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排序方式: 共有2540条查询结果,搜索用时 812 毫秒
81.
Juliana Duarte Leandro Olavo Ribeiro Rodrigues Annie France Frere Slaets Aurelino F. Schmidt Jr Milton L. Yaekashi 《Jornal brasileiro de pneumologia》2014,40(4):389-396
OBJECTIVE:
To compare two thoracotomy closure techniques (pericostal and transcostal suture) in terms of postoperative pain and pulmonary function.METHODS:
This was a prospective, randomized, double-blind study carried out in the Department of Thoracic Surgery of the Luzia de Pinho Melo Hospital das Clínicas and at the University of Mogi das Cruzes, both located in the city of Mogi das Cruzes, Brazil. We included 30 patients (18-75 years of age) undergoing posterolateral or anterolateral thoracotomy. The patients were randomized into two groups by the type of thoracotomy closure: pericostal suture (PS; n = 16) and transcostal suture (TS; n = 14). Pain intensity during the immediate and late postoperative periods was assessed by a visual analogic scale and the McGill Pain Questionnaire. Spirometry variables (FEV1, FVC, FEV1/FVC ratio, and PEF) were determined in the preoperative period and on postoperative days 21 and 60.RESULTS:
Pain intensity was significantly greater in the PS group than in the TS group. Between the preoperative and postoperative periods, there were decreases in the spirometry variables studied. Those decreases were significant in the PS group but not in the TS group.CONCLUSIONS:
The patients in the TS group experienced less immediate and late post-thoracotomy pain than did those in the PS group, as well as showing smaller reductions in the spirometry parameters. Therefore, transcostal suture is recommended over pericostal suture as the thoracotomy closure technique of choice. 相似文献82.
Dennis J Johnson CY Adediran AS de Andrade M Heit JA Morange PE Trégouët DA Gagnon F 《Blood》2012,119(10):2392-2400
The endothelial protein C receptor (EPCR) limits thrombus formation by enhancing activation of the protein C anticoagulant pathway, and therefore may play a role in the etiology of thrombotic disorders. The rs867186 single-nucleotide polymorphism in the PROCR gene (g.6936A > G, c.4600A > G), resulting in a serine-to-glycine substitution at codon 219, has been associated with reduced activation of the protein C pathway, although its association with thrombosis risk remains unclear. The present study is a highly comprehensive systematic review and meta-analysis, including unpublished genome-wide association study results, conducted to evaluate the evidence for an association between rs867186 and 2 common thrombotic outcomes, venous thromboembolism (VTE) and myocardial infarction (MI), which are hypothesized to share some etiologic pathways. MEDLINE, EMBASE, and HuGE Navigator were searched through July 2011 to identify relevant epidemiologic studies, and data were summarized using random-effects meta-analysis. Twelve candidate genes and 13 genome-wide association studies were analyzed (11 VTE and 14 MI, including 37,415 cases and 84,406 noncases). Under the additive genetic model, the odds of VTE increased by a factor of 1.22 (95% confidence interval, 1.11-1.33, P < .001) for every additional copy of the G allele. No evidence for association with MI was observed. 相似文献
83.
Bouleti C Iung B Laouénan C Himbert D Brochet E Messika-Zeitoun D Détaint D Garbarz E Cormier B Michel PL Mentré F Vahanian A 《Circulation》2012,125(17):2119-2127
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86.
Emilie Morin France Berthelet John Weisnagel Martin Bidlingmaier Omar Serri 《Pituitary》2012,15(1):97-100
It has been suggested that treatment with adequate dose titration of pegvisomant, a GH antagonist, up to a maximum of 40 mg
daily, can achieve IGF-1 normalisation in virtually all patients with acromegaly. On the other hand, temozolomide (TMZ), an
alkylating cytostatic agent, has been reported to reduce pituitary tumour size and hormone hypersecretion in a small number
of aggressive pituitary macroadenomas. In this paper we report the case of a patient resistant to very high doses of pegvisomant
used in combination with somatostatin analogs (SSA) and to TMZ therapy. The patient, initially a 22 year-old man with an invasive
GH-secreting pituitary macroadenoma (IGF-1, 371% upper limit of normal), had active acromegaly despite a repeat transsphenoidal
surgery followed by radiotherapy and SSA (octreotide 800 μg sc daily) (IGF-1, 262% ULN). In combination with SSA, pegvisomant
was started at 20 mg daily and doses were titrated up to 60 mg daily. IGF-1 was moderately reduced and stabilized at 200%
ULN after 1 year of treatment. Serum pegvisomant level was 30,500 ng/l, the denaturalized GHBP concentration 1,120 pM and
the endogenous GH level was 220 μg/l. Pegvisomant was stopped and TMZ therapy was given for 5 cycles. However, the patient
reported an increase of acromegaly symptoms and the serum IGF-1 was raised to the same level prior to pegvisomant therapy.
Consequently, pegvisomant was tried again with doses up to 100 mg daily finally resulting in normalisation of serum IGF-1
level and improvement of acromegaly symptoms and patient well-being. We conclude that in some patients with severe acromegaly
refractory to multimodal therapy, biochemical control may be difficult to attain with conventional doses of pegvisomant or
TMZ therapy. 相似文献
87.
88.
Dominique Bertrand Geoffroy Desbuissons Nicolas Pallet Alain Debure Albane Sartorius Dany Anglicheau Marie‐France Mamzer Christophe Legendre Rebecca Sberro‐Soussan 《Transplant international》2013,26(2):e4-e7
The side‐effects associated with the immunosuppressive drug sirolimus are numerous and constitute a major limitation for its use in renal transplantation. In this study, we describe two cases of renal transplant recipients treated with sirolimus who developed pericardial tamponade associated with interstitial pneumonia, proteinuria, microcytic anemia and, in one case, lymphocytic meningitidis. An extensive search for infectious agents was negative, and all symptoms disappeared after sirolimus interruption. Therefore, this case demonstrates for the first time that sirolimus can cause pericardial tamponade as well as lymphocytic meningitidis. 相似文献
89.
Abdallah Fayssoil Lee S. Nguyen Tanya Stojkovic Helene Prigent Robert Carlier Helge Amthor Jean Bergounioux Justine Zini Sebastien Damez-Fontaine Karim Wahbi Pascal Laforet Guillaume Nicolas Anthony Behin Guillaume Bassez France Leturcq Rabah Ben Yaou Nicolas Mansencal Djillali Annane Frdric Lofaso David Orlikowski 《Muscle & nerve》2022,65(1):89-95