20-year monitoring of acute cardiovascular diseases in population of large industrial city in West Siberia (epidemiological study)

AIM: To reveal trends in incidence rates of acute cardiovascular diseases (ACD) in a large industrial city of the West Siberia. MATERIALS AND METHODS: Studies on WHO programs "Acute Myocardial Infarction Register" and "MONICA" have been performed in three districts of Novosibirsk. The diagnostic categories were detected without difference. The observation covered stable population of 500,000 residents aged 25-64 years. Trends in the myocardial infarction (MI) mortality, morbidity and lethality were analysed for 1977-1996. RESULTS: The above trends were stable except for 1986 when MI mortality, morbidity and lethality decreased and 1988 and 1994 when they went up. The reduction was due to 7-year prevention program while the rise was consequent to discontinuation of the preventive measures. Major risk factors of ischemic heart disease, according to screenings conducted in 1984, 1988 and 1994 remained at about the same level. Social stress closely correlates with a rise in MI morbidity and mortality. The latter in 1994 grew owing to higher rates of MI mortality and morbidity among the oldest men and females of different age groups. CONCLUSION: Urgent intensification of prophylactic measures is needed both at the populational level and the level of high risk strategy.     

Results of the one-stage screening for ischemic heart disease in the Tumen population sample

AIM: To study prevalence of ischemic heart disease (IHD) in free living population of Tumen. MATERIAL AND METHODS: A one-stage cardiological screening covered 1608 Tumen residents (70.3% of the respondents of the mail questionnaire survey). IHD was stated by the standard methods. RESULTS: IHD incidence among male and female population of Tumen was rather high. Angina of effort was found in 4.5% of males and 5.1% of females, painless IHD was detected in 3.2 and 3.7% of male and female 55-64-year-old population, respectively, by extended criteria. IHD incidence rate by the extended criteria reached 12.5%. CONCLUSION: Primary results of the survey indicate that Tumen population is at high risk of cardiovascular diseases. This fact requires a detailed analysis of the trends in IHD prevalence in a prospective study.     

bcl～Xs基因转移联合顺氯氨铂对卵巢癌细胞生长作用的研究

目的 采用以复制缺陷型腺病毒为载体的ｂｃｌ－Ｘｓ基因（Ａｄｖ－ｂｃｌ－Ｘｓ）对卵巢癌细胞进行基因转移,同时使用顺氯氨铂,观察其对卵巢癌细胞生长的抑制作用,方法 用不同浓度的Ａｄｖ－ｂｃｌ－Ｘｓ感染卵巢癌细胞株ＮｕＴｕ－１９,同时使用顺氯氨铂,３ｄ后,用四甲基偶氮唑蓝比色法检测存活细胞,并用流式细胞仪计数细胞周期百分比。结果 Ａｄｖ－ｂｃｌ－Ｘｓ对卵巢癌细胞生长的抑制作用随病毒浓度的增加而增大,至浓     

Arteriovenous fistula of the internal maxillary artery: treatment with transarterial embolization

Six patients with arteriovenous fistulas of the internal maxillary artery were treated with transarterial embolization. The patients ranged in age from 19 to 47 years, with a mean of 26.5 years. Each had a lifelong history of symptoms suggestive of a congenital origin of symptoms. There was no history of trauma. The most common initial symptoms were bruit (83%), pulsatile mass (67%), and pain (50%). In one patient prior surgical ligation of the external carotid artery had been attempted, but it led to aggravation of headaches. All patients were treated with placement of a detachable balloon at the fistula site. In one patient the balloon migrated through the fistula, which was retreated with coils. Complete obliteration of the fistula was achieved in all patients. The follow-up ranged from 2 months to 10 years, with a mean of 5.2 years. Congenital arteriovenous fistulas of the internal maxillary artery are rare and can be treated effectively with transvascular techniques.     

Dural fistulas involving the transverse and sigmoid sinuses: results of treatment in 28 patients

Twenty-eight symptomatic dural fistulas involving the transverse and sigmoid sinuses were treated between 1978 and 1986 with a variety of treatment modalities. Occipital artery compression therapy resulted in a complete cure in two of nine patients (22%) and improvement in three of nine (33%). There were no complications from this treatment. Patients who were excluded or in whom compression therapy failed were treated with embolization alone or in conjunction with surgery. Of the 17 patients who underwent embolization alone, ten were cured and six were improved. Six patients had a combination of embolization and surgery; four patients were cured and two improved. There were three complications in this series, one related to surgery and two related to embolization.