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101.
Steckman DA Schneider PM Schuller JL Aleong RG Nguyen DT Sinagra G Vitrella G Brun F Cova MA Pagnan L Mestroni L Varosy PD Sauer WH 《The American journal of cardiology》2012,110(4):575-579
Some patients diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) are eventually found to have cardiac sarcoidosis (CS). Accurate differentiation between these 2 conditions has implications for immunosuppressive therapy and familial screening. We sought to determine whether cardiac magnetic resonance imaging (MRI) could be used to identify the characteristic findings to accurately differentiate between CS and ARVC. Consecutive patients with a diagnostic MRI scan indicating CS and/or ARVC constituted the cohort. All patients diagnosed with CS had histologic confirmation of sarcoidosis, and all patients with ARVC met the diagnostic task force criteria. The cardiac MRI data were retrospectively analyzed to identify possible differentiating characteristics. Of the patients, 40 had CS and 21 had ARVC. Those with CS were older and had more left ventricular scar. The presence of mediastinal lymphadenopathy or left ventricular septal involvement was seen exclusively in the patients with CS (p <0.001). A family history of sudden cardiac death was seen only in the ARVC group (p = 0.012). The right ventricular ejection fraction and ventricular volumes were also significantly different between the 2 groups. In conclusion, patients with CS have significantly different cardiac MRI characteristics than patients with ARVC. The cardiac volume, in addition to the degree and location of cardiac involvement, can be used to distinguish between these 2 disease entities. The presence of mediastinal lymphadenopathy and left ventricular septal scar favors a diagnosis of CS and not ARVC. Consideration of CS should be given if these MRI findings are observed during the evaluation for possible ARVC. 相似文献
102.
Park KL Budaj A Goldberg RJ Anderson FA Agnelli G Kennelly BM Gurfinkel EP Fitzgerald G Gore JM;Grace Investigators 《The American journal of cardiology》2012,110(5):628-635
The risk of stroke in patients hospitalized with an acute coronary syndrome (ACS) ranges from <1% to ≥2.5%. The aim of this study was to develop a simple predictive tool for bedside risk estimation of in-hospital ischemic stroke in patients with ACS to help guide clinicians in the acute management of these high-risk patients. Data were obtained from 63,118 patients enrolled from April 1999 to December 2007 in the Global Registry of Acute Coronary Events (GRACE), a multinational registry involving 126 hospitals in 14 countries. A regression model was developed to predict the occurrence of in-hospital ischemic stroke in patients hospitalized with an ACS. The main study outcome was the development of ischemic stroke during the index hospitalization for an ACS. Eight risk factors for stroke were identified: older age, atrial fibrillation on index electrocardiogram, positive initial cardiac biomarkers, presenting systolic blood pressure ≥160 mm Hg, ST-segment change on index electrocardiogram, no history of smoking, higher Killip class, and lower body weight (c-statistic 0.7). The addition of coronary artery bypass graft surgery and percutaneous coronary intervention into the model increased the prediction of stroke risk. In conclusion, the GRACE stroke risk score is a simple tool for predicting in-hospital ischemic stroke risk in patients admitted for the entire spectrum of ACS, which is widely applicable to patients in various hospital settings and will assist in the management of high-risk patients with ACS. 相似文献
103.
Cozzi F Parisi G Ciprian L Bullo A Cardarelli S Rizzo M Sfriso P Punzi L 《Rheumatology international》2012,32(5):1219-1223
Gastric involvement appears quite commonly in systemic sclerosis (SSc). The aim of this study was to evaluate gastric wall
motility using ultrasonography, a noninvasive method able to track both filling and emptying of fundus and antrum. The study
was performed in 20 SSc patients and 20 healthy control subjects. Gastric filling and emptying were evaluated by transabdominal
ultrasonography, measuring changes in fundus and antral areas over a 1-h period after ingestion of a liquid bolus (500 ml
of mineral water). Areas of both gastric fundus and antrum at basal evaluation were found to be smaller in SSc patients than
in healthy controls. Gastric filling was significantly reduced after ingestion of liquid bolus. Gastric emptying was delayed
both in fundus and antrum. No significant differences of gastric wall motility have been observed in different subsets of
SSc patients. Our findings show that gastric dysmotility is frequent and severe in SSc patients, contributing to the gastrointestinal
disturbances which are very common in this disease. 相似文献
104.
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106.
Giancarlo Di Gennaro Alfredo D’Aniello Marco De Risi Pier Paolo Quarato Addolorata Mascia Liliana G. Grammaldo Giulio N. Meldolesi Vincenzo Esposito Elisa Fabi Angelo Picardi 《Clinical neurophysiology》2013,124(8):1536-1540
ObjectiveThis study aims to assess the prognostic value of acute postoperative seizures (APOS) in patients surgically treated for drug-resistant extra-temporal lobe (ET) epilepsy.MethodsWe studied 77 consecutive patients with ET epilepsy who underwent epilepsy surgery and were followed up for at least 2 years (mean duration of follow-up 6.2 years, range 2–14). Medical charts were reviewed to identify APOS, defined as ictal events with the exception of auras occurring within the first 7 days after surgery. Seizure outcome was determined at annual intervals. Patients who were in Engel Class I at the last contact were classified as having a favourable outcome.ResultsSeizure outcome was favourable in 47 patients (61%). The occurrence of APOS and incompleteness of resection were found to be independently associated with unfavourable outcome in a multiple regression model including all preoperative factors identified as outcome predictors in univariate analysis. Duration of illness was the only independent preoperative predictor of APOS.ConclusionsOur study suggests that APOS may predict long-term outcome in patients undergoing resective surgery for ET epilepsy. Given some study limitations, our findings should be regarded as preliminary and need confirmation from future larger, prospective, multicentre studies.SignificanceCaution may be required in the clinical management of patients experiencing APOS. 相似文献
107.
Patrizia Dacci Stefano Amadio Simonetta Gerevini Lucia Moiola Ubaldo Del Carro Marta Radaelli Gianluca Figlia Vittorio Martinelli Giancarlo Comi Raffaella Fazio 《Neurological sciences》2013,34(3):393-396
Sciatic nerve traumatic damage very rarely occurs bilaterally. We describe the case of a 67-year-old woman who reported a bilateral traumatic lesion of the sciatic nerve during practice of yoga. Nerve conduction studies showed a bilateral sciatic nerve neuropathy, mostly affecting the peroneal component. Lumbar plexus MRI documented regular anatomical features of the main principal nerve roots with bilateral T2 signal alteration of roots L4, L5 and S1 that extended into the sciatic nerves showing both increase in size, probably related to chronic injury of nerves, and an alteration in diffusion signal that suggested a recent acute overlapped process. 相似文献
108.
Massimo Filippi Gianna Riccitelli Alessandro Meani Andrea Falini Giancarlo Comi Maria A. Rocca 《Brain structure & function》2013,218(5):1211-1227
An array of brain regions in the fronto-parietal and temporal lobes cooperates to process observation and execution of actions performed by other individuals. Using functional MRI, we hypothesized that vegetarians and vegans might show brain responses to mouth actions performed by humans, monkeys, and pigs different from omnivores. We scanned 20 omnivores, 19 vegetarians, and 21 vegans while watching a series of silent videos, which presented a single mouth action performed by a human, a monkey, and a pig. Compared to omnivores, vegetarians and vegans have increased functional connectivity between regions of the fronto-parietal and temporal lobes versus the cerebellum during observation of mouth actions performed by humans and, to the same degree, animals. Vegans also had increased connectivity with the supplementary motor area. During human mouth actions, increased amygdala activity in vegetarians and vegans was found. More critically, vegetarians recruited the right middle frontal gyrus and insula, which are involved in social mirroring, whereas vegans activated the left inferior frontal gyrus and middle temporal gyrus, which are part of the mirror neuron system. Monkey mouth actions triggered language network activity in both groups, which might be due to the attempt to decode monkey mouth gesture, with an additional recruitment of associative temporo-occipital areas in vegans, whereas pig mouth actions activated empathy-related regions, including the anterior cingulum. These results support the role of the action observation–execution matching system in social cognition, which enables us to interact not only with our conspecifics but also with species in phylogenetic proximity to humans. 相似文献
109.
Mario Bonomini Lorenzo Di Liberato Goffredo Del Rosso Antonio Stingone Giancarlo Marinangeli Agostino Consoli Silvio Bertoli Amedeo De Vecchi Emanuele Bosi Roberto Russo Roberto Corciulo Loreto Gesualdo Francesco Giorgino Paolo Cerasoli Augusto Di Castelnuovo Maria Pia Monaco Ty Shockley Claudia Rossi Arduino Arduini 《American journal of kidney diseases》2013
110.
Paoloni M Fratocchi G Mangone M Murgia M Santilli V Cacchio A 《Clinical rheumatology》2012,31(3):535-539
Patellofemoral pain syndrome (PFPS) is a common source of anterior knee pain. While treatment for PFPS may be successful in
the short term, long-term results are less promising. The purpose of this study was to record long-term pain and functionality
outcomes following rehabilitation in patients affected by PFPS. A prospective cohort study of 44 patients with a diagnosis
of PFPS and an activation imbalance between the vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles were enrolled.
Patients underwent patellar taping (2 weeks) followed by a rehabilitation program lasting until the end of the third month.
Primary outcome measures were pain and the functional level of the patellofemoral joint. Secondary outcome measures were surface
electromyographic (sEMG) onset timing of the VMO/VL during seated knee extension and squat and isometric knee extensor muscle
strength. Significant differences in all the outcome measures were observed between the affected and unaffected sides before
treatment. The pain score significantly decreased both posttreatment (Δ = −4.7; 95% CI = −5.4 to −3.9) and at the 12-month
follow-up (Δ = −5.5; 95% CI = −6.1 to −4.8), while the functional level significantly increased both posttreatment (Δ = 24;
95% CI = 18.3 to 30.2) and at the 12-month follow-up (Δ = 26; 95% CI = 21.4 to 30.6). Posttreatment, 35/44 patients (79.5%)
and 31/44 patients (70.5%) achieved normal sEMG onset timing of the VMO and VL in the seated knee extension exercise and in
the squat exercise, respectively. A short period of patellar taping followed by an exercise program results in long-lasting
pain control in PFPS associated with muscular dysfunction. 相似文献