Über die Eiweißkörper des Blutes bei experimenteller Leberschädigung durch die Eck-Fistel

Zusammenfassung Bei experimenteller Leberzellschädigung durch Eckfistel und Fleischintoxikation wird eine Verschiebung der Bluteiweißkörper im Sinne einer erheblichen Fibrinogen- und Globulinvermchrung gefunden. Diese Vermehrung wird durch mechanische Ausschaltung des Pfortaderkreislaufs bei gleichzeitigem Darniederliegen der Leberfunktion verursacht.Aus der Wirksamkeit eines toxischen Reizes (Fleischintoxikation) auf die Plasmabildungsstätten wird geschlossen, daß auch eine extrahepatische Plasmabildung möglich ist. Als Ort der Bildungsstätte wird das reticuloendotheliale System angenommen.Mit 1 Textabbildung.     

über die nachbehandlung von knochenbrüchen,besonders des speichenbruches,zumal seiner nebenschÄdigungen

Zusammenfassung Die Nachbehandlung der Knochenbrüche richtet sich nach dem Reizbedürfnis und den Durchstr?mungsverh?ltnissen. Am Beispiele des Speichenbruches wird gezeigt, da\ kritikloses Anwenden von Hei\luft, Massieren, Bewegen undZander technik nur Verschlimmerung bringt. Die Nebensch?digungen beim Speichenbruch (Bandschaden, Ganglien, Meniskussperre, traumatisches ?dem, arterielle Ern?hrungsst?rung) verlangen Sonderma\nahmen.

---

---

Nach einem Vortrage in der Münchener Chirurgenvereinigung, 31. 1. 33.     

Besprechungen

Ohne Zusammenfassung     

Monitoring of serologic immune parameters in inflammatory skin diseases

This paper deals with the correlation of clinical scoring and serologic markers of inflammation in atopic dermatitis and psoriasis. Serum eosinophil cationic protein (ECP), soluble inlerleukin-2 receptor (sIL-2R), total serum IgE, IgG and IgM anti-IgE antibodies, and IgE immune complexes were evaluated in monitoring inflammatory skin diseases such as atopic dermatitis and psoriasis. Well-established clinical activity scores were used as standards in recording skin improvement under treatment in a clinical setting. Serum ECP was found to be increased in both atopic dermatitis and psoriasis patients compared to normal controls; sIL-2R and IgE immune complexes were increased only in atopies with increased serum IgE. Anti-IgE antibodies did not show any deviation in both groups of patients. There was a significant elevation of sIL-2R and IgE immune complexes and a nonsignificant elevation of ECP in high-IgE atopics in comparison to those with normal serum IgE. In both groups of patients, there was a significant reduction of ECP and sIL-2R accompanying the improving skin condition. Serum IgE and the other immune parameters failed to respond. In contrast to other studies, serum ECP failed to correspond significantly with disease activity in our study. Our results showed measurable changes of ECP and sIL-2R for atopic dermatitis and/or psoriasis under treatment, but comparison to clinical scores remains difficult due to the different basis of the two systems. The only significant correlation was established for relative changes in sIL-2R and psoriasis area and intensity (PASI), a correlation which might be a useful approach in psoriasis.     

High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland

HIV-1 subtypes were determined in newly diagnosed residents of Switzerland. Blood was anonymously collected from patients with a first confirmed positive HIV-1 test result. Viral DNA from the env V3-V5 region was amplified by nested polymerase chain reaction (PCR) and screened for subtype B by heteroduplex mobility assay. All amplicons not identified as B were sequenced. From November 1996 to February 1998, 206 samples were analyzed. Main transmission risks were unprotected heterosexual (55.7%) or homosexual (27.1%) sexual contact or intravenous drug use (12.9%). Subtype B dominated in patients of Swiss, other European, American, or Asian citizenship; particularly high frequencies were found in homosexuals (97%) and drug users (94%). Non-B subtypes including A, C, D, E, F, G, H, a possible B/F recombinant, and a sequence related to J were present in 28.2% (95% confidence interval [CI], 22.9%-35.0%). Non-B were frequent in African citizens (95%), heterosexually infected individuals (44%), and women (43%). Heterosexually infected Swiss males harbored non-B strains in 18% and females in 33%. The results document a change in the epidemiology of newly diagnosed HIV-1 infections in Switzerland: predominance of heterosexual transmission and a high frequency of non-B subtypes.