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Dimitrios-Anestis D. Moutzouris Paraskevi V. Kitsiou Argiris A. Talamagas Garyfallia I. Drossopoulou Theodore I. Kassimatis Nikolaos K. Katsilambros 《Renal failure》2013,35(3):353-358
Introduction. GLUTs are specific membrane proteins that transport glucose down a concentration gradient. There have been few studies on their expression in the kidney. The aim of this study was to identify the expression of GLUTs 1, 3, and 4 in HGEC and their regulation under diabetic milieu. Material and Methods. An immortalized cell line of HGEC was used. Cells were cultured in medium containing 5 or 25 mM D-glucose. Western blotting and flow cytometry were used to examine the presence of GLUTs (1, 3, 4) and alterations in expression. Results. Western blotting analysis revealed that GLUT-1 levels were increased by 53% in HGEC cultured under experimental diabetes compared to cells grown in 5mM glucose. GLUT-3 levels were also increased by 15% under diabetic conditions. GLUT-4 levels were decreased by 20% in diabetes. Fluorescence Activated Cell Sorting (FACS) analysis demonstrated that cell surface expression of GLUT-1 was increased by 28% in cells grown in 25mM glucose. High glucose concentration did not affect cell surface expression of GLUT-3 and GLUT-4. Discussion. These findings suggest that depressed GLUT4 expression in glomerulus and overexpression of GLUT-1 and in a lesser extent of GLUT-3 may alter the glucose uptake in these cells. It has been suggested that the overexpression of GLUT-1 in glomerulus, being the major isoform, may lead to the initial pathologic hallmarks of diabetic nephropathy. 相似文献
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Garyfallia Poulakou Georgios Renieris Labros Sabrakos Olympia Zarkotou Katherine Themeli-Digalaki Efstathia Perivolioti Eleni Kraniotaki Evangelos J. Giamarellos-Bourboulis Nikolaos Zavras 《International journal of antimicrobial agents》2019,53(2):190-194
The emergence of Acinetobacter baumannii with resistance to colistin (ABRC) led to the investigation of daptomycin as an adjunctive to colistin for these isolates. In this study, one ABRC carbapenemase-producing bloodstream isolate was examined. Minimum inhibitory concentrations (MICs) were >512, >512 and 8 µg/mL for imipenem, daptomycin and colistin, respectively. First, a ‘humanised’ model of the pharmacokinetics of daptomycin and colistin was developed in 18 male C57BL/6 mice. Then, 112 mice were infected by intraperitoneal injection of the ABRC isolate and were randomly assigned into four groups of once-daily treatment for 7 days: group A, controls treated with saline; group B, treated with 20 mg/kg colistin; group C, treated with 50 mg/kg daptomycin; and group D, treated with both agents. Survival was recorded for 7 days in ten mice per group. The remaining mice were sacrificed at regular time intervals following bacterial challenge and the bacterial outgrowth in the liver, lung and right kidney was determined. Mean serum concentrations of daptomycin at 15, 30 and 60 min post-dose were 121.8, 110.3 and 100.4 µg/mL, respectively. The respective concentrations of colistin were 13.9, 9.1 and 7.5 µg/mL. The 7-day mortality in groups A, B, C and D was 100%, 50%, 100% and 0%, respectively. Tissue outgrowth of the right kidney was significantly decreased in group D compared with group B after 72 h. Daptomycin used in combination with colistin leads to prolonged survival in an experimental infection by ABRC. Failure of colistin alone is probably related to rebound of tissue outgrowth. 相似文献
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Konstantinidou A Anninos H Spanakis N Kotsiakis X Syridou G Tsakris A Patsouris E 《Journal of medical virology》2007,79(6):754-757
Coxsackievirus intrauterine infection has been documented mostly on the basis of indirect evidence of transplacental transmission, with neonatal manifestations ranging from asymptomatic infection to meningoencephalitis, myocarditis, and generalized sepsis. This is the first report of prenatal findings and fetoplacental pathology in a third trimester fetus with coxsackie B3 transplacental infection confirmed by molecular techniques. Prenatal ultrasound detected severe reduction of fetal movements at the 27th week. Late onset fetal akinesia deformation sequence with mild arthrogryposis, necrotic meningoencephalitis with vascular calcifications, interstitial pneumonitis, mild myocardial hypertrophy, and chronic monocytic placental villitis were the cardinal findings at fetal autopsy following interruption of the pregnancy. 相似文献
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Nikolaos J. Tsagarakis Nektaria A. Kentrou Konstantinos A. Papadimitriou Maria Pagoni Garyfallia Kokkini Helen Papadaki Vassiliki Pappa Theodoros Marinakis Nikolaos I. Anagnostopoulos Chrissanthi Vadikolia Achilleas Anagnostopoulos Maria K. Angelopoulou Evangelos Terpos Christos Poziopoulos Konstantinos Anargyrou Dimitra Rontogianni Theodora Papadaki Aikaterini Psarra Flora N. Kontopidou Dimitra Skoumi Georgios Paterakis 《Leukemia research》2010,34(4):438-446
We present a cohort of 22 patients with type 2 dendritic cell (DC2) acute leukemia (or blastic plasmacytoid dendritic cell neoplasm-BPDCN, as it has been recently named), diagnosed in Greece over the past 12-year period, according to the main clinical and immunophenotypic features of this entity. Four additional cases are discussed, classified as leukemia of ambiguous lineage (LAL), because of the simultaneous detection of a CD56 negative DC2 population and of a second myeloid precursor cell population. The morphological features and cytogenetic findings of the typical BPDCN cases were similar to those previously described. Acute lymphoblastic leukemia-type chemotherapeutic regimens were more efficient in controlling the disease. Immunophenotyping of typical BPDCN cases revealed CD4+, CD56+, HLA-DR+ and CD123bright neoplastic cells, in the absence of major B-, T- and myeloid-associated markers, while the phenotype of the four cases characterized as LAL highlights the risk of misdiagnosis. Based on our experience, we propose a flow cytometric algorithmic approach for the distinction of typical BPDCN from certain types of acute myeloid leukemia, but also for the identification of acute myeloid leukemia, admixed with CD56 negative DC2 cells, which could be misdiagnosed as BPDCN. 相似文献
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Vassilakopoulos TP Angelopoulou MK Siakantaris MP Konstantinou N Symeonidis A Karmiris T Repoussis P Roussou P Dimopoulos AM Kokoris SI Dimitriadou EM Kyrtsonis MC Dimopoulou MN Tsatalas C Kokkinis G Vrakidou E Grigoraki V Poziopoulos C Stamatellou M Liapis D Georgiou G Panayiotidis P Pangalis GA;Hellenic Cooperative Lymphoma Group 《Haematologica》2006,91(1):32-39