首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1320837篇
  免费   97906篇
  国内免费   2376篇
耳鼻咽喉   18969篇
儿科学   43146篇
妇产科学   38671篇
基础医学   194326篇
口腔科学   36048篇
临床医学   112430篇
内科学   260518篇
皮肤病学   28101篇
神经病学   103092篇
特种医学   52567篇
外国民族医学   366篇
外科学   202835篇
综合类   26926篇
现状与发展   2篇
一般理论   315篇
预防医学   95519篇
眼科学   30310篇
药学   101718篇
  1篇
中国医学   2912篇
肿瘤学   72347篇
  2018年   13044篇
  2016年   11484篇
  2015年   13466篇
  2014年   18188篇
  2013年   26923篇
  2012年   37181篇
  2011年   39439篇
  2010年   23385篇
  2009年   21810篇
  2008年   37457篇
  2007年   40414篇
  2006年   40696篇
  2005年   39852篇
  2004年   38127篇
  2003年   36932篇
  2002年   36358篇
  2001年   58830篇
  2000年   60296篇
  1999年   51298篇
  1998年   14538篇
  1997年   13088篇
  1996年   13305篇
  1995年   12573篇
  1994年   11954篇
  1993年   11067篇
  1992年   41410篇
  1991年   40824篇
  1990年   40301篇
  1989年   39163篇
  1988年   36538篇
  1987年   35791篇
  1986年   34111篇
  1985年   32520篇
  1984年   24230篇
  1983年   21079篇
  1982年   12581篇
  1981年   11114篇
  1979年   22875篇
  1978年   16082篇
  1977年   13881篇
  1976年   13102篇
  1975年   14327篇
  1974年   16842篇
  1973年   16243篇
  1972年   15448篇
  1971年   14317篇
  1970年   13322篇
  1969年   12835篇
  1968年   12076篇
  1967年   10551篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
63.
64.
BackgroundThe aim of this paper is to assess the current state of quality and outcomes measures being reported for hepatic resections in the recent literature.MethodsMedline and PubMed databases were searched for English language articles published between 1 January 2002 and 30 April 2013. Two examiners reviewed each article and relevant citations for appropriateness of inclusion, which excluded papers of liver donor hepatic resections, repeat hepatectomies or meta-analyses. Data were extracted and summarized by two examiners for analysis.ResultsFifty-five studies were identified with suitable reporting to assess peri-operative mortality in hepatic resections. In only 35% (19/55) of the studies was the follow-up time explicitly stated, and in 47% (26/55) of studies peri-operative mortality was limited to in-hospital or 30 days. The time period in which complications were captured was not explicitly stated in 19 out of 28 studies. The remaining studies only captured complications within 30 days of the index operation (8/28). There was a paucity of quality literature addressing truly patient-centred outcomes.ConclusionQuality outcomes after a hepatic resection are inconsistently reported in the literature. Quality outcome studies for a hepatectomy should report mortality and morbidity at a minimum of 90 days after surgery.  相似文献   
65.
66.
Alterations in autophagy are increasingly being recognized in the pathogenesis of proteinopathies like Alzheimer's disease (AD). This study was conducted to evaluate whether melatonin treatment could provide beneficial effects in an Alzheimer model related to tauopathy by improving the autophagic flux and, thereby, prevent cognitive decline. The injection of AAV‐hTauP301L viral vectors and treatment/injection with okadaic acid were used to achieve mouse and human ex vivo, and in vivo tau‐related models. Melatonin (10 μmol/L) impeded oxidative stress, tau hyperphosphorylation, and cell death by restoring autophagy flux in the ex vivo models. In the in vivo studies, intracerebroventricular injection of AAV‐hTauP301L increased oxidative stress, neuroinflammation, and tau hyperphosphorylation in the hippocampus 7 days after the injection, without inducing cognitive impairment; however, when animals were maintained for 28 days, cognitive decline was apparent. Interestingly, late melatonin treatment (10 mg/kg), starting once the alterations mentioned above were established (from day 7 to day 28), reduced oxidative stress, neuroinflammation, tau hyperphosphorylation, and caspase‐3 activation; these observations correlated with restoration of the autophagy flux and memory improvement. This study highlights the importance of autophagic dysregulation in tauopathy and how administration of pharmacological doses of melatonin, once tauopathy is initiated, can restore the autophagy flux, reduce proteinopathy, and prevent cognitive decline. We therefore propose exogenous melatonin supplementation or the development of melatonin derivatives to improve autophagy flux for the treatment of proteinopathies like AD.  相似文献   
67.
68.
69.
70.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号