全文获取类型
收费全文 | 3631篇 |
免费 | 170篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 50篇 |
妇产科学 | 95篇 |
基础医学 | 425篇 |
口腔科学 | 183篇 |
临床医学 | 266篇 |
内科学 | 798篇 |
皮肤病学 | 111篇 |
神经病学 | 400篇 |
特种医学 | 120篇 |
外科学 | 556篇 |
综合类 | 32篇 |
预防医学 | 285篇 |
眼科学 | 43篇 |
药学 | 190篇 |
中国医学 | 21篇 |
肿瘤学 | 223篇 |
出版年
2023年 | 24篇 |
2022年 | 55篇 |
2021年 | 109篇 |
2020年 | 52篇 |
2019年 | 75篇 |
2018年 | 97篇 |
2017年 | 75篇 |
2016年 | 60篇 |
2015年 | 88篇 |
2014年 | 147篇 |
2013年 | 148篇 |
2012年 | 256篇 |
2011年 | 280篇 |
2010年 | 165篇 |
2009年 | 132篇 |
2008年 | 253篇 |
2007年 | 231篇 |
2006年 | 205篇 |
2005年 | 185篇 |
2004年 | 181篇 |
2003年 | 159篇 |
2002年 | 169篇 |
2001年 | 59篇 |
2000年 | 60篇 |
1999年 | 53篇 |
1998年 | 25篇 |
1997年 | 41篇 |
1996年 | 24篇 |
1995年 | 16篇 |
1994年 | 13篇 |
1993年 | 10篇 |
1992年 | 35篇 |
1991年 | 23篇 |
1990年 | 27篇 |
1989年 | 34篇 |
1988年 | 17篇 |
1987年 | 17篇 |
1986年 | 20篇 |
1985年 | 18篇 |
1984年 | 20篇 |
1983年 | 19篇 |
1982年 | 11篇 |
1980年 | 12篇 |
1979年 | 16篇 |
1976年 | 10篇 |
1974年 | 8篇 |
1973年 | 10篇 |
1972年 | 8篇 |
1971年 | 8篇 |
1969年 | 8篇 |
排序方式: 共有3827条查询结果,搜索用时 11 毫秒
91.
Laura Villarreal‐Martínez Jaime García‐Chvez Berenice Snchez‐Jara Aida Mashenka Moreno‐Gonzlez Janet Soto‐Padilla Efraín Aquino‐Fernndez Rogelio Paredes‐Aguilera Karla Maldonado‐Silva Cecilia Rodríguez‐Castillejos Ana Itamar Gonzlez‐vila María Mora‐Torres Hector Manuel Tiznado‐García Natalia Elizabeth Padilla‐Durn Nuria Citlali Luna‐Silva Eric Israel Gutirrez‐Jurez Jorge Nemi‐Cueto Claudia Sofia Gmez‐Gonzlez Ricardo De Len‐Figueroa Adela Lpez‐Miranda Mirna Guadalupe Ríos‐Osuna Edna Liliana Tamez‐Gmez Elio Aarn Reyes‐Espinoza Irving Armando Domínguez‐Varela Gerardo Gonzlez‐Martínez Elias Adn Godoy‐Salinas 《Haemophilia》2020,26(2):290-297
92.
Fabio Pagni Marta Jaconi Alberto Delitala Mattia Garancini Matteo Maternini Francesca Bono Alessandro Giani Andrew Smith the San Gerardo Hospital collaborators group 《Endocrine pathology》2014,25(3):288-296
The recent increase in the detection of papillary thyroid carcinoma (PTC) has been influenced by the finding of incidental tumours. To this group, carcinomas measuring less than 1 cm (the so-called microcarcinomas) as well as those above 1 cm belong. Analyzing a case series from our own experience, this paper focuses on the current pre-operative diagnostic challenges that can lead to PTC incidental discovery. For this retrospective study, 287 patients with a PTC diagnosis were selected. For each, the following variables were analysed: sex, age, ultrasound (US) appearance, number of thyroid nodules, PTC size, PTC variants and presence of other associated pathology. Pre-operative fine needle aspiration (FNA) results were classified according to the five-tiered SIAPEC system. For 281 patients, the US-guided FNA results were available. Cytohistological correlation was evaluated in terms of FNA sensitivity and false negative rate. An incidental PTC was found in 45.2 % of patients. The majority of these were due to unsuccessful US detection of malignant nodules (103 cases); incorrect cytological diagnosis was responsible for the other 24 cases. The most powerful clinical confounding factors were: multinodular background versus single nodule presentations (p?0.001) and histotype (follicular vs conventional variant, p?0.05). Of course, tumour size remains a strongly influential feature on pre-operative diagnosis, with greater difficulties arising for carcinomas <5 mm. Moreover, FNA sensitivity was lower also in large PTCs (>2 cm) due to tumour heterogeneity. Although with limitations related to the tumour’s intrinsic features and the thyroid background, US-guided FNA, especially if performed by a dedicated multidisciplinary team, is a powerful diagnostic tool for detecting malignant thyroid nodules. To the state of the art, we propose a practical clinical-pathological cut-off for this procedure, setting it at 5 mm. 相似文献
93.
Castañeda-Bueno M Cervantes-Pérez LG Vázquez N Uribe N Kantesaria S Morla L Bobadilla NA Doucet A Alessi DR Gamba G 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(20):7929-7934
Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4 modulates the activity of the renal Na(+)Cl(-) cotransporter, NCC. Because the renal consequences of WNK4 carrying pseudoaldosteronism type II mutations resemble the response to intravascular volume depletion (promotion of salt reabsorption without K(+) secretion), a condition that is associated with high angiotensin II (AngII) levels, it has been proposed that AngII signaling might affect WNK4 modulation of the NCC. In Xenopus laevis oocytes, WNK4 is required for modulation of NCC activity by AngII. To demonstrate that WNK4 is required in the AngII-mediated regulation of NCC in vivo, we used a total WNK4-knockout mouse strain (WNK4(-/-)). WNK4 mRNA and protein expression were absent in WNK4(-/-) mice, which exhibited a mild Gitelman-like syndrome, with normal blood pressure, increased plasma renin activity, and reduced NCC expression and phosphorylation at T-58. Immunohistochemistry revealed normal morphology of the distal convoluted tubule with reduced NCC expression. Low-salt diet or infusion of AngII for 4 d induced phosphorylation of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and of NCC at S-383 and T-58, respectively, in WNK4(+/+) but not WNK4(-/-) mice. Thus, the absence of WNK4 in vivo precludes NCC and SPAK phosphorylation promoted by a low-salt diet or AngII infusion, suggesting that AngII action on the NCC occurs via a WNK4-SPAK-dependent signaling pathway. Additionally, stimulation of aldosterone secretion by AngII, but not by a high-K(+) diet, was impaired in WNK4(-/-) mice. 相似文献
94.
95.
96.
97.
The use of a 2-stage inlay technique in atrophic posterior mandibles with more than 10-mm thickness and less than 5-mm height above the inferior alveolar nerve is described. The first surgical procedure was a basic corticotomy of the buccal and lingual bone. One month later, a complete inlay procedure was performed. Computed tomography and conventional radiography showed a mean vertical bone gain of 11.5 mm. This 2-stage inlay technique avoids the use of chisels to complete bone osteotomy and reduces postsurgical nerve disturbances in atrophic posterior mandibles. This technique reduces intraprocedure and postoperative patient discomfort. 相似文献
98.
99.
Eliú Elgorriaga-Islas Piero Guggiana-Nilo Mariana Domínguez-Yévenes Gerardo González-Rocha Sergio Mella-Montecinos Jaime Labarca-Labarca Patricia García-Cañete Helia Bello-Toledo 《Enfermedades infecciosas y microbiología clínica》2012
Introduction
The frequency of aac(6′)-Ib-cr gene in ESBL-producing strains of Klebsiella pneumoniae and Escherichia coli is unknown, in Chile.Methodology
The aac(6′)-Ib and aac(6’)-Ib-cr genes were investigated using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and sequencing, in strains isolated from 10 Chilean hospitals between 2008-2009.Results
The aac(6’)-Ib-cr gene was detected in 54% of K. pneumoniae and 74% of E. coli strains. The CIM50 of CIP was higher among strains harboring aac(6’)-Ib-cr, 8 times higher in K. pneumoniae and 4 times higher in E. coli. Moreover, both aac(6’)-Ib and aac(6’)-Ib-cr were simultaneously found in 13 K. pneumoniae and 3 E. coli isolates.Conclusion
This is the first report of aac(6’)-Ib-cr in ESBL-producing strains of K. pneumoniae and E. coli isolated from in-patients in Chilean hospitals located along an area of more than 2,800 Km. 相似文献100.
Tamás Treuer MD PhD Chia‐Yih Liu MD Gerardo Salazar MD Ronnachai Kongsakon MD MSc Fujun Jia PhD Hussain Habil MD Min‐Soo Lee MD PhD Amanda Lowry BSc Hons Héctor Dueñas MD 《Asia-Pacific psychiatry》2013,5(4):219-230
Major depressive disorder is prevalent worldwide, and only about half of those affected will experience no further episodes or symptoms. Additionally, depressive symptoms can be challenging to identify, with many patients going undiagnosed despite a wide variety of available treatment options. Antidepressants are the cornerstone of depression treatment; however, a large number of factors must be considered in selecting the treatment best suited to the individual. To help support physicians in this process, international and national treatment guidelines have been developed. This review evaluates the current use of antidepressant treatment for major depressive disorder in six Asian countries (China, Korea, Malaysia, Philippines, Taiwan, and Thailand). No remarkable differences were noted between Asian and international treatment guidelines or among those from within Asia as these are adapted from western guidelines, although there were some local variations. Importantly, a shortage of evidence‐based information at a country level is the primary problem in developing guidelines appropriate for Asia, so most of the guidelines are consensus opinions derived from western research data utilized in western guidelines. Treatment guidelines need to evolve from being consensus based to evidence based when evidence is available, taking into consideration cost/effectiveness or cost/benefit with an evidence‐based approach that more accurately reflects clinical experience as well as the attributes of each antidepressant. In everyday practice, physicians must tailor their treatment to the patient's clinical needs while considering associated external factors; better tools are needed to help them reach the best possible prescribing decisions which are of maximum benefit to patients. 相似文献