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41.
Cruz-Correa M Schultz K Jagannath S Harris M Kantsevoy S Bedine M Kalloo AN 《Digestive diseases and sciences》2007,52(4):1009-1013
We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic
catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≥50 years old received
three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity,
specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated.
The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar
for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile
similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was
slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance. 相似文献
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Sumiyama K Gostout CJ Rajan E Bakken TA Knipschield MA Chung S Cotton PB Hawes RH Kalloo AN Kantsevoy SV Pasricha PJ 《Gastrointestinal endoscopy》2007,65(7):1028-1034
BACKGROUND: Transgastric cholecystectomy is thought to technically and anatomically challenge a single entry flexible endoscopic approach. OBJECTIVES: To examine the feasibility of a transgastric-only cholecystectomy, endoscope performance in an upper-abdominal operation, and the usefulness of an offset gastrotomy. STUDY DESIGN: Animal survival study. SETTING: Animal research laboratory. PATIENTS: Six domestic pigs. MAIN OUTCOME MEASUREMENTS: Transgastric access to the gallbladder and technical feasibility of unassisted transgastric cholecystectomy. INTERVENTIONS: A cephalad submucosal tunnel was created in the anterior gastric wall with a high-pressure CO2 injection. An EMR-cap myotomy was performed distally within the submucosal space and created an offset gastrotomy. An endoscope was inserted into the peritoneal cavity through the myotomy. Access to the gallbladder was compared by using a multibending therapeutic endoscope (R-scope), with a standard double-channel endoscope. A cholecystectomy was performed by using both types of endoscopes. The myotomy site was sealed with the overlying mucosal flap. The mucosal entry point was closed with clips or tissue anchors. RESULTS: A standard double-channel endoscope could access the gallbladder in 2 of 4 attempts. A multibending endoscope accessed the gallbladder in all 4 attempts, including 2 pigs in which the standard scope failed to access the gallbladder. In 4 pigs, a cholecystectomy was completed. Two pigs died during surgery, with air embolization observed in 1. Two pigs survived a planned 1-week survival period. CONCLUSIONS: Transgastric cholecystectomy is technically feasible. Transgastric access to the gallbladder may be improved by using submucosal endoscopy with an offset exit gastrotomy by means of the mucosal flap safety-valve technique and a multibending gastroscope. 相似文献
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Meireles OR Kantsevoy SV Assumpcao LR Magno P Dray X Giday SA Kalloo AN Hanly EJ Marohn MR 《Surgical endoscopy》2008,22(7):1609-1613
Background Reliable closure of the translumenal incision is one of the main challenges facing natural orifice translumenal endoscopic
surgery (NOTES). This study aimed to evaluate the use of an automated flexible stapling device (SurgASSIST) for closure of
the gastrotomy incision in a porcine model.
Methods A double-channel gastroscope was advanced into the stomach. A gastric wall incision was made, and the endoscope was advanced
into the peritoneal cavity. After peritoneoscopy, the endoscope was withdrawn into the stomach. The SurgASSIST stapler was
advanced orally into the stomach. The gastrotomy edges were positioned between the opened stapler arms using two endoscopic
grasping forceps. Stapler loads with and without a cutting blade were used for gastric closure. After firing of the stapler
to close the gastric wall incision, x-ray with contrast was performed to assess for gastric leakage. At the end of the procedure,
the animals were killed for a study of closure adequacy.
Results Four acute animal experiments were performed. The delivery and positioning of the stapler were achieved, with technical difficulties
mostly due to a short working length (60 cm) of the device. Firing of the staple delivered four rows of staples. Postmortem
examination of pig 1 (when a cutting blade was used) demonstrated full-thickness closure of the gastric wall incision, but
the cutting blade caused a transmural hole right at the end of the staple line. For this reason, we stopped using stapler
loads with a cutting blade. In the three remaining animals (pigs 2–4), we were able to achieve a full-thickness closure of
the gastric wall incision without any complications.
Conclusions The flexible stapling device may provide a simple and reliable technique for lumenal closure after NOTES procedures. Further
survival studies are currently under way to evaluate the long-term efficacy of gastric closure with the stapler after intraperitoneal
interventions.
Presented in part at the Society of American Gastrointestinal Endoscopic Surgeons (SAGES) Annual Meeting, Las Vegas, Nevada,
April 2007. 相似文献
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Puri A Khaliq T Rajendran SM Bhatia G Chandra R Narender T 《Journal of herbal pharmacotherapy》2007,7(1):59-64
Indigofera tinctoria is a perennial shrub, which belongs to the family Papilionaceae. As a part of our drug discovery program we have investigated the antidyslipidemic activity of the alcoholic extract from Indigofera tinctoria as well as its three other components, that is, chloroform, butanol and aqueous fractions in dyslipidemic hamsters that were fed a high fat diet. The chloroform fraction showed a significant decrease in the plasma triglycerides (TG, 52%) (P < 0.001), total cholesterol (TC, 29%) (P < 0.05), glycerol (Gly, 24%) and free fatty acids (FFA, 14%). This decrease was also accompanied by an increase in high density lipoproteins (HDL) by 9% and an increased HDL-C/TC ratio of 52% at the dose of 250 mg/kg of body weight. 相似文献
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