全文获取类型
收费全文 | 262篇 |
免费 | 10篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 9篇 |
妇产科学 | 5篇 |
基础医学 | 15篇 |
口腔科学 | 7篇 |
临床医学 | 44篇 |
内科学 | 72篇 |
皮肤病学 | 6篇 |
神经病学 | 10篇 |
特种医学 | 67篇 |
外科学 | 19篇 |
综合类 | 19篇 |
预防医学 | 7篇 |
眼科学 | 1篇 |
药学 | 18篇 |
肿瘤学 | 8篇 |
出版年
2020年 | 1篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 4篇 |
2014年 | 6篇 |
2013年 | 4篇 |
2012年 | 4篇 |
2011年 | 5篇 |
2010年 | 13篇 |
2009年 | 13篇 |
2008年 | 6篇 |
2007年 | 28篇 |
2006年 | 3篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 18篇 |
1997年 | 14篇 |
1996年 | 17篇 |
1995年 | 8篇 |
1994年 | 14篇 |
1993年 | 20篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 6篇 |
1980年 | 11篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1968年 | 1篇 |
1959年 | 3篇 |
1958年 | 1篇 |
1957年 | 3篇 |
1956年 | 4篇 |
1954年 | 8篇 |
1949年 | 3篇 |
1948年 | 4篇 |
1946年 | 1篇 |
排序方式: 共有308条查询结果,搜索用时 180 毫秒
91.
92.
93.
异丙酚复合氯胺酮全麻诱导对血流动力学的影响 总被引:3,自引:2,他引:1
0 引言 我们观察氯胺酮对异丙酚静脉复合诱导时血流动力学的影响 ,并以芬太尼复合异丙酚全麻诱导做对照研究 .1 对象和方法1.1 对象 30例 ASA ~ 级择期行全麻手术的患者 .男2 0例 ,女 10例 ,年龄 18~ 5 5岁 ,体质量 49~ 75 kg,随机分为两组 ,A组为异丙酚复合氯胺酮组 ,B组为异丙酚复合芬太尼组 ,每组 15例 .1.2 方法 术前 30 min im苯巴比妥钠 0 .1g,阿托品 0 .5mg. A组诱导为 iv异丙酚 2 mg· kg- 1 ,氯胺酮 1mg· kg- 1及维库溴胺 0 .1mg· kg- 1 . B组为 iv异丙酚 2 m g· kg- 1 ,芬太尼 2 μg· kg- 1 及维库溴胺 0 .1mg… 相似文献
94.
Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC) 总被引:1,自引:1,他引:1
Kelsell DP; Risk JM; Leigh IM; Stevens HP; Ellis A; Hennies HC; Reis A; Weissenbach J; Bishop DT; Spurr NK; Field JK 《Human molecular genetics》1996,5(6):857-860
Focal non-epidermolytic palmoplantar keratoderma (PPK or palmoplantar
ectodermal dysplasia type III) is associated with oesophageal cancer in
three families: two large pedigrees located in Liverpool, UK and in the
midwestern American states and one smaller family from Germany. In these
families, the PPK is inherited as autosomal dominant and has a late onset,
usually manifesting between 7 and 8 years of age. The disease is
characterised by thickening of the pressure areas of the soles, but is not
restricted to the feet and also presents with oral leukokeratosis and
follicular hyperkeratosis. The disease locus [previously termed the
"tylosis oesophageal cancer gene' (TOC) locus] has been mapped to
17q23-qter by linkage analysis. This region is located telomeric to the
keratin 16 gene, in which mutations have been identified in focal PPK
families who show no increased cancer risk. We describe the close mapping
of this locus to the interval between AFMb054zf9 and D17S1603 using
haplotype analysis of additional Genethon markers in the region and show
that although the American family is unlikely to be related to either of
the other two, the UK and German pedigrees may share a common descent. This
work provides a basis for positional cloning and candidate gene analysis in
order to identify a gene that may be involved in familial oesophageal
cancer.
相似文献
95.
Acoustic neuromas: Gd-DTPA enhancement in MR imaging 总被引:1,自引:0,他引:1
Magnetic resonance (MR) imaging examinations were performed in ten patients with 12 acoustic neuromas before and after intravenous administration of 0.1 mmol/kg body weight gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). The degree of enhancement was greatest with the inversion recovery sequence 1,500/500/44 (repetition time [TR]/inversion time/echo delay time [TE]), followed by spin-echo (SE) 544/44 (TR/TE) sequences, then by SE 1,500/44 and SE 1,500/80 sequences. After enhancement there was a 50% reduction for measured T1 values, 33% for T2, and no significant change for proton density. There were no toxic effects on patients. Enhanced CT scans failed to demonstrate lesions in six of 12 cases. Air-CT technique improved sensitivity in four of five cases. Enhanced MR imaging added significant clinical information in two small intracanalicular tumors and in one recurrent tumor. 相似文献
96.
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro 总被引:9,自引:1,他引:8
Kizaki M; Dawson MI; Heyman R; Elster E; Morosetti R; Pakkala S; Chen DL; Ueno H; Chao W; Morikawa M; Ikeda Y; Heber D; Pfahl M; Koeffler HP 《Blood》1996,87(5):1977-1984
97.
A digital imaging system that employs a novel scanning x-ray tube, a multiple-slit assembly (MSA), and an image intensifier (II)-TV digital system is described. Use of the MSA can increase x-ray utilization by a factor of 100 over that obtained with single-slit systems. Scatter and veiling glare can be reduced substantially by synthesizing the final image from a number of multiple-slit images, resulting in improvement in contrast sensitivity. An experimental prototype system consisted of a conventional x-ray tube and an II-TV digital system used in conjunction with mechanical scanning of the MSA. Attenuation curves measured with an aluminum stepwedge showed that scatter and veiling glare were eliminated by this approach. Reconstructed images of phantoms were superior to images obtained with conventional wide-beam exposure. Physical parameters related to design of the scanning x-ray tube and a digital system for acquiring images of the chest are discussed. 相似文献
98.
Blood pressure independent effects of nitrendipine on cardiac structure in patients after renal transplantation 总被引:2,自引:2,他引:0
Rockstroh JK; Schobel HP; Vogt-Ladner G; Hauser I; Neumayer HH; Schmieder RE 《Nephrology, dialysis, transplantation》1997,12(7):1441-1447
Left ventricular hypertrophy is well established as a blood pressure
independent cardiovascular risk factor in patients on renal replacement
therapy. The effects of antihypertensive treatment on myocardial structure
and function in renal transplant recipients have been so far only rarely
investigated. In a double-blind, placebo-controlled study patients were
randomized to the calcium channel blocker nitrendipine or placebo if the
transplanted kidney had developed a stable phase. Normotensive patients
received nitrendipine 2 x 5 mg daily or placebo, hypertensive patients
received 2 x 10 mg up to 2 x 20 mg nitrendipine daily or placebo. To
achieve adequate blood pressure control, all patients with still elevated
blood pressure on study medication received antihypertensive drugs other
than calcium channels blockers. Ambulatory blood pressure recording and
2D-guided M-mode echocardiography were performed at baseline and upon
completion of the study. In addition, laboratory workup (including serum
creatinine and lipids) was done, and serum aldosterone, plasma renin
activity, plasma angiotensin II and blood glucose levels were measured in
all patients at baseline and after at least 12 months of therapy.
Ambulatory blood pressure was almost identical between both groups at study
baseline and follow-up. In renal transplant patients on nitrendipine,
posterior wall thickness (-0.10 +/- 1.77 mm) and septal wall thickness
(-0.83 +/- 2.23 mm) did not change significantly from baseline. In
contrast, posterior wall thickness (0.71 +/- 0.92 mm, P < 0.01) and
septal wall thickness (0.97 +/- 2.20 mm, P < 0.05) increased in patients
on placebo, which differed from the observed changes on nitrendipine
(ANOVA: P = 0.093 and P = 0.048, respectively). Relative wall thickness, a
parameter for concentric left ventricular hypertrophy, became numerically
smaller on nitrendipine therapy from 0.46 +/- 0.07 to 0.44 +/- 0.09 (-0.02
+/- 0.09, NS) but increased from 0.42 +/- 0.08 to 0.48 +/- 0.08 in the
placebo arm (+0.04 +/- 0.08, P < 0.02), which was also significant
between the two groups (ANOVA: P = 0.036). Endocrine parameters, lipids and
blood glucose were not different between the two groups. We conclude from
these data that the calcium channel blocker nitrendipine exerted beneficial
effects on cardiac structure in patients after renal transplantation
independent of blood pressure.
相似文献
99.
100.