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61.
62.
Fumiaki Mori Kunikazu Tanji Yasuko Toyoshima Hidenao Sasaki Mari Yoshida Akiyoshi Kakita Hitoshi Takahashi Koichi Wakabayashi 《Neuropathology》2013,33(6):637-644
Valosin‐containing protein (VCP) is associated with multiple cellular functions, including ubiquitin‐dependent protein degradation. Mutations in VCP are known to cause inclusion body myopathy with Paget's disease and frontotemporal dementia and familial amyotrophic lateral sclerosis (fALS; ALS14), both of which are characterized by trans‐activation response DNA protein 43 (TDP‐43)‐positive neuronal cytoplasmic and nuclear inclusions. Recently, immunoreactivity for fALS‐associated proteins (TDP‐43, fused in sarcoma (FUS), optineurin and ubiquilin‐2) were reported to be present in cytoplasmic and nuclear inclusions in various neurodegenerative diseases. However, the extent and frequency of VCP‐immunoreactive structures in these neurodegenerative diseases are uncertain. We immunohistochemically examined the brains of 72 cases with neurodegenerative diseases and five control cases. VCP immunoreactivity was present in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and neuronal nuclear inclusions in five polyglutamine diseases and intranuclear inclusion body disease, as well as in Marinesco bodies in aged control subjects. However, other neuronal and glial cytoplasmic inclusions in tauopathies and TDP‐43 proteinopathies were unstained. These findings suggest that VCP may have common mechanisms in the formation or degradation of cytoplasmic and nuclear inclusions of neurons, but not of glial cells, in several neurodegenerative conditions. 相似文献
63.
Tokuda Yoshiyuki Fujimoto Kazuro Narita Yuji Mutsuga Masato Terazawa Sachie Ito Hideki Matsumura Yasumoto Uchida Wataru Munakata Hisaaki Ashida Shinichi Ono Tsukasa Nishi Toshihiko Yano Daisuke Ishida Shinichi Kuwabara Fumiaki Akita Toshiaki Usui Akihiko 《Surgery today》2020,50(2):106-113
Surgery Today - Postoperative spinal cord injury is a devastating complication after aortic arch replacement. The purpose of this study was to determine the predictors of this complication. A group... 相似文献
64.
65.
Yuki Nakamura Fumiaki Shikata Masahiro Ryugo Toru Okamura Takumi Yasugi Hironori Izutani 《Surgery today》2014,44(12):2378-2381
Hereditary hemorrhagic telangiectasia (HHT) is caused by an autosomal dominant gene and characterized by multiple arteriovenous malformations in several organs, leading to bleeding or shunting. These patients often suffer severe infections and heart failure, which should be managed in the perioperative period, when open heart surgery is indicated. We report a case of successful aortic root replacement for active prosthetic valve endocarditis and ventricular septal perforation in a patient with HHT, who had severe heart failure. 相似文献
66.
Sayaka Otake Norio Suzuki Atsushi Takahashi Fumiaki Toki Akira Nishi Hideki Yamamoto Minoru Kuroiwa Hiroyuki Kuwano 《Surgery today》2014,44(8):1400-1405
Background/purpose
To clarify the role of interval appendectomy (IA) in pediatric patients with acute appendicitis with an appendiceal inflammatory mass or abscess, we histologically analyzed the appendices removed during IA.Patients and methods
We treated 355 consecutive pediatric patients with acute appendicitis and reviewed the admission charts of patients who started conservative management (CM). The histology of the appendix removed during IA was also examined. The relationships among the clinical features, appendicolith formation at the time of IA and histological findings were analyzed by stepwise regression analyses.Results
(1) CM was started in 48 patients (13.5 %). Recurrence or a remaining abscess was observed in nine patients (18.8 %). (2) Histopathological changes, particularly foreign body reaction with fibrosis and infiltration of inflammatory cells, were observed in about half of the specimens. (3) In a stepwise regression analysis, the presence of an appendicolith at IA was correlated with an appendicolith at diagnosis, foreign body reaction in the appendix and a decrease in the inflammatory reaction at diagnosis.Conclusion
More than half the patients had strong histopathological changes in the appendix, suggesting a high possibility of recurrence. The presence of appendicolith formation at IA, which is a risk factor for recurrence, was influenced by the presence of an appendicolith at diagnosis, foreign body reaction in the appendix and the inflammatory status of patients at diagnosis. These clinical findings are indications for IA. 相似文献67.
Masahiko Noguchi MD Minoru Tabata MD Kotaro Obunai MD Kentaro Shibayama MD Joji Ito MD Hiroyuki Watanabe MD Fumiaki Yashima MD Yusuke Watanabe MD Toru Naganuma MD Motoharu Araki MD Futoshi Yamanaka MD Shinichi Shirai MD Hiroshi Ueno MD Kazuki Mizutani MD Akihiro Higashimori MD Kensuke Takagi MD Norio Tada MD Masanori Yamamoto MD Kentaro Hayashida MD 《Catheterization and cardiovascular interventions》2021,97(1):E113-E120
68.
Shuichi Ishiyama Akira Fuse Hiroshi Kuzu Joji Tanaka Masahiro Urayama Yukio Igarashi Fumiaki Sakurai Kiyoshi Kawaguchi Masaru Tsukamoto Tadashi Nakamura Shuji Koike 《Journal of hepato-biliary-pancreatic sciences》1997,4(4):417-422
A microsurgical technique was used in performing anterior hepatic segmentectomy and pancreatoduodenectomy with reconstruction of the posterior hepatic artery in a 64-year-old man with widespread bile duct cancer from the intrapancreatic bile duct over the hepatic hilus. The anterior hepatic artery was obviously involved and the posterior hepatic artery just behind common hepatic duct was very close to the cancer. Microsurgical anastomosis between the remnant gastroduodenal artery and the posterior hepatic artery at the hepatic hilus made it possible to preserve the posterior segment of the liver and to perform a curative resection of the cancer. The patient had pyrexia because of suprahepatic abscess after the operation, but the abscess drained spontaneously. Postoperative arteriogram showed neither obstruction nor kinking of the reconstructed artery. He was discharged 2 months after surgery and has been enjoying a normal quality of life for 10 months since, with no signs of recurrence. It is suggested that a microsurgical technique is useful for performing an accurate anastomosis with good patency that allows not only a safe but also a highly curative operation for advanced bile duct cancer. 相似文献
69.
Relationships between polymorphisms of the human serum paraoxonase gene and insulin sensitivity in Japanese patients with type 2 diabetes 总被引:6,自引:0,他引:6
Ikeda Y Suehiro T Ohsaki F Arii K Kumon Y Hashimoto K 《Diabetes research and clinical practice》2003,60(2):79-85
Human serum paraoxonase (PON1), which is associated with HDL, is an esterase and has been shown to reduce the susceptibility of LDL to lipid peroxidation. The objective of the study was to determine whether genetic polymorphisms of the PON1 gene are associated with insulin sensitivity. Forty-eight Japanese patients with type 2 diabetes were recruited, and euglycemic hyperinsulinemic clamp was performed to assess insulin sensitivity. The PON1 promoter polymorphism C(-108)T was determined by direct sequencing, and the coding region polymorphism Q192R was determined by polymerase chain reaction and digestion of the amplified fragments. No association was observed between the Q192R polymorphism and the glucose infusion rate (GIR), whereas GIR increased with the following order of genotypes: -108TT < -108CT < and -108CC (4.2+/-1.6, 5.1+/-2.5, and 6.9+/-2.5 mg kg(-1) min(-1), respectively; P<0.02, ANCOVA). Stepwise regression analysis revealed that the C(-108)T polymorphism significantly contributed to the GIR. It has been reported that oxidative stress attenuates insulin signaling in vitro. The PON1 promoter polymorphism C(-108)T may influence insulin sensitivity by modulating serum antioxidant capacity. 相似文献