Hypoparathyroidism simulating brain tumor—an unusual presentation

A 13 yr old boy presented with generalised tonic-clonic convulsions and papilledema simulating an intracranial space occupying lesion. CT scan showed bilateral basal ganglia calcification. Biochemical investigations established the diagnosis of hypoparathyroidism. On treatment with oral calcium and vitamin D the patients became seizure free and papilledema regressed. The possibility of hypoparathyroidism should be considered when basal ganglia calcification is seen and CT scan.     

Prevalence of multiple drug resistance amongst strains of Esch.coli isolated from cases of diarrhea

A total of 348 Esch.coli strains isolated from cases of diarrhoea in infants and children during 1979 and received at the National Salmonella and Escherichia Centre, Central Research Institute, Kasauli were serotyped and tested for the prevalence of multiple drug resistance. These strains belonged to 43 different serotypes, the most common being 060, 01, 011, 017 and 020. About one third (113) of the strains could not be typed. It was found that 248 strains (80.5%) were resistant to 3 or more drugs. The resistance pattern of various serotvpes and their epidemiohgical significance with particular reference to diarrhea in children isdiscussedln this report.     

Macular infarction after transpupillary thermotherapy for subfoveal choroidal neovascularization in age-related macular degeneration

PURPOSE: To report the complication of macular infarction after transpupillary thermotherapy (TTT) for the treatment of subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). DESIGN: Interventional case reports. METHODS: Among 107 consecutive patients with subfoveal CNV due to AMD, a 73-year-old woman with recurrent subfoveal classic choroidal neovascularization and a 76-year-old man with subfoveal occult choroidal neovascularization with adjacent areas of geographic retinal pigment epithelium atrophy noted a severe decrease in visual acuity and photopsias within hours of undergoing TTT. RESULTS: Both patients had marked whitening of the macula clinically and closure of the perifoveal capillaries on fluorescein angiography. Immediately after treatment their visual acuity decreased from 20/200 to 6/200 and from 20/400 to 2/200, respectively. Several months later, all exudation had resolved and their visual acuity had stabilized at 20/100 and 20/200, respectively. CONCLUSIONS: Macular infarction is a rare complication that occurred in two of 107 patients undergoing TTT for subfoveal CNV due to AMD. The presence of geographic retinal pigment epithelium atrophy or a previous laser treatment scar in the macular region may predispose patients to this complication.     

HIVAN and medication use in chronic dialysis patients in the United States: analysis of the USRDS DMMS Wave 2 study

Background  

The use and possible effects of factors known to improve outcomes in patients with human immunodeficiency virus associated nephropathy (HIVAN), namely of angiotensin converting enzyme inhibitors (ACE) and antiretroviral therapy, has not been reported for a national sample of dialysis patients.     

The Mennen femoral plate for fixation of periprosthetic femoral fractures following hip arthroplasty

Periprosthetic fractures can be treated by various methods. The Mennen femoral plate used to be a common implant in our region to stabilise periprosthetic femoral fractures following hip arthroplasty. This device has been used in 16 patients in our region from three different centres. The periprosthetic femoral fractures occurred approximately 7 years after the hip arthroplasty procedure. After stabilisation of the fracture, patients were kept non-weight bearing. Weight bearing was commenced once there was clinical and radiological evidence of fracture union. About 75% of our patients had a complication following fixation of the fracture. In all of these patients the main complication was varus mal-union of the fracture. As per our study the Mennen femoral plate seems to be a weak fixation device. The plate is unable to counter the medial compressive forces on the femur leading to a varus collapse of the fracture.     

Antibiotic associated diarrhoea: a controlled study comparing plain antibiotic with those containing protected lactobacilli

Antibiotic associated diarrhoea is known to occur with broad spectrum antibiotics. Lactobacillus has been used for prophylaxis and therapy of this condition. In a double blind controlled study, the antibiotic containing ampicillin (250 mg) and cloxacillin (250 mg) with or without protected lactobacilli was evaluated in 740 patients undergoing cataract surgery. The incidence of diarrhoea in patients receiving plain antibiotic was 13.3% compared to 0.0% in patients receiving antibiotic with protected lactobacilli (p<0.001). The study demonstrates that antibiotic formulations containing protected lactobacilli maintain prophylactic effect of lactobacilli.     

Second branchial cleft cysts: variability of sonographic appearances in adult cases

BACKGROUND AND PURPOSE: Previous reports have suggested that second branchial cleft cysts (BCCs) appear on sonograms as well-defined, cystic masses with thin walls and posterior enhancement. Previous CT and MR imaging findings, however, have indicated heterogeneity of these masses, and, in our experience, sonography also shows a similar variable appearance. In this communication, we report the cases of 17 patients with second BCCs and document the variability of sonographic patterns. METHODS: The sonograms of 17 adults with second BCCs were reviewed. Only patients with surgical or cytologic evidence of BCCs were included in this study. The features evaluated were the location, internal echogenicity, posterior enhancement, and presence of septa and fistulous tract. RESULTS: Four patterns of second BCCs were identified: anechoic (41%), homogeneously hypoechoic with internal debris (23.5%), pseudosolid (12%), and heterogeneous (23.5%). The majority (70%) showed posterior enhancement. All were situated in their classical location, posterior to the submandibular gland, superficial to the carotid artery and internal jugular vein, and closely related to the medial and anterior margin of the sternomastoid muscle. Fourteen (82%) of the 17 BCCs had imperceptible walls, and all were well defined. For none of the patients was a fistulous tract revealed by sonography; the presence of internal septations was revealed for three patients. CONCLUSION: As previously suggested by CT and MR imaging findings, sonography reinforces that second BCCs in adults are not simple cysts but have a complex sonographic pattern ranging from a typical anechoic to a pseudosolid appearance.     

Dysgerminoma of the ovary: A retrospective study

A retrospective analysis of 22 patients with ovarian dysgerminoma who were treated between 1980 and 1987 was carried out. The median age at presentation was 24.5 years. A total of 15 patients were in stage I, one patient was in stage II and six patients were in stage III. Bilateral ovarian involvement was present in four patients. Conservative surgery was carried out in nine patients and 11 patients underwent radical surgery. Two patients had biopsy only. Fourteen patients received adjuvant radiotherapy and three patients received salvage radiation for recurrent disease. The 10-year actuarial survival rate was 81.8%. All 15 patients in stage I were alive and disease-free at a median follow-up of 125 months. Four patients (one in stage II and three in stage III) died of progressive or recurrent abdominopelvic disease. Pelvic recurrence occurred after conservative surgery in two patients in stage IA who had a tumour size greater than 10 cm, but they were salvaged with radical surgery, chemotherapy and radiotherapy. There were seven patients aged 20 years or less. All were alive and disease-free at a median follow-up of 127 months.