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排序方式: 共有872条查询结果,搜索用时 23 毫秒
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100份大肠癌组织,用RT-PCR-SSCP检测P53基因CDNA突变;PAb1801单抗免疫组化检测P53基因蛋白搞表达并对大肠癌术对后病人作5年生存随访,比较上述2结果与大肠癌预后的关系,100例大肠癌中,RT-PCR-SSCP显示51例大肠癌P53基因CDNA突变,PAb1801阳性率62%,P53基因CDNA突变和P53基因蛋白高表达与Dukes分期无关,P53基因CDNA突变与P53基因 相似文献
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VAN HENDE C. DEN; LlSTER D.; MUYLLE E. DR. VET.ME; OOMS L. DR.SC; OYAERT W. PROF.DR.VE 《British journal of anaesthesia》1976,48(9):821-829
Thirteen of 31 Belgian Landrace pigs developed malignant hyperthermia(MH) after breathing halothane. A short period of exercise 1h before the administration of the triggering agent increasedthe incidence of the syndrome to 100% in eight similar pigs.Clinical symptoms were more marked and developed more rapidlyin the exercised pigs. All the reacting pigs became typicallyacidotic, developed rigor and died. Serum Na+, K+, Ca2+, c.p.k.,l.d.h. and protein concentrations were increased to a variableextent during the reaction and there was an increase in p.c.v.also. No hyper-glycaemia was detected in pigs which were restedbefore receiving halothane. Four of the eight exercised pigsbecame markedly hyperglycaemic and plasma noradrenaline increasedto higher values. Phosphocreatine and ATP decreased to low valuesand lactate increased in the muscles of all pigs which reacted.At the time of death, muscle glycogen had decreased significantlyin the rested, but not in the exercised, MH pigs.
*Present address: ARC Meat Research Institute, Langford, BristolBS18 7DY. 相似文献
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End-stage periventricular leukomalacia: MR evaluation 总被引:3,自引:0,他引:3
A prospective study was performed to assess the capabilities of magnetic resonance (MR) imaging in evaluation of end-stage periventricular leukomalacia (PVL) in six children, aged 31-54 months, in whom PVL had been documented by neurologic ultrasonography during the neonatal period. Eight children of similar age (four premature infants and four full-term infants) with normal neurologic development served as controls. A characteristic triad of PVL abnormalities was seen on MR images: (a) abnormally increased periventricular white-matter signal intensity on the first and second echo images of a T2-weighted sequence (repetition time = 2,000-2,400 msec, echo times = 20 or 30 and 80 msec), most commonly observed in the trigone regions of the lateral ventricles bilaterally; (b) marked loss of periventricular white matter in these regions of abnormal signal intensity, predominantly in the periatrial regions; and (c) compensatory focal ventricular enlargement adjacent to regions of abnormal signal intensity. In patients with the classic periatrial distribution of PVL lesions, general correlation between the degree of neurologic impairment and the severity of MR abnormalities was demonstrated. MR imaging was useful in detecting subtle forms of PVL in cases in which neurologic damage was subclinical. 相似文献
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Frostbite: experimental assessment of tissue damage using Tc-99m pyrophosphate. Work in progress 总被引:1,自引:0,他引:1
We designed an experimental model using a new method of freezing to study the pathogenesis and treatment of frostbite. Frostbite was simulated in a manner that closely resembles that which occurs in a natural environment. We used a radionuclide imaging technique to monitor the evolution and extent of tissue damage relative to temperature, rate of freezing, and controlled rewarming. Characteristic sequential changes were demonstrated on sequential nuclear scans. Nonperfusion, followed by perfusion, and finally again by nonperfusion occurred in all areas in which necrosis developed. The reappearance of nonperfusion corresponded to vascular injury and thrombosis evidenced at pathologic examination. We determined that lack of tissue perfusion corresponded to tissue injury. We believe that our experimental model provides an effective means of evaluating potential therapeutic regimens. 相似文献
130.
Carotid back pressures in conjunction with cerebral angiography 总被引:1,自引:0,他引:1