全文获取类型
收费全文 | 5870篇 |
免费 | 368篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 132篇 |
妇产科学 | 195篇 |
基础医学 | 813篇 |
口腔科学 | 165篇 |
临床医学 | 775篇 |
内科学 | 1237篇 |
皮肤病学 | 86篇 |
神经病学 | 539篇 |
特种医学 | 109篇 |
外科学 | 529篇 |
综合类 | 30篇 |
一般理论 | 4篇 |
预防医学 | 683篇 |
眼科学 | 51篇 |
药学 | 340篇 |
中国医学 | 29篇 |
肿瘤学 | 517篇 |
出版年
2023年 | 46篇 |
2022年 | 82篇 |
2021年 | 184篇 |
2020年 | 99篇 |
2019年 | 153篇 |
2018年 | 144篇 |
2017年 | 122篇 |
2016年 | 132篇 |
2015年 | 163篇 |
2014年 | 201篇 |
2013年 | 310篇 |
2012年 | 439篇 |
2011年 | 508篇 |
2010年 | 244篇 |
2009年 | 231篇 |
2008年 | 399篇 |
2007年 | 381篇 |
2006年 | 385篇 |
2005年 | 346篇 |
2004年 | 361篇 |
2003年 | 329篇 |
2002年 | 291篇 |
2001年 | 44篇 |
2000年 | 45篇 |
1999年 | 55篇 |
1998年 | 56篇 |
1997年 | 53篇 |
1996年 | 32篇 |
1995年 | 30篇 |
1994年 | 31篇 |
1993年 | 28篇 |
1992年 | 20篇 |
1991年 | 27篇 |
1990年 | 17篇 |
1989年 | 14篇 |
1988年 | 21篇 |
1987年 | 19篇 |
1986年 | 22篇 |
1985年 | 9篇 |
1984年 | 27篇 |
1983年 | 19篇 |
1982年 | 20篇 |
1981年 | 18篇 |
1980年 | 17篇 |
1979年 | 9篇 |
1978年 | 12篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1973年 | 13篇 |
排序方式: 共有6271条查询结果,搜索用时 15 毫秒
71.
72.
Carla Palleis MD Matthias Brendel MD Anika Finze Endy Weidinger MD Kai Bötzel MD Adrian Danek MD Leonie Beyer MD Alexander Nitschmann Maike Kern Gloria Biechele Boris-Stephan Rauchmann MD Jan Häckert MD Matthias Höllerhage MD Andrew W. Stephens MD PhD Alexander Drzezga MD Thilo van Eimeren MD Victor L. Villemagne MD Andreas Schildan PhD Henryk Barthel MD Marianne Patt PhD Osama Sabri MD German Imaging Initiative for Tauopathies Peter Bartenstein MD Robert Perneczky MD Christian Haass PhD Johannes Levin MD Günter U. Höglinger MD 《Movement disorders》2021,36(9):2104-2115
73.
Gloria R. Grice Nicole M. Gattas Jill Sailors Julie A. Murphy Amy Tiemeier Peter Hurd Theresa Prosser Tricia Berry Wendy Duncan 《Patient education and counseling》2013
Objective
To assess whether student pharmacists’ communication skills improved using the Four Habits Model (FHM) at the St. Louis College of Pharmacy.Methods
During the Fall of 2009 and 2010, student pharmacists in the third professional year learned and practiced the FHM. They were given feedback by faculty on three of the four Habits, used the FHM for self and peer assessment, and were formally evaluated on all four Habits during a standardized patient encounter.Results
Student pharmacist performance significantly improved from baseline during both Fall 2009 and Fall 2010 in the majority of the Habits assessed.Conclusion
Use of the FHM in pharmacy education can improve a student pharmacists’ ability to display the four Habits of communicating and developing relationships with patients. Tailoring of the FHM to pharmacy encounters will further enhance the utility of this communication framework.Practice implications
Use of the FHM enhances the measurement and assessment of the relational aspects of student pharmacist–patient communication skills. Consistent use of the FHM over time is likely necessary to fully develop and retain communication skills. The overall goal is to improve patient's health literacy and appropriate medication use by improving communication and the pharmacist–patient relationship. 相似文献74.
Andreas E. Kremer Anita N. Kremer Carsten Willam Simon Völkl Johan Verhagen Susanne Achenbach Edith D. van der Meijden Vanessa Lang Michael Aigner Clara Maier Matthias Tenbusch Klaus Korn Gloria Lutzny-Geier Silvia Spoerl Richard Strauß Marcel Vetter Klaus Überla Markus F. Neurath Andreas Mackensen Mario Schiffer Holger Hackstein 《European journal of immunology》2021,51(10):2478-2484
Treatment with convalescent plasma has been shown to be safe in coronavirus disease in 2019 (COVID-19) infection, although efficacy reported in immunocompetent patients varies. Nevertheless, neutralizing antibodies are a key requisite in the fight against viral infections. Patients depleted of antibody-producing B cells, such as those treated with rituximab (anti-CD20) for hematological malignancies, lack a fundamental part of their adaptive immunity. Treatment with convalescent plasma appears to be of general benefit in this particularly vulnerable cohort. We analyzed clinical course and inflammation markers of three B-cell-depleted patients suffering from COVID-19 who were treated with convalescent plasma. In addition, we measured serum antibody levels as well as peripheral blood CD38/HLA-DR-positive T-cells ex vivo and CD137-positive T-cells after in vitro stimulation with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-derived peptides in these patients. We observed that therapy with convalescent plasma was effective in all three patients and analysis of CD137-positive T-cells after stimulation with SARS-CoV-2 peptides showed an increase in peptide-specific T-cells after application of convalescent plasma. In conclusion, we here demonstrate efficacy of convalescent plasma therapy in three B-cell-depleted patients and present data that suggest that while application of convalescent plasma elevates systemic antibody levels only transiently, it may also boost specific T-cell responses. 相似文献
75.
76.
Testing the Initial Efficacy of a Mailed Screening and Brief Feedback Intervention to Reduce At‐Risk Drinking in Middle‐Aged and Older Adults: The Comorbidity Alcohol Risk Evaluation Study 下载免费PDF全文
77.
Impact of Intraoperative Radiotherapy on Cosmetic Outcome and Complications after Oncoplastic Breast Surgery 下载免费PDF全文
Silvia Cracco MD Gloria Semprini MD Federico Cattin MD Giorgia Gregoraci MD Mark Zeppieri MD Miriam Isola MD Tino Ceschia MD Carla Cedolini MD Pier Camillo Parodi PhD 《The breast journal》2015,21(3):285-290
Breast cancer is one of the most common tumors in the population worldwide. Conservative breast surgery (CBS) is one of the preferred surgical options, because both the oncologic and esthetic needs of the patient can be addressed. CBS surgical outcomes tend to be more effective with reduced chances of disease recurrence when radiotherapy (RT) treatment is considered as an adjunct treatment, either applied during surgery (IORT) and/or after (EBRT). The purpose of our study was to compare surgical outcomes between IORT and EBRT after CBS. In the past 5 years, we performed CBS in 489 patients in our clinic. Of these patients, 83 underwent adjunct treatment with IORT and 109 were treated with EBRT in accordance with our university approved clinical protocol. Surgical outcomes, early complication rates, and esthetic results were compared between these two groups of CBS patients, with a mean follow‐up time of 17 months. IORT allowed breast irradiation treatment to be performed without effecting overlying skin, thus cosmetic outcomes tended to be favorable. Esthetic postoperative results assessed with the Breast Cancer Conservation Treatment (BCCTcore) software showed that the differences between IORT and EBRT were not statistically significant (including those patients that underwent further oncoplastic techniques after EBRT). The disease recurrence rates between the two groups were not significantly different. IORT is a safe, fast, and feasible technique that provides effective and comparable CBS outcomes for patients with breast cancer. 相似文献
78.
79.
Jonathan W. Riess Nupur Bhattacharya Kim R. M. Blenman Joel W. Neal Gloria Hwang Philippe Pultar 《Immunopharmacology and immunotoxicology》2014,36(2):182-186
Context: Talactoferrin alfa (TLF) is a unique recombinant form of human lactoferrin. The hypothesized mechanism of action involves TLF binding to the intestinal endothelium inducing dendritic cell maturation and cytokine release leading to infiltration of tumor with monocytes and T-lymphocytes and inhibition of tumor growth.Objective: Based on promising phase II trial results, this correlative study was undertaken to examine immune mechanism of action of TLF in metastatic non-small cell lung cancer (NSCLC) patients.Methods: Talactoferrin was administered orally at 1.5?g bid weeks 1–12 with 2 weeks off on a 14-week cycle. Enrolled patients had a pathologic diagnosis of NSCLC previously treated with at least two lines of systemic treatment. Patients had core biopsy of tumor before initiation of talactoferrin and at week 7 on TLF. Flow cytometry and quantitative immunohistochemistry for immune correlates were performed on the biopsied specimens.Results: Four patients with metastatic NSCLC were enrolled. The trial was halted pre-maturely in light of negative phase III trial results. For the two patients who had repeat on-treatment tumor biopsies, a consistent increase in monocytes as a percentage of total immune cells was observed. Otherwise, no clear trend of increase or decrease was observed in any other immune cell parameters compared to matched patient pre-treatment biopsies.Conclusion: Repeat biopsies for immune correlates by flow cytometry and quantitative immunohistochemistry in NSCLC patients are feasible. In the few patients sampled before trial closure, increased monocytes as a total percentage of the immune cell population within tumor was observed in response to TLF. 相似文献
80.
Luciana Ribeiro Serafim Jéssica Paôla Gonçalves da Silva Nívia Carolina Nogueira de Paiva Hudson Andrade dos Santos Maria da Gloria Quintão Silva Cláudia Martins Carneiro Sílvia Regina Costa Dias Élida Mara Leite Rabelo 《Parasitology research》2014,113(12):4611-4621
This study compared the course of Ancylostoma ceylanicum infection in hamsters infected with different inocula and the consequences for the host and helminth populations. The average of adult worms recovered, according to the number of third stage larva used, were 28.0, 24.8, 24.6, and 24.8 % to inocula size of 25 L3, 75 L3, 125 L3, and 250 L3, respectively. The size of the inoculum did not affect the establishment, survival, or fecundity of adult helminths. Reductions in the red blood cell and hemoglobin levels in the infected group were inversely proportional to the number of white blood cells. Moreover, differential cell counting revealed a positive correlation between the worm load and leucocyte numbers. The humoral response against excretion-secretion antigens was more robust and sensitive compared with the response against crude extract, with no direct linear correlation with the number of worms. The effect of the population density was more evident in females. 相似文献