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61.
Nieca Goldberg MD 《Current cardiovascular risk reports》2007,1(2):137-136
62.
63.
The increased awareness of the incidence and risk of coronary heart disease (CHD) has increased the efforts of physicians to identify women with CHD as early as possible. Exercise electrocardiogram (ECG) testing and imaging have been used in this manner for men and women but represent unique challenges with regard to women. Exercise ECG testing, which determines the presence of coronary artery disease by the provocation of ST depression and chest pain, has a lower positive predictive value in women than in men of the same age. This is explained by a lower prevalence of CHD in female patients with symptoms and (to a lesser extent) by the reported lower sensitivity and specificity of the test in women as compared with men. Exercise nuclear isotope myocardial perfusion imaging and exercise echocardiography have higher reported specificity and sensitivity, and new imaging agents, contrast echo agents, and acquisition protocols have reduced the limitations of these studies in selected women. The value of the exercise ECG examination with regard to CHD event risk assessment is equal in men and women and should be incorporated into the clinical evaluation of appropriate women patients. 相似文献
64.
Qiang Fu Karestan C Koenen Mark W Miller Andrew C Heath Kathleen K Bucholz Michael J Lyons Seth A Eisen William R True Jack Goldberg Ming T Tsuang 《Neuropsychopharmacology》2007,62(10):1088-1094
BACKGROUND: Epidemiologic studies reveal that posttraumatic stress disorder (PTSD) is highly comorbid with both conduct disorder and major depression in men. The genetic and environmental etiology of this comorbidity has not been examined. METHODS: Data were analyzed from 6744 middle-aged male-male monozygotic and dizygotic twins from the Vietnam Era Twin Registry. Conduct disorder, major depression, and PTSD were assessed via telephone interview using the Diagnostic Interview Schedule for the DSM-III-R in 1992. Structural equation modeling was used to estimate additive genetic, shared environmental, and individual-specific environmental effects common and specific to conduct disorder, major depression, and PTSD. RESULTS: The association between conduct disorder and PTSD was explained primarily by common shared environmental influences; these explained 10% (95% confidence interval: 6%-17%) of the variance in PTSD. The association between major depression and PTSD was largely explained by common genetic influences; these explained 19% (95% confidence interval: 11%-26%) of the variance in PTSD. CONCLUSIONS: Our findings suggest that different etiologic mechanisms explain the association of conduct disorder and major depression with PTSD in male veterans. If replicated in other populations, results suggest research aimed at identifying specific genetic and environmental factors that influence PTSD may benefit from starting with those that have been more consistently and strongly associated with major depression and conduct disorder. 相似文献
65.
66.
Biological and physical properties of autogenous vascularized fibular grafts in dogs 总被引:3,自引:0,他引:3
V M Goldberg S Stevenson J W Shaffer D Davy L Klein J Zika G Field 《The Journal of bone and joint surgery. American volume》1990,72(6):801-810
The biological and biomechanical properties of normal fibulae, fibulae that had had a sham operation, and both vascularized and non-vascularized autogenous grafts were studied in dogs at three months after the operation. The study was designed to quantify and correlate changes in these properties in orthotopic, stably fixed, weight-bearing grafts and to provide a baseline for additional studies of allografts. The grafts were eight centimeters long and internally fixed. The mechanical properties of the grafts were studied by torsional testing. Metabolic turnover of the grafts was evaluated by preoperative labeling of the dogs with 3H-tetracycline for resorption of bone mineral and with 3H-proline for turnover of collagen. Cortical bone area and porosity were measured. Postoperative formation of bone was evaluated by sequential labeling with fluorochrome. The vascularized grafts resembled the fibulae that had had a sham operation and those that had not had an operation with regard to the total number of osteons and the remodeling process, as measured both morphometrically and metabolically. The vascularized grafts were stronger and stiffer than the non-vascularized grafts and were not different from the bones that had had a sham operation. In contrast, the non-vascularized grafts were smaller, weaker, less stiff, and more porotic, had fewer osteons, and demonstrated increased turnover and resorption compared with the vascularized grafts, the bones that had had a sham operation, and the bones that had not been operated on. 相似文献
67.
W. E. Lieb D. A. Merton J. A. Shields S. M. Cohen D. D. Mitchell B. B. Goldberg 《The British journal of ophthalmology》1990,74(5):305-308
Colour Doppler imaging (CDI) is a recent development in ultrasonography. It allows simultaneous two-dimensional structural imaging and Doppler evaluation of blood flow. Quantitative information on flow velocity is obtained by pulsed Doppler spectral analysis, the colour information being used to choose the vessel of interest. Using this technique the authors examined a patient with an orbital varix previously diagnosed by clinical findings and computed tomography. Dynamic evaluation with real-time direct imaging of flow facilitated the diagnosis of this orbital disorder without the need for any contrast material. This technique may prove to be a useful adjunct to computed tomography for the evaluation of suspected vascular lesions of the orbit. 相似文献
68.
Alexander Goldberg Ursula Schlötzer-Schrehardt Theo Seiler 《International ophthalmology》1997,21(3):117-120
We report the first case of a unilateral microcysticMeesmann‘s epithelial dystrophy, observed in the left cornea of a 43-year-old
patient. The diagnosis was verified histologically by the unilateral occurrence of a ’peculiar substance‘ within epithelial
cysts and within the cytoplasm of the corneal epithelial cells. In an attempt to resolve thepatient‘s frequent corneal erosions,
we performed an autologous stem cell transplantation from the non-involved right eye. The results are, so far, satisfactory.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
69.
Nocturnal pains of the leg were the only complaint of a 2 1/2-year-old girl with recurrent dislocations of the left hip. Unusual movement during sleep probably caused the dislocations. This case represents a benign entity characterized by spontaneous or voluntary posterior dislocations of the femoral head in young children without other significant connective tissue abnormalities. 相似文献
70.
We have reported a case of severe erythema multiforme caused by outbreaks of recurrent HSV-2 infection. The EM was debilitating and responded to the treatment of HSV with oral acyclovir. On stopping the oral acyclovir, the HSV and the EM both recurred. We recommend a trial of oral acyclovir in cases of severe EM caused by recurrent HSV. 相似文献