全文获取类型
收费全文 | 2487篇 |
免费 | 151篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 136篇 |
妇产科学 | 33篇 |
基础医学 | 322篇 |
口腔科学 | 42篇 |
临床医学 | 250篇 |
内科学 | 489篇 |
皮肤病学 | 56篇 |
神经病学 | 270篇 |
特种医学 | 215篇 |
外国民族医学 | 1篇 |
外科学 | 243篇 |
综合类 | 119篇 |
一般理论 | 1篇 |
预防医学 | 221篇 |
眼科学 | 26篇 |
药学 | 147篇 |
中国医学 | 7篇 |
肿瘤学 | 61篇 |
出版年
2021年 | 37篇 |
2019年 | 35篇 |
2018年 | 35篇 |
2017年 | 30篇 |
2016年 | 41篇 |
2015年 | 69篇 |
2014年 | 52篇 |
2013年 | 84篇 |
2012年 | 100篇 |
2011年 | 96篇 |
2010年 | 70篇 |
2009年 | 62篇 |
2008年 | 85篇 |
2007年 | 101篇 |
2006年 | 75篇 |
2005年 | 90篇 |
2004年 | 89篇 |
2003年 | 82篇 |
2002年 | 93篇 |
2001年 | 71篇 |
2000年 | 67篇 |
1999年 | 60篇 |
1998年 | 44篇 |
1997年 | 58篇 |
1996年 | 54篇 |
1995年 | 43篇 |
1994年 | 29篇 |
1993年 | 29篇 |
1992年 | 42篇 |
1991年 | 50篇 |
1990年 | 48篇 |
1989年 | 71篇 |
1988年 | 58篇 |
1987年 | 56篇 |
1986年 | 50篇 |
1985年 | 39篇 |
1984年 | 44篇 |
1983年 | 36篇 |
1982年 | 24篇 |
1981年 | 22篇 |
1980年 | 16篇 |
1979年 | 31篇 |
1978年 | 23篇 |
1977年 | 24篇 |
1976年 | 30篇 |
1975年 | 15篇 |
1974年 | 20篇 |
1973年 | 29篇 |
1972年 | 19篇 |
1971年 | 17篇 |
排序方式: 共有2651条查询结果,搜索用时 15 毫秒
81.
Champaneri S Xu X Carnethon MR Bertoni AG Seeman T Diez Roux A Golden SH 《Metabolism: clinical and experimental》2012,61(7):986-995
The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (β = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (β = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (β = 2.62; 95% CI, 0.72 to 4.51) (P = .02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P < .05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes. 相似文献
82.
Golden BA Jaskolka MS Ruiz RL 《Oral and maxillofacial surgery clinics of North America》2012,24(3):417-425
Dermoid cysts are congenital lesions that commonly arise from nondisjunction of surface ectoderm from deeper neuroectodermal structures. They tend to be found along planes of embryonic closure. Classification by site is helpful for diagnostic planning and surgical treatment. A distinction can be made between frontotemporal, orbital, frontoethmoidal, and calvarial lesions. The risk of extension into deeper tissues must be determined before surgical intervention. Simple lesions are amenable to direct excision. Deeper lesions often require a coordinated surgical approach between a neurosurgeon and craniofacial surgeon after thorough radiographic imaging. Follow-up through the developmental years is recommended for complex dermoid lesions. 相似文献
83.
Nadia K Magdalinou Hannah L Golden Jennifer M Nicholas Pirada Witoonpanich Catherine J Mummery Huw R Morris 《Neurocase》2013,19(4):204-212
ABSTRACTVerbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, progressive supranuclear palsy and corticobasal degeneration. All disease groups showed impaired verbal fluency and sentence generation versus healthy age-matched controls, after adjusting for general linguistic and executive factors. Dopaminergic stimulation in the Parkinson’s group selectively improved verbal generation versus other cognitive functions. Voxel-based morphometry identified left inferior frontal and posterior superior temporal cortical correlates of verbal generation performance. Verbal adynamia warrants further evaluation as an index of language network dysfunction and dopaminergic state in parkinsonian disorders. 相似文献
84.
Cathy Steel Allison Golden Joseph Kubofcik Nicole LaRue Tala de los Santos Gonzalo J. Domingo Thomas B. Nutman 《Clinical and Vaccine Immunology : CVI》2013,20(8):1155-1161
The Global Programme to Eliminate Lymphatic Filariasis has an urgent need for rapid assays to detect ongoing transmission of lymphatic filariasis (LF) following multiple rounds of mass drug administration (MDA). Current WHO guidelines support using the antigen card immunochromatographic test (ICT), which detects active filarial infection but does not detect early exposure to LF. Recent studies found that antibody-based assays better serve this function. In the present study, two tests, a rapid IgG4 enzyme-linked immunosorbent assay (ELISA) and a lateral-flow strip immunoassay, were developed based on the highly sensitive and specific Wuchereria bancrofti antigen Wb123. A comparison of W. bancrofti-infected and -uninfected patients (with or without other helminth infections) demonstrated that both tests had high sensitivities and specificities (93 and 97% [ELISA] and 92 and 96% [strips], respectively). When the W. bancrofti-uninfected group was separated into those with other filarial/helminth infections (i.e., onchocerciasis, loiasis, and strongyloidiasis) and those who were parasite uninfected, the specificities of the assays varied between 91 and 100%. In addition, the geometric mean response by ELISA of W. bancrofti-infected patients was significantly higher than the response of those without W. bancrofti infection (P < 0.0001). Furthermore, the Wb123 ELISA and the lateral-flow strips had high positive and negative predictive values, giving valuable information on the size of survey population needed to be reasonably certain whether or not transmission is ongoing. These highly sensitive and specific IgG4 tests to the W. bancrofti Wb123 protein give every indication that they will serve as useful tools for post-MDA monitoring. 相似文献
85.
86.
87.
目的分析先天性肠闭锁病例的诊断及治疗,以提高治愈率及术后生活质量。方法回顾性分析166例先天性肠闭锁的临床资料。结果治愈142例,治愈率85.5%(142/166),其中包括18例二期手术治愈者;术中10例、术后8例放弃治疗;术后死亡6例。结论早期诊断和选择合理的术式是提高肠闭锁治愈率的关键,基础支持及手术技术改进能促进病情的恢复,改善预后。 相似文献
88.
89.
Gober LM Eckman JA Sterba PM Vasagar K Schroeder JT Golden DB Saini SS 《The Journal of allergy and clinical immunology》2007,119(5):1181-1188
BACKGROUND: Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis. OBJECTIVE: The study's goals were to assess the baseline expression of activation markers on basophils in individuals with a sting reaction history, the degree of change in expression of these markers after intentional sting challenge, and the relationship between in vitro and in vivo activation marker expression. METHODS: Patients allergic to insect venom were enrolled and grouped by clinical category defined by a history of a systemic or large local reaction and use of venom immunotherapy. Blood was collected before and after sting challenge. Enriched basophils were analyzed for activation marker expression. In select subjects, basophils were examined after in vitro stimulation with insect venom for activation marker expression and histamine release. RESULTS: Of 35 sting-challenge participants, 21 provided adequate samples for analysis. Pre-sting basophil CD63 expression was significantly higher in systemic reactors on immunotherapy. Following sting challenge, the rise in basophil CD69 expression and CD203c was significantly higher in systemic reactors on immunotherapy. Levels of activation markers on basophils were greater after in vitro venom stimulation than after in vivo challenge. CONCLUSION: Broader shifts in expression of basophil activation markers after in vivo challenge occurred among subjects with a history of in vivo systemic anaphylaxis despite venom immunotherapy. CLINICAL IMPLICATIONS: Basophil activation markers may be potential biomarkers for anaphylaxis. 相似文献
90.
Clinical and laboratory factors contributing to uninterpretable beryllium lymphocyte proliferation tests (BeLPT) 下载免费PDF全文
Derek E. Smith MS Ashley P. Golden PhD Arthur W. Stange PhD Elizabeth Barker MPH Margaret Mroz MSPH Anna E. Barón PhD Debashis Ghosh PhD Lisa Maier MD Donna Cragle PhD Lee S. Newman MD MA 《American journal of industrial medicine》2018,61(7):592-604