underwent laparoscopic Nissen fundoplication with a median follow-up of 14 months (range 6 to 81 months). Preoperative
dysphagia was present in 37% (60 of 163) and was relieved in all but five patients (92%). Female sex (P = 0.01) and the presence of a stricture (P = 0.02) were the only preoperative variables associated with the presence of preoperative dysphagia. Eight percent (8 of
103) of patients without preoperative dysphagia developed new-onset dysphagia, and of these 63% (5 of 8) had a normal lower
esophageal sphincter (LES) (pressure >6 mm Hg; length >2 cm; abdominal length >1 cm). New-onset dysphagia was significantly
more common in patients with a normal LES (22% [5 of 23] vs. 4% [3 of 80], P = 001). Patients with a normal LES had almost a sixfold increase in the risk of developing dysphagia as those with an abnormal
LES (relative risk = 5.8). Only a preoperative normal LES (P = 0.02) or mean LES pressures (P = 0.04) were positively associated with the development of postoperative dysphagia. The severity of this dysphagia also showed
a strong positive trend of increasing with mean preoperative LES pressures (P = 0.07). Finally, preoperative LES pressure significantly correlated with postoperative LES pressure (r = 0.48, P = 0.01) and with mean residual LES (nadir) pressure (r = 0.33, P = 0.05) offering insight into the mechanism of this dysphagia. In conclusion, preoperative LES parameters play a role in
the development of dysphagia after laparoscopic Nissen fundoplication. Patients with a normal LES or high mean LES pressures
are at increased risk for developing this complication and should be informed of this before laparoscopic Nissen fundoplication.
Presented at the Forty-Second Annual Meeting of The Society for Surgery of the Alimentary Tract, Atlanta, Ga., May 20–23,
2001. 相似文献