首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1478904篇
  免费   102428篇
  国内免费   2467篇
耳鼻咽喉   20819篇
儿科学   48414篇
妇产科学   41925篇
基础医学   215919篇
口腔科学   40192篇
临床医学   124681篇
内科学   294891篇
皮肤病学   31855篇
神经病学   117410篇
特种医学   56041篇
外国民族医学   463篇
外科学   222145篇
综合类   28082篇
现状与发展   1篇
一般理论   359篇
预防医学   111101篇
眼科学   33185篇
药学   112080篇
  16篇
中国医学   3326篇
肿瘤学   80894篇
  2019年   11679篇
  2018年   18565篇
  2017年   13432篇
  2016年   14507篇
  2015年   16685篇
  2014年   21338篇
  2013年   32711篇
  2012年   48075篇
  2011年   50433篇
  2010年   28429篇
  2009年   25417篇
  2008年   47249篇
  2007年   51023篇
  2006年   50419篇
  2005年   49554篇
  2004年   47271篇
  2003年   45327篇
  2002年   44260篇
  2001年   62654篇
  2000年   64199篇
  1999年   54777篇
  1998年   15019篇
  1997年   13480篇
  1996年   13662篇
  1995年   12894篇
  1994年   12251篇
  1992年   43361篇
  1991年   42479篇
  1990年   41930篇
  1989年   40549篇
  1988年   37828篇
  1987年   36914篇
  1986年   35190篇
  1985年   33507篇
  1984年   24929篇
  1983年   21686篇
  1982年   12908篇
  1981年   11355篇
  1979年   23541篇
  1978年   16494篇
  1977年   14294篇
  1976年   13465篇
  1975年   14809篇
  1974年   17415篇
  1973年   16841篇
  1972年   16009篇
  1971年   14926篇
  1970年   13877篇
  1969年   13421篇
  1968年   12567篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.

Background

Since recent reports have shown that (-)-Epigallocatechin-3-gallate (EGCG) could be used for treating proliferative and inflammatory disorders, we explored its use for the management of corneal chemical burns.

Materials and methods

Initially, EGCG was assayed on the rabbit corneal epithelial cell line RCE1(5T5) to establish the best testing conditions, and to avoid unwanted outcomes in the experimental animals. Then, we studied its effects on cell proliferation, cell cycle progression and cell differentiation. Afterwards, we instilled EGCG in experimental grade II corneal alkali burns in mice, three times a day up to 21 days, and evaluated by slit lamp examination and histological sections of corneal epithelial, corneal endothelial and stromal edema, as well as the presence of inflammatory cells and neovascularization.

Results

EGCG reduced cell growth and led to a decline in the proportion of proliferative cells in a concentration dependent manner. At 10 μM, EGCG promoted cell differentiation, an effect not related with apoptosis or cytotoxicity. When 10 μM EGCG was instilled in corneal alkali burns in mice three times a day up to 21 days, EGCG significantly reduced corneal opacity and neovascularization. The improved clinical appearance of the cornea was associated to a controlled epithelial growth; epithelial morphology was similar to that observed in normal epithelium and contrasted with the hyperproliferative, desquamating epithelium observed in control burn wounds. EGCG reduced corneal, stromal and endothelial edema, and wound inflammation.

Conclusion

This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy.  相似文献   
23.
24.
25.
26.
27.
BackgroundThe aim of this paper is to assess the current state of quality and outcomes measures being reported for hepatic resections in the recent literature.MethodsMedline and PubMed databases were searched for English language articles published between 1 January 2002 and 30 April 2013. Two examiners reviewed each article and relevant citations for appropriateness of inclusion, which excluded papers of liver donor hepatic resections, repeat hepatectomies or meta-analyses. Data were extracted and summarized by two examiners for analysis.ResultsFifty-five studies were identified with suitable reporting to assess peri-operative mortality in hepatic resections. In only 35% (19/55) of the studies was the follow-up time explicitly stated, and in 47% (26/55) of studies peri-operative mortality was limited to in-hospital or 30 days. The time period in which complications were captured was not explicitly stated in 19 out of 28 studies. The remaining studies only captured complications within 30 days of the index operation (8/28). There was a paucity of quality literature addressing truly patient-centred outcomes.ConclusionQuality outcomes after a hepatic resection are inconsistently reported in the literature. Quality outcome studies for a hepatectomy should report mortality and morbidity at a minimum of 90 days after surgery.  相似文献   
28.
29.
30.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号