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71.
Kurth AE Martin DP Golden MR Weiss NS Heagerty PJ Spielberg F Handsfield HH Holmes KK 《Sexually transmitted diseases》2004,31(12):719-726
OBJECTIVE: The objective of this study was to compare reporting between audio computer-assisted self-interview (ACASI) and clinician-administered sexual histories. GOAL: The goal of this study was to explore the usefulness of ACASI in sexually transmitted disease (STD) clinics. STUDY: The authors conducted a cross-sectional study of ACASI followed by a clinician history (CH) among 609 patients (52% male, 59% white) in an urban, public STD clinic. We assessed completeness of data, item prevalence, and report concordance for sexual history and patient characteristic variables classified as socially neutral (n=5), sensitive (n=11), or rewarded (n=4). RESULTS: Women more often reported by ACASI than during CH same-sex behavior (19.6% vs. 11.5%), oral sex (67.3% vs. 50.0%), transactional sex (20.7% vs. 9.8%), and amphetamine use (4.9% vs. 0.7%) but were less likely to report STD symptoms (55.4% vs. 63.7%; all McNemar chi-squared P values <0.003). Men's reporting was similar between interviews, except for ever having had sex with another man (36.9% ACASI vs. 28.7% CH, P <0.001). Reporting agreement as measured by kappas and intraclass correlation coefficients was only moderate for socially sensitive and rewarded variables but was substantial or almost perfect for socially neutral variables. ACASI data tended to be more complete. ACASI was acceptable to 89% of participants. CONCLUSIONS: ACASI sexual histories may help to identify persons at risk for STDs. 相似文献
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Tumoral pancreatic islet cells of either the RINm5F or INS-1 cell lines, when cultured in the presence of 30.0 mM D-glucose, accumulate about 50 times more glycogen than tumoral pancreatic acinar cells of the AR42J line cultured under the same experimental conditions. Expressed per nl of intracellular water, the glycogen content of the RINm5F or INS-1 cells is even higher than that found in rat pancreatic islets also cultured under the same experimental conditions. Moreover, at variance with normal islet cells, tumoral islet cells do not require to be exposed to a high concentration of D-glucose to accumulate large amounts of glycogen. Based on these findings, it is proposed that the labelling of the glycogen pool, e.g. by 11C-labelled D-glucose or 2-deoxy-2-[18F]fluoro-D-glucose, may allow identification and localization of insulinomas in the pancreatic gland by a non-invasive imaging procedure. 相似文献
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D'Haenens W Vinck BM De Vel E Maes L Bockstael A Keppler H Philips B Swinnen F Dhooge I 《International journal of audiology》2008,47(8):489-498
The test-retest reliability of the auditory steady-state response (ASSR) has received limited attention. Therefore, the aim was to assess the test-retest reliability of an 80-Hz multiple-ASSR system in normal-hearing subjects by a comprehensive set of statistical methods. Twenty-nine participants (15 females) aged between 18 and 30 years contributed to two sessions (test-retest), and the ASSR thresholds were determined with a descending search protocol using a 10-dB precision. The test-retest reliability was assessed by a three-layered approach which consisted of Pearson product-moment correlation, analysis of variance (ANOVA), and standard error of measurement (SEM). The correlations for ASSR thresholds ranged from poor (0.34) for 500 Hz CF to moderate (0.55) for 1000, 2000, and 4000 Hz CF. A two-way ANOVA of the difference scores (ASSR threshold minus behavioral threshold) demonstrated no significant difference between test and retest. The SEM determined the normal tolerance for clinical error of repeated thresholds and the ASSR SEM values fell well within +/-10 dB HL. This investigation shows that the multiple ASSR-technique produces a clinically acceptable test-retest reliability for normal-hearing adults. 相似文献
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Koch Gilbert Steffens Britta Leroux Stephanie Gotta Verena Schropp Johannes Gächter Pascal Bachmann Freya Welzel Tatjana Janner Marco L’Allemand Dagmar Konrad Daniel Szinnai Gabor Pfister Marc 《Journal of pharmacokinetics and pharmacodynamics》2021,48(5):711-723
Journal of Pharmacokinetics and Pharmacodynamics - Modeling of retrospectively collected multi-center data of a rare disease in pediatrics is challenging because laboratory data can stem from... 相似文献