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排序方式: 共有5998条查询结果,搜索用时 31 毫秒
71.
Stéphane Terry Ihsan Y. El-Sayed Damien Destouches Pascale Maillé Nathalie Nicolaiew Guillaume Ploussard Fannie Semprez Cynthia Pimpie Himisha Beltran Arturo Londono-Vallejo Yves Allory Alexandre de la Taille David S. Salomon Francis Vacherot 《Oncotarget》2015,6(14):11994-12008
Members of the EGF-CFC (Cripto, FRL-1, Cryptic) protein family are increasingly recognized as key mediators of cell movement and cell differentiation during vertebrate embryogenesis. The founding member of this protein family, CRIPTO, is overexpressed in various human carcinomas. Yet, the biological role of CRIPTO in this setting remains unclear. Here, we find CRIPTO expression as especially high in a subgroup of primary prostate carcinomas with poorer outcome, wherein resides cancer cell clones with mesenchymal traits. Experimental studies in PCa models showed that one notable function of CRIPTO expression in prostate carcinoma cells may be to augment PI3K/AKT and FGFR1 signaling, which promotes epithelial-mesenchymal transition and sustains a mesenchymal state. In the observed signaling events, FGFR1 appears to function parallel to AKT, and the two pathways act cooperatively to enhance migratory, invasive and transformation properties specifically in the CRIPTO overexpressing cells. Collectively, these findings suggest a novel molecular network, involving CRIPTO, AKT, and FGFR signaling, in favor of the emergence of mesenchymal-like cancer cells during the development of aggressive prostate tumors. 相似文献
72.
Guillaume Croville Charlotte Foret Pauline Heuillard Alexis Senet Mattias Delpont Mohammed Mouahid 《Avian pathology》2018,47(3):253-260
Respiratory syndromes (RS) are among the most significant pathological conditions in edible birds and are caused by complex coactions of pathogens and environmental factors. In poultry, low pathogenic avian influenza A viruses, metapneumoviruses, infectious bronchitis virus, infectious laryngotracheitis virus, Mycoplasma spp. Escherichia coli and/or Ornithobacterium rhinotracheale in turkeys are considered as key co-infectious agents of RS. Aspergillus sp., Pasteurella multocida, Avibacterium paragallinarum or Chlamydia psittaci may also be involved in respiratory outbreaks. An innovative quantitative PCR method, based on a nanofluidic technology, has the ability to screen up to 96 samples with 96 pathogen-specific PCR primers, at the same time, in one run of real-time quantitative PCR. This platform was used for the screening of avian respiratory pathogens: 15 respiratory agents, including viruses, bacteria and fungi potentially associated with respiratory infections of poultry, were targeted. Primers were designed and validated for SYBR green real-time quantitative PCR and subsequently validated on the Biomark high throughput PCR nanofluidic platform (Fluidigm©, San Francisco, CA, USA). As a clinical assessment, tracheal swabs were sampled from turkeys showing RS and submitted to this panel assay. Beside systematic detection of E. coli, avian metapneumovirus, Mycoplasma gallisepticum and Mycoplasma synoviae were frequently detected, with distinctive co-infection patterns between French and Moroccan flocks. This proof-of-concept study illustrates the potential of such panel assays for unveiling respiratory co-infection profiles in poultry. 相似文献
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Andreas Schlitzer Naomi McGovern Pearline Teo Teresa Zelante Koji Atarashi Donovan Low Adrian W.S. Ho Peter See Amanda Shin Pavandip Singh Wasan Guillaume Hoeffel Benoit Malleret Alexander Heiseke Samantha Chew Laura Jardine Harriet A. Purvis Catharien M.U. Hilkens John Tam Florent Ginhoux 《Immunity》2013,38(5):970-983
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Tim Segers Pieter Kruizinga Maarten P. Kok Guillaume Lajoinie Nico de Jong Michel Versluis 《Ultrasound in medicine & biology》2018,44(7):1482-1492
It has been proposed that monodisperse microbubble ultrasound contrast agents further increase the signal-to-noise ratio of contrast-enhanced ultrasound imaging. Here, the sensitivity of a polydisperse pre-clinical agent was compared experimentally with that of its size- and acoustically sorted derivatives by using narrowband pressure- and frequency-dependent scattering and attenuation measurements. The sorted monodisperse agents had up to a two-orders-of-magnitude increase in sensitivity, that is, in the average scattering cross section per bubble. Moreover, we found, for the first time, that the highly non-linear response of acoustically sorted microbubbles can be exploited to confine scattering and attenuation to the focal region of ultrasound fields used in clinical imaging. This property is a result of minimal pre-focal scattering and attenuation and can be used to minimize shadowing effects in deep tissue imaging. Moreover, it potentially allows for more localized therapy using microbubbles through the spatial control of resonant microbubble oscillations. 相似文献
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Michael H. McGillion Emmanuelle Duceppe Katherine Allan Maura Marcucci Stephen Yang Ana P. Johnson Sara Ross-Howe Elizabeth Peter Ted Scott Carley Ouellette Shaunattonie Henry Yannick Le Manach Guillaume Paré Bernice Downey Sandra L. Carroll Joseph Mills Andrew Turner Wendy Clyne P.J. Devereaux 《The Canadian journal of cardiology》2018,34(7):850-862
Worldwide, more than 230 million adults have major noncardiac surgery each year. Although surgery can improve quality and duration of life, it can also precipitate major complications. Moreover, a substantial proportion of deaths occur after discharge. Current systems for monitoring patients postoperatively, on surgical wards and after transition to home, are inadequate. On the surgical ward, vital signs evaluation usually occurs only every 4-8 hours. Reduced in-hospital ward monitoring, followed by no vital signs monitoring at home, leads to thousands of cases of undetected/delayed detection of hemodynamic compromise. In this article we review work to date on postoperative remote automated monitoring on surgical wards and strategy for advancing this field. Key considerations for overcoming current barriers to implementing remote automated monitoring in Canada are also presented. 相似文献
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