全文获取类型
收费全文 | 1113篇 |
免费 | 62篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 34篇 |
妇产科学 | 21篇 |
基础医学 | 137篇 |
口腔科学 | 102篇 |
临床医学 | 70篇 |
内科学 | 233篇 |
皮肤病学 | 60篇 |
神经病学 | 52篇 |
特种医学 | 77篇 |
外科学 | 78篇 |
综合类 | 26篇 |
预防医学 | 135篇 |
眼科学 | 26篇 |
药学 | 83篇 |
中国医学 | 4篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 5篇 |
2022年 | 17篇 |
2021年 | 28篇 |
2020年 | 23篇 |
2019年 | 30篇 |
2018年 | 36篇 |
2017年 | 18篇 |
2016年 | 38篇 |
2015年 | 45篇 |
2014年 | 48篇 |
2013年 | 60篇 |
2012年 | 89篇 |
2011年 | 109篇 |
2010年 | 59篇 |
2009年 | 33篇 |
2008年 | 67篇 |
2007年 | 58篇 |
2006年 | 50篇 |
2005年 | 44篇 |
2004年 | 30篇 |
2003年 | 21篇 |
2002年 | 19篇 |
2001年 | 14篇 |
2000年 | 5篇 |
1999年 | 13篇 |
1998年 | 22篇 |
1997年 | 24篇 |
1996年 | 16篇 |
1995年 | 11篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1990年 | 9篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 19篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1970年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有1181条查询结果,搜索用时 15 毫秒
101.
Pinto P Rocha P Veiga I Guedes J Pinheiro M Peixoto A Pinto C Fragoso M Sanches E Araújo A Alves F Coutinho C Lopes P Henrique R Teixeira MR 《Cancer genetics》2011,204(8):439-446
Cetuximab and panitumumab are two monoclonal antibodies targeting the epidermal growth factor receptor that have been approved for treatment of metastatic colorectal cancer. Recent clinical trials found an association between KRAS mutation status and resistance to anti-epidermal growth factor receptor therapy, leading to the recommendation to perform KRAS mutation analysis before cetuximab or panitumumab treatment. This study was designed to compare and evaluate the efficacy of four different methodologies--high resolution melting, Sanger sequencing, DxS kit, and SNaPshot--for KRAS mutation detection in a clinical setting. In total, 372 samples from patients with metastatic colorectal cancer were analyzed by high resolution melting and SNaPshot, with 184 of those being further analyzed by Sanger sequencing and 188 with the DxS kit. Sensitivities were compared after consensus findings were determined by the presence of the same result in two of the three methodologies used in each case. The frequency of KRAS codon 12 and 13 mutations in our population was 43.5%, and a discordant finding was observed in 22 samples. Comparing to Sanger sequencing, significantly more consensus mutations were detected by the DxS kit (P=0.0139), high resolution melting (P=0.0004), and SNaPshot (P=0.00001), but no statistically significant differences were found among the three methodologies with higher sensitivity. 相似文献
102.
Gonçalves DC Guedes JM Fonseca AM Martín I 《International journal of aging & human development》2010,71(2):153-166
The aim of the present study was to assess the psychometric properties of a version in Portuguese of the Reminiscence Functions Scale. Total sample was composed of 628 participants aged between 18 and 92 years, divided into three groups according to their age (18-24 years, n = 249; 26-54 years, n = 174; 55 and older, n = 205). Results indicated a five-factor solution for the Portuguese version of the Reminiscence Functions Scale, which accounted for 54% of the variance with good internal consistency (mean alpha = 0.86). Age and gender differences emerged regarding reminiscence functions. These results demonstrate that, while significant cultural differences exist, the psychometric properties of the Reminiscence Functions Scale are adequate for the Portuguese population. 相似文献
103.
Silvéria Regina de S. Lira Vietla Satyanarayana Rao Ana Carla S. Carvalho Marjorie M. Guedes Talita C. de Morais Antonia L. de Souza Maria Teresa S. Trevisan Alana F. Lima Mariana H. Chaves Flávia A. Santos 《Inflammopharmacology》2009,17(4):221-228
The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection
was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH),
and characterized using drugs that influence the endogenous prostaglandins, α2-adrenoceptors, nitric oxide, KATP-channels, and intracellular calcium. Orally administered lupeol (3, 10, and 30 mg/kg) significantly and dose-dependently
attenuated the ethanol-induced gastric damage by 39–69%, whereas the positive control N-acetylcysteine (NAC, 300 mg/kg, i.p.) afforded 32% protection. Both lupeol and NAC restored the NP-SH depleted by ethanol
but the lupeol effect was only marginal. Lupeol gastroprotection was attenuated by indomethacin and L-NAME, the respective
COX and NO-synthase inhibitors and was weakly sensitive to α2-adrenergic antagonist yohimbine and KATP-channel blocker glibenclamide, but more profoundly to calcium blocker verapamil. These pharmacological effects of lupeol
may synergistically contribute to alleviating the ethanol-associated gastric damage, which is multifactorial. 相似文献
104.
105.
106.
Dixit MP Nguyen C Carson T Guedes B Dixit NM Bell JM Wang Y 《Pediatric nephrology (Berlin, Germany)》2008,23(1):145-148
Acute tubulo-interstitial nephritis (ATIN) is an important cause of acute renal failure resulting from a variety of insults,
including immune complex-mediated tubulo-interstitial injury, but drugs such as non-steroidal anti-inflammatory drugs (NSAIDs)
are a far more frequent cause. Overall, as an entity, ATIN remains under-diagnosed, as symptoms resolve spontaneously if the
medication is stopped. We report on a 14-year-old boy who developed acute renal failure 2 weeks after aortic valve surgery.
He was put on aspirin following surgery and took ibuprofen for fever for nearly a week prior to presentation. He then presented
to the emergency department feeling quite ill and was found to have a blood urea nitrogen (BUN) concentration of of 147 mg/dl,
creatinine of 15.3 mg/dl and serum potassium of 8.7 mEq/l. Dialysis was immediately initiated. A kidney biopsy showed inflammatory
infiltrate consistent with ATIN. However, in the tubular basement membrane (TBM), very intense granular deposits of polyclonal
IgG and C3 were noted. He needed dialysis for 2 weeks and was treated successfully with steroids for 6 months. His renal recovery
and disappearance of proteinuria took a year. In conclusion, this is a first report of NSAIDs-associated ATIN, showing deposits
of granular immune complex present only in the TBM and not in the glomeruli. 相似文献
107.
BACKGROUND: Bariatric surgery for morbid obesity achieves an accentuated weight loss, with skin and soft tissue redundancy in some corporal segments, including the thighs. The thigh lift is a plastic surgery that improves this redundant tissue in the medial thigh area, but this surgical procedure may have complications, such as inferior migration of the scar, delayed wound healing, vulvar distortion, and lymphatic system alterations. METHODS: To evaluate the effect of the thighplasty on the lymphatic system, 14 patients were prospectively included in this study. Lymphoscintigraphy was performed before thighplasty, and this result was compared to the new examination performed 6 months after thighplasty. The exclusion standards include patients with clinical alterations and abnormal lymphoscintigraphy in previous surgery. RESULTS: The statistical analysis was performed on 26 inferior members, according to exclusion standards. All the members had normal lymphoscintigraphy in the preoperative period. After thighplasty, eight members (30.8%) demonstrated abnormal lymphoscintigraphy (p = 0.008) resulting in significant functional and anatomic alterations in the lymphatic system. CONCLUSION: The thigh lift changes lymphatic drainage in lower extremities according to lymphoscintigraphy analyses. 相似文献
108.
109.
110.
C. Désidéri-Vaillant Y. RoubyJ. Guedes C. KerdonkufE. Valero I. DrouillardH. Corbé P. Le Guen. 《Pathologie-biologie》2009
We have detected 410 microcytosis among biological tests of military people. These microcytosis are principally coumpounded by haemoglobin's abnormalities (minor thalassemia, sickle cell diseases, E haemoglobin cases and cases of C haemoglobin) and cases of iron deficiency, usually among women. 相似文献