全文获取类型
收费全文 | 343篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 38篇 |
妇产科学 | 6篇 |
基础医学 | 37篇 |
口腔科学 | 10篇 |
临床医学 | 60篇 |
内科学 | 39篇 |
皮肤病学 | 4篇 |
神经病学 | 9篇 |
特种医学 | 26篇 |
外科学 | 21篇 |
综合类 | 24篇 |
预防医学 | 24篇 |
眼科学 | 1篇 |
药学 | 17篇 |
中国医学 | 4篇 |
肿瘤学 | 15篇 |
出版年
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 7篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 23篇 |
2013年 | 23篇 |
2012年 | 15篇 |
2011年 | 8篇 |
2010年 | 14篇 |
2009年 | 15篇 |
2008年 | 7篇 |
2007年 | 9篇 |
2006年 | 17篇 |
2005年 | 5篇 |
2004年 | 6篇 |
2003年 | 13篇 |
2002年 | 4篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 2篇 |
1998年 | 13篇 |
1997年 | 18篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1958年 | 1篇 |
1957年 | 2篇 |
1956年 | 2篇 |
1954年 | 2篇 |
1952年 | 16篇 |
1951年 | 23篇 |
1950年 | 2篇 |
排序方式: 共有353条查询结果,搜索用时 0 毫秒
141.
JA Rauh-Hain M del Carmen NS Horowitz IA Alarcon E Ko AK Goodman AB Olawaiye 《BJOG : an international journal of obstetrics and gynaecology》2010,117(1):32-38
Objective To determine whether the presence of bowel obstruction at the time of initial presentation has any prognostic significance in these women.
Design Retrospective cohort study.
Setting Dedicated gynaecological oncology service of a large tertiary institution.
Population Women who had a bowel obstruction as part of their initial presentation of ovarian cancer were identified between 1995 and 2007. Each woman was matched with four control women (with disease but no obstruction).
Methods Women with disease were compared with controls to determine the impact, if any, of bowel obstruction at presentation. Several prognostic variables including bowel obstruction were also evaluated in a Cox proportional hazard model.
Main outcome measures Progression-free survival (PFS) and overall survival (OS).
Results Forty-eight women with disease and 192 controls were identified during the study period. The median follow-up period was 19 months among women with disease versus 20 months in controls. No differences were seen in demographics and clinical characteristics of the women. Optimal cytoreduction rate was similar between the two groups (75% versus 78%, P = 0.7). Patients with bowel obstruction had a shorter PFS and OS compared with controls [19 months versus 21 months ( P = 0.01) and 22 versus 35 months ( P = 0.008)], respectively. Bowel obstruction at presentation was an independent prognostic variable with a hazard ratio of 1.5 ( P = 0.009). Other prognostic variables were age, stage and extent of surgical cytoreduction.
Conclusions Bowel obstruction at the time of initial presentation is an adverse prognostic factor in women with ovarian cancer. 相似文献
Design Retrospective cohort study.
Setting Dedicated gynaecological oncology service of a large tertiary institution.
Population Women who had a bowel obstruction as part of their initial presentation of ovarian cancer were identified between 1995 and 2007. Each woman was matched with four control women (with disease but no obstruction).
Methods Women with disease were compared with controls to determine the impact, if any, of bowel obstruction at presentation. Several prognostic variables including bowel obstruction were also evaluated in a Cox proportional hazard model.
Main outcome measures Progression-free survival (PFS) and overall survival (OS).
Results Forty-eight women with disease and 192 controls were identified during the study period. The median follow-up period was 19 months among women with disease versus 20 months in controls. No differences were seen in demographics and clinical characteristics of the women. Optimal cytoreduction rate was similar between the two groups (75% versus 78%, P = 0.7). Patients with bowel obstruction had a shorter PFS and OS compared with controls [19 months versus 21 months ( P = 0.01) and 22 versus 35 months ( P = 0.008)], respectively. Bowel obstruction at presentation was an independent prognostic variable with a hazard ratio of 1.5 ( P = 0.009). Other prognostic variables were age, stage and extent of surgical cytoreduction.
Conclusions Bowel obstruction at the time of initial presentation is an adverse prognostic factor in women with ovarian cancer. 相似文献
142.
Women with advanced breast cancer and their spouses: diversity of support and psychological distress
Ilanit Hasson‐Ohayon Gil Goldzweig Michal Braun Daliah Galinsky 《Psycho-oncology》2010,19(11):1195-1204
Objective: The current study examines the effect of perceived support from different agents (spouse, family, friends, religion—spirituality) on psychological distress experienced by women with advanced breast cancer and their male spouses. Methods: In all, 150 couples consisting of women with advanced breast cancer and their spouses completed the Cancer Perceived Agent of Support Questionnaire and the Brief Symptom Inventory Scale. Results: Spouses reported more psychological distress (global, depression and anxiety) than patients. Both patients and spouses report a similar level of spousal support, and spouses reported a lower level of support provided from family and friends. Perceived support in the current study contributed significantly to the explanations of global psychological distress, depression and anxiety both for patients and their spouses. However, the specific agents of support that were significant in explaining these outcomes varied between patients and their spouses. For patients, family support received by both patient and partner was the most important source of support, protecting from psychological distress, while for the male partners, support from friends was most important. Religious‐based support was found to contribute negatively to the psychological distress of the patient and spouse. Conclusions: This study emphasizes the role of breast cancer spouses as care receivers in parallel to their role as caregivers, which is especially important in light of the high psychological distress reported by the spouses. The findings support the buffering effect, which different agents of support have against psychological distress while facing cancer for both patients and spouses. Patients and spouses differ with regard to the agents of support possessing this buffering effect. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
143.
非手术与桡骨短缩术治疗Kiebock氏病的疗效比较@J Salm on
@JK Stam ley
@IA T rail
@范少勇$江西中医学院!南昌330006 相似文献
144.
The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number of children in the care of each clinician was 4 (range 1-17) and the median number of children attending each hospital was 12 (range 5-23). All except one clinician arranged to confirm the diagnosis with a serum thyroid stimulating hormone concentration and free or total thyroxine. There was variation of opinion on the value of serum triiodothyronine and free triiodothyronine measurements, antibody screening, knee radiographs, and thyroid isotope scans. One clinician sought advice when notified of new children and two expressed the need for an investigation protocol. These findings indicate that most general paediatricians in East Anglia manage only a few children with CHT; the initial diagnosis is appropriately confirmed but they are uncertain about the value of other investigations. 相似文献
145.
146.
Jeppe Schultz Christensen Ole Raaschou-Nielsen Anne Tj?nneland Kim Overvad Rikke B. Nordsborg Matthias Ketzel Thorkild IA S?rensen Mette S?rensen 《Environmental health perspectives》2016,124(3):329-335
Background
Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight.Objectives
We aimed to investigate the relationship between residential traffic and railway noise and adiposity.Methods
In this cross-sectional study of 57,053 middle-aged people, height, weight, waist circumference, and bioelectrical impedance were measured at enrollment (1993–1997). Body mass index (BMI), body fat mass index (BFMI), and lean body mass index (LBMI) were calculated. Residential exposure to road and railway traffic noise exposure was calculated using the Nordic prediction method. Associations between traffic noise and anthropometric measures at enrollment were analyzed using general linear models and logistic regression adjusted for demographic and lifestyle factors.Results
Linear regression models adjusted for age, sex, and socioeconomic factors showed that 5-year mean road traffic noise exposure preceding enrollment was associated with a 0.35-cm wider waist circumference (95% CI: 0.21, 0.50) and a 0.18-point higher BMI (95% CI: 0.12, 0.23) per 10 dB. Small, significant increases were also found for BFMI and LBMI. All associations followed linear exposure–response relationships. Exposure to railway noise was not linearly associated with adiposity measures. However, exposure > 60 dB was associated with a 0.71-cm wider waist circumference (95% CI: 0.23, 1.19) and a 0.19-point higher BMI (95% CI: 0.0072, 0.37) compared with unexposed participants (0–20 dB).Conclusions
The present study finds positive associations between residential exposure to road traffic and railway noise and adiposity.Citation
Christensen JS, Raaschou-Nielsen O, Tjønneland A, Overvad K, Nordsborg RB, Ketzel M, Sørensen TI, Sørensen M. 2016. Road traffic and railway noise exposures and adiposity in adults: a cross-sectional analysis of the Danish Diet, Cancer, and Health cohort. Environ Health Perspect 124:329–335; http://dx.doi.org/10.1289/ehp.1409052 相似文献147.
148.
We have developed a self-regulating thermoseed for interstitial hyperthermia treatment of tumors. The seeds are made of a 70.4% nickel-29.6% copper alloy, and they have a Curie point at 50 degrees C. When exposed to an oscillating magnetic field (90 kHz, 50 Oersted amplitude), these seeds show a sharp drop in the rate of heat production at temperatures above the Curie point. In a simulated treatment of a small visceral mass that had negligible blood flow, the tissue temperature stabilized at the Curie point of the alloy with good temperature homogeneity throughout the volume heated by an array of thermoseeds. 相似文献
149.
Briggs NC Schlundt DG Levine RS Goldzweig IA Stinson N Warren RC 《American journal of preventive medicine》2006,31(2):135-141
BACKGROUND: Numerous reports have documented a lower prevalence of seat belt use among blacks in the United States, compared with whites. Limited data suggest that black-white disparities in states with primary seat belt laws (motorists can be stopped and cited solely for violating a seat belt law) are less marked than in states with secondary laws (motorists can be cited for violating a seat belt law only if stopped for another offense). METHODS: Data from the Fatality Analysis Reporting System were analyzed in 2005 to compare seat belt use among 11,574 blacks and 73,639 whites aged 16 or more years killed in crashes from 1999 to 2003 in 33 states with a primary or secondary adult seat belt law and annual reporting of race for 80% or more of decedents. After stratification of states by type of seat belt law, logistic regression was used to calculate odds ratios and 95% confidence intervals (CIs) for seat belt use among blacks, relative to whites, with adjustment for age, gender, seat position, urban/rural region, and income. RESULTS: Odds ratios and 95% CIs for seat belt use among blacks were 1.05 (0.97-1.13) and 0.89 (0.83-0.95), in primary- and secondary-law states, respectively. CONCLUSIONS: Black-white disparities in seat belt use were mitigated in states with primary seat belt laws. Only 24 states have primary laws. Enacting primary laws in other states might reduce or eliminate racial disparities in seat belt use. 相似文献
150.
Temperatureisanimportantfactorinfluencingthenervoussystem Forinstance ,coolingtherapyhasprotectiveeffectsonacutecerebralvasculardisease However,ifthetemperatureistooloworfluctuating ,itcanexacerbatenervepathology Thiswasconfirmedinmilitaryaccountsduringt… 相似文献