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Oxytocin,Vasopressin and Related Peptides in the Regulation of Behavior. Edited by Elena Choleris,Donald W. Pfaff,and Martin Kavaliers. ix + 393 pp. Cambridge,UK: Cambridge University Press. 2013. $110.00 (cloth), $88.00 (e‐book).
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Geert J. de Vries 《American journal of human biology》2014,26(3):434-435
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Gerrit A. van Essen Jiri Beran Jeanne‐Marie Devaster Christelle Durand Xavier Duval Meral Esen Ann R. Falsey Gregory Feldman Pierre Gervais Bruce L. Innis Martina Kovac Odile Launay Geert Leroux‐Roels Janet E. McElhaney Shelly McNeil Mohammed Oujaa Jan Hendrik Richardus Guillermo Ruiz‐Palacios Richard H. Osborne Lidia Oostvogels 《Influenza and other respiratory viruses》2014,8(4):452-462
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NB Eloy N Gonzalez J Van Leene K Maleux H Vanhaeren L De Milde S Dhondt L Vercruysse E Witters R Mercier L Cromer GT Beemster H Remaut MC Van Montagu G De Jaeger PC Ferreira D Inzé 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(34):13853-13858
The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regulatory proteins, including the destruction of mitotic cyclins at the metaphase-to-anaphase transition. Despite its importance, the role of the APC/C in plant cells and the regulation of its activity during cell division remain poorly understood. Here, we describe the identification of a plant-specific negative regulator of the APC/C complex, designated SAMBA. In Arabidopsis thaliana, SAMBA is expressed during embryogenesis and early plant development and plays a key role in organ size control. Samba mutants produced larger seeds, leaves, and roots, which resulted from enlarged root and shoot apical meristems, and, additionally, they had a reduced fertility attributable to a hampered male gametogenesis. Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis. 相似文献
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Van Mieghem W Mairesse G Missault L Vanhooren G Verhamme P Dupont A 《Acta cardiologica》2012,67(2):161-167
Stroke is the most common cardiovascular disorder after heart disease, with a high mortality and often poor quality of life in survivors. Atrial fibrillation (AF), the most commonly occurring sustained cardiac arrhythmia increases the risk of stroke by five. However, stroke risk is not homogeneous and varies with associated morbidities and risk factors. Risk assessment scores have been developed and according to the calculated level of risk, guidelines recommend treatment with antithrombotic agents, preferably vitamin K antagonists (VKA). Despite these recommendations many patients with AF do not receive adequate thromboprophylaxis. The presence of AF is often not recognized and VKA are underused due to doctor- or patient-related factors and intrinsic disadvantages of these drugs. An awareness campaign for the diagnosis of AF is warranted, highlighting the risk of stroke. Novel anticoagulants that largely overcome many of the limitations of vitamin K antagonists are becoming available. 相似文献
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Lambert G.M. de Bont Robert S.B. Liem Peter Havinga Geert Boering 《Cranio : the journal of craniomandibular practice》2013,31(4):368-373
This article describes the spatial arrangement of collagen fibrils in the articular disk of the normal human temporomandibular joint (TMJ). Disks obtained at necropsy were examined by light microscopy and scanning electron microscopy. Observations by light microscopy showed dense cartilaginous tissue composed of collagen fiber bundles running in all directions. Observations by scanning electron microscopy revealed a network of collagen fibrils which were predominantly organized in bundles. In the surface layers an anteroposterior orientation was detectable. The authors concluded that the fibrous component of the TMJ articular disk is composed of collagen fibrils, organized in a three-dimensional network and able to resist compression forces due to loading. 相似文献
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Paul Koole Floris Beenhakker Tonny J. Brongersma Henry J. de Jongh Geert Boering 《Cranio : the journal of craniomandibular practice》2013,31(4):326-332
The patient described in this article suffered from pain in the right side of her face for five years before she saw the authors. Earlier treatment with medication and neurosurgery had not been successful. The authors used electromyography to examine the disturbed muscle function and to investigate a possible cause for the pain in the muscles of mastication. The silent periods of the patient's muscles were measured before and after treatment, since it is known from the literature that the EMG silent periods may be elongated in patients with TMJ dysfunction or occlusal irregularities. The coordination of both heads of this patient's lateral pterygoid muscles were bilaterally investigated before and after treatment. Treatment consisted of splint therapy and selective grinding. Oral rehabilitation was also undertaken, beginning three months after the disappearance of the patient's symptoms. 相似文献