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51.
Inhibition of intercellular adhesion molecule-1 (ICAM-1), soluble ICAM-1 and interleukin-4 by nitric oxide expression in migraine patients 总被引:2,自引:0,他引:2
P. Martelletti Giuseppe Stirparo Stefania Morrone Cristina Rinaldi Mario Giacovazzo 《Journal of molecular medicine (Berlin, Germany)》1997,75(6):448-453
The mechanisms of the postulated ”sterile” inflammation in migraine were studied utilizing flow cytometry (intercellular
adhesion molecule 1, ICAM-1; interleukin-1 receptor, IL-1R) and enzyme-linked immunosorbent assay (soluble intercellular adhesion
molecule 1, sICAM-1; interleukin-4, IL-4). Twenty patients suffering from migraine without aura, 20 healthy subjects, and
10 patients suffering from episodic tension headache were selected. All of the migraine patients were studied during a migraine
crisis experimentally induced by the administration of isosorbide dinitrate (a nitric oxide donor), and 10 out the 20 were
also studied during a spontaneous migraine attack. A sharp decrease in the expression of ICAM-1 (F=5.09, p<0.001 and F=2.46, p<0.05, respectively), sICAM-1 1 (F=6.21, p<0.0001 and F=3.99, p<0.007, respectively) and serum IL-4 (F=6.23, p<0.001 and F=3.64, p<0.01, respectively) were observed in experimentally induced and spontaneous migraine attacks. There was no change with respect
to IL-IR 1 receptor expression values. The two control groups, tested with the same experimental procedure, showed no changes
in ICAM-1 and IL-1R or in in sICAM-1 and IL-4. Our data suggest that migraine patients are more sensitive to exogenous NO
than controls. In addition, our results indicate that experimental migraine crisis, induced by an NO donor, is mediated by
the inhibition of IL-4 and subsequently of ICAM-1. It is likely that the described ICAM-1 downregulation inhibits during a
migraine attack the critical step of transendothelial migration into the cerebral tissues of activated leukocytes, as proposed
in the ”sterile inflammation” hypothesis.
Received: 17 April 1996 / Accepted: 30 December 1996 相似文献
52.
Paolo Martelletti Massimo Granata Mario Giacovazzo 《Cephalalgia : an international journal of headache》1993,13(5):343-345
We measured serum interleukin-l beta (IL-1 beta) in 24 episodic cluster headache (CH) patients and 45 normal controls using a specific ELISA method. There was an increase in IL-1 beta in all CH patients compared to controls. IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals. Between attacks, IL-1 beta was also significantly increased compared to controls. We suggest that these results represent an activation of the immune system in CH. 相似文献