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Anne Vrieze Carolien Out Susana Fuentes Lisanne Jonker Isaie Reuling Ruud S. Kootte Els van Nood Frits Holleman Max Knaapen Johannes A. Romijn Maarten R. Soeters Ellen E. Blaak Geesje M. Dallinga-Thie Dorien Reijnders Mariëtte T. Ackermans Mireille J. Serlie Filip K. Knop Jenst J. Holst Claude van der Ley Ido P. Kema Erwin G. Zoetendal Willem M. de Vos Joost B.L. Hoekstra Erik S. Stroes Albert K. Groen Max Nieuwdorp 《Journal of hepatology》2014
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Daniel Prefasi Blanca Fuentes Patricia Martínez-Sánchez Ana Rodríguez-Sanz Gerardo Ruiz-Ares Borja Sanz-Cuesta Manuel Lara Lara Exuperio Díez-Tejedor 《Journal of thrombosis and thrombolysis》2014,37(4):557-564
The effect of intravenous thrombolysis (IVT) according to etiology and stroke severity in young patients with ischemic stroke (IS) has not been described previously. To analyze the effect of IVT in young patients with IS according to etiological subtype and stroke severity. Observational study with inclusion of IS patients under 55 years of age (2007–2012). Two groups were compared according to IVT treatment. Favorable outcomes were defined as 3 months modified Rankin Scale ≤2. Multivariate analyses were performed to determine those factors independently associated with favorable outcomes, and subgroup analyses were conducted to assess the effect of IVT according to etiological stroke subtype and severity on admission, adjusted for other prognostic variables. We evaluated 262 patients. 63 (24 %) received IVT. The mean age and the sex distribution were similar in the IVT treated and the non-treated groups. Multivariate analyses showed that IVT was associated with a higher probability of favorable outcome (OR, 95 % CI: 4.652, 1.294–16.722) whereas artery dissection (OR, 95 % CI: 0.191, 0.056–0.654) and NIHSS (OR, 95 % CI: 0.727, 0.664–0.797) were associated with a lower probability of a favorable outcome. The subgroup analysis showed that the beneficial effect of IVT on outcomes was significant in moderate-severe strokes (NIHSS ≥8) (OR, 95 % CI: 3.782, 1.095–13.069) and in cardioembolism (OR, 95 % CI: 41.887, 1.001–1751.596). In IS patients under 55 years of age, those with moderate-severe strokes benefit more from IVT than those with mild strokes. Cardioembolic infarctions may benefit more from IV tPA than other etiologies. 相似文献
994.
Javier Delgado‐Lista Antonio Garcia‐Rios Francisco Gomez‐Delgado Carmen Marin‐Hinojosa Fernando Rodriguez‐Cantalejo Nieves Delgado‐Casado Ana I. Perez‐Caballero Francisco J. Fuentes‐Jimenez Antonio Camargo Francisco J. Tinahones Jose M. Ordovas Francisco Perez‐Jimenez Jose Lopez‐Miranda 《European journal of clinical investigation》2014,44(11):1053-1064
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M. Rodríguez-Yañez M. Gómez-Choco E. López-Cancio S. Amaro M. Alonso de Leciñana J.F. Arenillas O. Ayo-Martín M. Castellanos M.M. Freijo A. García-Pastor M. Gomis P. Martínez Sánchez A. Morales E.J. Palacio-Portilla J. Roquer T. Segura J. Serena J. Vivancos-Mora B. Fuentes 《Neurología (Barcelona, Spain)》2021,36(6):462-471
ObjectiveTo update the recommendations of the Spanish Society of Neurology on primary and secondary stroke prevention in patients with arterial hypertension.DevelopmentWe proposed several questions to identify practical issues for the management of blood pressure (BP) in stroke prevention, analysing the objectives of blood pressure control, which drugs are most appropriate in primary prevention, when antihypertensive treatment should be started after a stroke, what levels we should aim to achieve, and which drugs are most appropriate in secondary stroke prevention. We conducted a systematic review of the PubMed database and analysed the main clinical trials to address these questions and establish a series of recommendations.ConclusionsIn primary stroke prevention, antihypertensive treatment should be started in patients with BP levels > 140/90 mmHg, with a target BP of < 130/80 mmHg. In secondary stroke prevention, we recommend starting antihypertensive treatment after the acute phase (first 24 hours), with a target BP of < 130/80 mmHg. The use of angiotensin-II receptor antagonists or diuretics alone or in combination with angiotensin-converting enzyme inhibitors is preferable. 相似文献
999.
Laura Fionda Janina Turon‐Sans Pablo Fuentes Prior Sara Bernal Noguera Elena Corts‐Vicente Maria Angeles Lpez‐Prez Eduard Gallardo Ricard Rojas‐García 《Journal of the peripheral nervous system : JPNS》2021,26(1):113-117
We report the case of a patient with a clinical phenotype characterized by distal lower limb weakness and pes cavus. The electrophysiological study showed slightly reduced or normal amplitude of motor potentials, a decremental response to repetitive nerve stimulation and post‐exercise facilitation. Muscle biopsy showed only mild neurogenic features. Genetic analysis included a clinical exome sequencing, followed by Sanger analysis. Three‐dimensional (3D) models were generated with a SwissModel ( https://swissmodel.expasy.org/ ) to explain the clinical observations and reinforce the pathogenic nature of the genetic variant identified. Genetic analysis demonstrated a new de novo heterozygous in frame deletion of the SYT2 gene (NM_177402.4: c.1082_1096del), confirmed by Sanger sequencing, which removes five aminoacids in the C2B domain of synaptotagmin‐2 protein, that cause a profound effect on the structure and function of this synaptic vesicle protein. We identified a de novo genetic variant in the SYT2 gene, further supporting its association with a highly stereotyped clinical and electrophysiological phenotype. Our case showed electrophysiological features consistent with a presynaptic dysfunction in the neuromuscular junction with normal post‐exercise amplitudes, not supporting the presence of predominant axonal damage. Although the analysis of SYT2 gene should be included in genetic analysis of patients presenting with this clinical phenotype that mimics motor neuropathy, clinicians have to consider the study of neuromuscular transmission to early identify this potentially treatable condition. 相似文献
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