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991.
992.
Naiara Abreu de Azevedo Fraga Maria de Fátima Paim de Oliveira Ivonise Follador Bruno de Oliveira Rocha Vitória Regina Rêgo 《Anais brasileiros de dermatologia》2012,87(6):877-883
Psoriasis is a systemic, chronic, immunologically mediated disease, with significant
genetic and environmental influences. It affects from 1 to 3% of the world
population. Recently, the relation between psoriasis and different comorbidities,
particularly metabolic syndrome, has become extremely relevant. Uveitis is
characterized by a process of intraocular inflammation resulting from various causes.
Considering psoriasis and uveitis as immune-mediated diseases, this study aims to
evaluate the possible association of psoriasis and/or psoriatic arthritis with
uveitis and its subtypes. Few studies have evaluated the association of uveitis and
psoriasis without joint involvement. It seems that psoriasis without arthropathy is
not a risk factor for the development of uveitis. Uveitis tends to develop more
frequently in patients with arthropathy or pustular psoriasis than in patients with
other forms of psoriasis. Ophthalmic examination should be performed periodically in
patients with psoriasis and uveitis. If ophthalmopathy is diagnosed, the patient
should receive adequate treatment with anti-inflammatory drugs or immunomodulators to
prevent vision loss. 相似文献
993.
Non-melanoma skin cancer (NMSC) is the most common cancer in humans. Basal cell carcinoma accounts for 75 percent to 80 percent of NMSC. We report a primary cutaneous BCC on the upper chest in which vascular invasion was demonstrated by histopathology and the unique application of dual immunohistochemistry. 相似文献
994.
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996.
Objective
The therapeutic management of parapneumonic pleural effusions (PPE) is controversial in children. Decision-making often relies on parameters such as gross appearance of pleural fluid and on bacteriologic and biochemical analyses. Our goal was to describe the laboratory profile of PPE in children and to assess the influence of previous administration of antibacterial agents on culture and biochemical results.Patients and methods
This was a prospective study including children (age, 1 month to 16 years) with a diagnosis of PPE. Two groups were evaluated: children with or without antibiotic treatment up to 48 hours before analysis of pleural fluid. Results were analyzed using the χ2 or Mann-Whitney test (α = .05). Odds ratio and 95% confidence intervals (95% CIs) were calculated, with control of previous antibiotic therapy using multivariate logistic regression analysis, to determine the risk of empyema associated with specific biochemical parameters.Results
One hundred ten children were selected. Fifty percent had received antibiotics at least 48 hours before pleural fluid analysis. Differences were observed between the groups in terms of PPE gross appearance (P = .033) and identification of bacteriologic agent by culture or Gram stain (P = .023). Biochemical parameters (pH ≤7.1 and glucose ≤40 mg/dL) were associated with increased odds of receiving a more invasive treatment. For pH, the odds ratio was 9.614 (95% CI, 1.952-47.362; P = .005); and for glucose, 9.201 (95% CI, 1.333-63.496; P = .024).Conclusions
Previous use of antibacterial agents affected the bacteriologic analysis of pleural fluid in this pediatric sample admitted for PPE. However, it did not interfere significantly with biochemical parameters of pleural fluid. 相似文献997.
Hochberg Z Feil R Constancia M Fraga M Junien C Carel JC Boileau P Le Bouc Y Deal CL Lillycrop K Scharfmann R Sheppard A Skinner M Szyf M Waterland RA Waxman DJ Whitelaw E Ong K Albertsson-Wikland K 《Endocrine reviews》2011,32(2):159-224
Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs. 相似文献
998.
Monica D. Ulibarri Steffanie A. Strathdee Emilio C. Ulloa Remedios Lozada Miguel A. Fraga Carlos Magis-Rodríguez Adela De La Torre Hortensia Amaro Patricia O’Campo Thomas L. Patterson 《AIDS and behavior》2011,15(1):179-185
We examined relationships between client-perpetrated emotional, physical, and sexual abuse, injection drug use, and HIV-serostatus
among 924 female sex workers (FSWs) in Tijuana and Ciudad Juarez, two large Mexico-US border cities. We hypothesized that
FSWs’ injection drug use would mediate the relationship between client-perpetrated abuse and HIV-seropositivity. The prevalence
of client-perpetrated emotional, physical, and sexual abuse in the past 6 months was 26, 18, and 10% respectively; prevalence
of current injection drug use and HIV was 12 and 6%, respectively. Logistic regression analyses revealed that client-perpetrated
sexual abuse was significantly associated with HIV-seropositivity and injection drug use, and that injection drug use was
positively associated with HIV-seropositivity. Injection drug use partially mediated the relationship between client-perpetrated
sexual abuse and HIV-seropositivity. Results suggest the need to address client-perpetrated violence and injection drug use
when assessing HIV risk among FSWs. 相似文献
999.
Pedro HS Pereira MI Goloni MR Pires FC Oliveira RS da Rocha MA Conceição LM Fraga VD Fenley JC Cordeschi T Machado RL Franco C Rossit AR 《Tropical medicine & international health : TM & IH》2011,16(1):67-73
Objective To evaluate retrospectively the microbiological profile of Mycobacterium species isolated from HIV‐infected patients attending the HIV/TB reference health care units in São José do Rio Preto, Brazil. Method Retrospective evaluation of all HIV‐1 positive patients whose IAL‐SJRP laboratorial analysis was positive for Mycobacterium sp. after diagnosis of HIV Infection, from January 2000 to December 2006. Results Of 198 patients, acid‐fast staining detected mycobacteria early in 41%. Culture revealed 52.5% to be infected with Mycobacterium tuberculosis (MT). 42.4% had non‐tuberculous mycobacteria (NTM) and 5.1% had MT/NTM positive cultures. Eleven per cent of MT strains were resistant to at least one of the antimycobacterial drugs and 3.1% were multidrug resistant. 39.4% of isolated mycobacteria were NTM species. Conclusion Our data may serve as a starting point for further comparisons with other Brazilian regions and other developing countries. The data may provide important clues to the future understanding, prevention and control of such co‐infections around the world. 相似文献
1000.
Haillot O Fraga A Maciukiewicz P Pushkar D Tammela T Höfner K Chantada V Gagnier P Morrill B 《Prostate cancer and prostatic diseases》2011,14(4):302-306
CombAT (Combination of Avodart and Tamsulosin) was a randomised, double-blind study in men (n=4844) aged ≥ 50 years with a clinical diagnosis of BPH. Patients were randomised to daily tamsulosin 0.4 mg, dutasteride 0.5 mg or both for 4 years. The primary endpoint was time to acute urinary retention (AUR) or BPH-related surgery. Secondary endpoints included BPH clinical progression, symptoms and maximum urinary flow rate. A post hoc analysis of data from the European subgroup was conducted. A total of 2925 men were randomised to treatment in Europe as part of CombAT (tamsulosin, n=972; dutasteride, n=970; combination, n=983). Combination therapy significantly reduced the relative risk of AUR or BPH-related surgery compared with either monotherapy at 4 years, and also significantly reduced the risk of BPH clinical progression. Combination therapy also provided significantly greater symptom improvement than either monotherapy at 4 years. Safety and tolerability of dutasteride plus tamsulosin was consistent with previous experience of this combination and with the monotherapies. These data provide further evidence to support the use of long-term combination therapy (dutasteride plus tamsulosin) in men with moderate-to-severe lower urinary tract symptoms because of BPH and prostatic enlargement. The results in the European subgroup are generally consistent with those in the overall study population. 相似文献