The subdivisions of the intermediolateral nucleus in the sacral spinal cord of the cat

The subdivisions of the sacral intermediolateral nucleus (IML) of the cat have been studied by using a double-labeling technique of retrograde Fluoro-gold (FG) and wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) tracing. The parasympathetic preganglionic neurons (PGNs) that were labeled by the FG injected into the pelvic nerve formed a ‘V’-shaped column known as the sacral parasympathetic nucleus (SPN) in the sacral IML. The neurons that were labeled by the WGA-HRP applied to the lateral parabrachial nucleus (PBL) formed an elongated spindle-shaped column extending throughout the IML of the sacral segments. We designated it by the name of sacral visceral sensory nucleus (SVSN). These findings indicate that the sacral IML of the cat contain two distinct subdivisions, SPN and SVSN.     

芬太尼／哌替啶致Oddi括约肌痉挛的探讨

２００例择期胆囊切除＋术中胆道造影患者分二组；芬太尼１７ｕｇ／ｋｇ静注（Ｆ组，ｎ＝１００）、哌替啶１ｍｇ／ｋｇ静注。评价两种麻醉性镇痛药致Ｏｄｄｉ括约肌痉挛的发生率，结果：８例病人造影剂不能通过Ｏｄｄｉ括约肌、十二指肠不显影，胆总管下端显示“鸟嘴样”或“假结石”影像，后者３例病人胆总管探查阴性，静注纳络酮０．４ｍｇ后，全部病例造影剂顺利进入十二指肠。结论：硬膜外麻醉辅用小剂量芬太尼／哌替啶时Ｏｄｄ     

Alterations of G-protein Coupling Function in Phosphoinositide Signalling Pathways of Rat Hippocampus by Ischaemic Brain Injury

The activation of membrane-associated phospholipase C is rapidly and transiently induced in the central nervous system by a variety of stimuli. Ischaemic brain injury is one of the situations that leads to a dramatic increase in polyphosphoinositide (PPI) turnover. In this study, stimulation of PPI hydrolysis by glutamate (500 μM) was measured in hippocampal slices from rats up to 21 days after an ischaemic insult of 30 min. Ischaemia was induced using the four-vessel occlusion method. PPI hydrolysis elicited by glutamate was significantly increased in the slices prepared from ischaemic rats 24 h after reperfusion, the accumulation of inositol phosphates (InsP_s) and inositol 1,4,5-trisphosphate (InsP₃) was 614±74% ( n = 8) and 182±11% ( n = 9) of the basal level respectively. This potentiation was also observed 21 days after ischaemia. Hyper-responsiveness to glutamate was also accompanied by an increase in AIF⁻₄-stimulated formation of [³H]inositol phosphates. In addition, global ischaemia did not change either high-affinity [³H]glutamate binding in hippocampal membranes or the stimulation of PPI hydrolysis by carbachol or noradrenaline in hippocampal slices. The present results suggest that the increased responsiveness to glutamate is the result, at least in part, of functional changes at the G-protein level, and may contribute to the pathophysiology of ischaemic brain injury or to the regenerative phenomena that accompany ischaemic damage.     

大同市103例高龄老人营养情况及心理状况调查

本文对103名高龄老人进行营养情况调查、心理状况调查和体测量,结果表明:高龄老人体质指数大于26者很少,只要老龄人的各种营养素达到供给量标准,心理状态乐观满意,且不吸烟不酗酒者,则可长命百岁。     

Detection of circulating antigen by McAb-AST for evaluating the efficacy of anti-Leishmania chemotherapy.

We have adapted the simple and sensitive McAb-antigen spot test (AST) for evaluating the efficacy of anti-Leishmania chemotherapy. Serum samples from 37 kala-azar patients were tested by McAb-AST, and all showed definite positive reactions before treatment. After a course of antimony treatment, 20 turned negative, coupled with the disappearance of clinical symptoms; another 12 cases responded with weak positivity accompanied by an improvement of clinical manifestations; and the remaining 5 antimony-resistant patients showed strong positive reactions, with their conditions gradually worsening. Furthermore, all 6 cases in which the diagnosis was missed by the bone marrow smear method turned McAb-AST negative after chemotherapy. These results suggest that McAb-AST can be used to evaluate the efficacy of chemotherapy as well as to avoid missed diagnosis by the bone marrow smear method.     

缺血性脑血管病患者的血脂水平

目的分析缺血性脑血管病（ICVD）患者的血脂水平，为今后预防保健及康复干预决策的制定提供依据。方法在佛山市第一人民医院病案数据库中检索1991-2004年诊断为ICVD的病例共2886例，其中2000-2004年ICVD患者共1430例为一亚组，以我院同时期保健科随机选取的400名健康体检人群为对照组，记录血脂情况，进行对照分析。结果血TC、TG和LDL—C水平ICVD患者组明显高于健康体检人群，差异有统计学意义。男女两性血脂水平均随年龄增加而逐渐增高，50岁以上女性血脂水平明显高于同龄组男性。血脂代谢异常患病率随着年代的推移呈逐步上升趋势，总胆固醇从1991—1994年的24．5％到2001-2004年的38．1％（男性）和22．3％到38．5％（女性），且明显高于国内2000-2001年普查人群高脂血症的患病率。结论佛山地区血脂异常是ICVD的重要原因之一。     

精神分裂症服用氯氮平能降低其甲状腺素水平的对照分析

目的探索氯氮平治疗是否影响T3、T4和TSH水平.方法对17例精神分裂症患者,给予氯氮平治疗第4天和第4周末分别测定T3、T4和TSH水平.结果治疗第4周末的T3(3.309±0.689)、T4(9.449±1.941)水平比第4天的T3(3.915±0.850)、T4(11.178±2.180)水平明显降低(P均＜0.05).结论氯氮平治疗能降低甲状腺素水平.     

老中青年急性心肌梗塞的临床特点及相关因素分析

急性心肌梗塞(acute myocardial infarction．AMI)是老年人常见的心血管疾病之一。但近年来，中青年AMI发病率有上升趋势，为了解各年龄段AMI的临床特点及其相关因素，现对某院近年来收住的AMI患者进行回顾性对比分析，现报告如下。     

Chronic Kidney Isograft and Allograft Rejection

In this study antigen-independent factor in the pathogenesis of chronic rejection of organ transplants was examined.Kidney isografts and allografts were transplanted orthotopically into bilaterally nephroectomized rat recipients and studied functionaaly,morphologically and immunohistologically,at serial intervals up to 52 weeks after transplantation.Allograft recipients developed progressive proteinuria after 12 weeks,with gradual renal failure ultimately leading to death.At the same time,morphological changes,including progressive arteriosclerosis and glomerulosclerosis ,tubular atrophy and interstitial fibrosis,developed.Immunohistologically,macrophages infiltrated glomeruli during this period and cytokines became unregulated.Our results showed that antigen-independent functional and morphological changes occurred in long-tern kidney isografts and mimicked those appearing much earlier in allografts that reject chronically.Initial injury and extent of functioning renal mass is suggested to be important factor for such late changes.