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161.
Heinrich Scheiblauer Angela Filomena Andreas Nitsche Andreas Puyskens Victor M Corman Christian Drosten Karin Zwirglmaier Constanze Lange Petra Emmerich Michael Müller Olivia Knauer C Micha Nübling 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2021,26(44)
IntroductionNumerous CE-marked SARS-CoV-2 antigen rapid diagnostic tests (Ag RDT) are offered in Europe, several of them with unconfirmed quality claims.AimWe performed an independent head-to-head evaluation of the sensitivity of SARS-CoV-2 Ag RDT offered in Germany.MethodsWe addressed the sensitivity of 122 Ag RDT in direct comparison using a common evaluation panel comprised of 50 specimens. Minimum sensitivity of 75% for panel specimens with a PCR quantification cycle (Cq) ≤ 25 was used to identify Ag RDT eligible for reimbursement in the German healthcare system.ResultsThe sensitivity of different SARS-CoV-2 Ag RDT varied over a wide range. The sensitivity limit of 75% for panel members with Cq ≤ 25 was met by 96 of the 122 tests evaluated; 26 tests exhibited lower sensitivity, few of which failed completely. Some RDT exhibited high sensitivity, e.g. 97.5 % for Cq < 30.ConclusionsThis comparative evaluation succeeded in distinguishing less sensitive from better performing Ag RDT. Most of the evaluated Ag RDT appeared to be suitable for fast identification of acute infections associated with high viral loads. Market access of SARS-CoV-2 Ag RDT should be based on minimal requirements for sensitivity and specificity. 相似文献
162.
Bajpai R Brizhik L Del Giudice E Finelli F Popp FA Schlebusch KP 《Journal of acupuncture and meridian studies》2010,3(4):291-297
It has been reported that the colors perceived behind closed eyes provide an indication of the psychophysical state of a subject. We discuss this phenomenon in the light of recently developed approaches to living organisms, based on the interplay between matter organization, biochemistry and electrodynamics. "When there is no energy, there is no color, no shape, no life." Caravaggio (1571-1610). 相似文献
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Daniela Monaco Daniela Berg Astrid Thomas Vincenzo Di Stefano Filomena Barbone Michela Vitale Camilla Ferrante Laura Bonanni Marta Di Nicola Tonia Garzarella Luciano Paolo Marchionno Giovanni Malferrari Rocco Di Mascio Marco Onofrj Raffaella Franciotti 《Neurological sciences》2018,39(11):1887-1894
Transcranial sonography (TCS) is a noninvasive, easily performed, and commonly available neuroimaging technique useful for the study of brain parenchyma in movement disorders. This tool has been increasingly used in the diagnosis of Parkinson’s disease and atypical parkinsonism. The aim of the study was to evaluate the applicability of this technique as supportive tool in the early diagnosis of movement disorders. We performed TCS on 315 individuals which were diagnosed as healthy controls or affected by idiopathic Parkinson’s disease, monogenetic subtypes of Parkinson’s disease, atypical parkinsonism, and Dementia with Lewy bodies. Five TCS diagnostic patterns were defined on the basis of substantia nigra’s and lenticular nuclei’s echogenicity. TCS evaluations were performed by two blinded neuro-sonographers. Clinical diagnosis on all individuals was performed at baseline and at 4-year follow-up. The concordance rate between TCS patterns and clinical diagnosis and the specificity of TCS pattern to discriminate each group of individuals were compared at baseline and at follow-up. The concordance rate between TCS patterns and clinical diagnosis of all individuals was 84% at baseline and increased at follow-up (91%) significantly (p?=?0.01). The specificity of TCS pattern in the comparison between patients diagnosed as affected by idiopathic Parkinson’s disease and atypical parkinsonism showed a significant increase at follow-up (p?=?0.03). Our study strongly confirms the role of TCS as a noninvasive and cost-effective tool in early diagnosis of movement disorders. 相似文献
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Cross‐sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis
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Miguel Costa‐Silva MD Joana Sobrinho‐Simões MD Filomena Azevedo MD Carmen Lisboa PhD 《International journal of dermatology》2018,57(1):46-49
Background
Syphilis remains a major challenge and a complex diagnosis. We aim to evaluate the role of polymerase chain reaction (PCR) in Treponema pallidum (Tp) detection in various types of biological samples in the diagnosis of early syphilis.Methods
We conducted a cross‐sectional study including all attendees of the STI clinic with clinical suspicion of early syphilis. One or more specimens for the detection of Tp by PCR testing were collected.Results
The overall sensitivity of Tp PCR test was 82.61% (95% CI: 68.6–92.2%). Tp PCR test had sensitivity of 84.6% (95% CI: 54.6–98.1%) in primary syphilis cases and 81.8% (95% CI: 64.5–93%) in secondary syphilis cases. PCR test performance was independent of HIV status.Conclusion
Tp PCR test is a fast and reliable method for the detection of Tp in skin lesions of early syphilis, and it is a powerful tool in clinical settings. 相似文献168.
Rita Marinheiro Leonor Parreira Pedro Amador Cláudia Lopes Andreia Fernandes Dinis Mesquita José Farinha Marta Fonseca Tatiana Duarte Rui Caria 《Journal of stroke and cerebrovascular diseases》2019,28(4):971-979
Background: Atrial high-rate episodes (AHREs) are common in pacemaker patients. Our aims were to compare patients with AHREs to those without them and to assess if, in those with AHREs, the initiation of oral anticoagulation (OAC) has any clinical impact on the occurrence of ischemic and hemorrhagic events. Methods: From 2014-2017 we selected patients with pacemaker in whom AHREs were detected. AHREs were defined as episodes lasting more than 6 minutes if the electrogram was available or more than 6 hours if not. We used an age- and gender-matched population with pacemaker but no AHRE as a control group (observational study). Those with AHRE were referred to their assistant physician to decide OAC initiation, based on individual circumstances (interventional study). In interventional study, the primary outcome was a composite of systemic thromboembolism or major bleeding. Secondary outcomes were clinical relevant nonmajor bleeding, major and nonmajor bleeding, CV death, and death from all causes. Results: AHREs were detected in 86 patients: 69 patients initiated OAC and the remaining 17 patients did not. When comparing patients with and without AHRE, baseline characteristics were not different between the groups, except for indexed left atrium volume—40 mL (IQR: 34-50) in AHRE group versus 35 mL (IQR: 34-40) in control group (P?=?.014). AHREs were associated with future development of atrial fibrillation (AF) and the risk was higher if AHRE duration was superior to 6 hours. Death and cardiovascular (CV) death were not significantly different between the groups with and without AHRE. Primary outcome occurred in 4.9 per 100 person-year in OAC group versus 3.4 per 100 person-year in non-OAC group (HR 1.4, 95% CI .2-11.3, P?=?.78). Secondary outcomes were not significantly different in the groups. Conclusions: In this group of patients with pacemakers, the presence of AHREs was useful for predicting the future development of AF and the risk of AF was higher in those with a longer duration of AHRE. In the AHRE group, OAC therapy was not associated with a significant difference in the risk of thromboembolism or major bleeding. 相似文献
169.
Rodríguez-Rivera Carmen Pérez-García Carmen Muñoz-Rodríguez José Ramón Vicente-Rodríguez Marta Polo Filomena Ford Rhian-Marie Segura Esperanza León Alberto Salas Elisabet Sáenz-Mateos Luis González-Martín Carmen Herradón Gonzalo Beato-Fernández Luis Martín-Fernández Jesús Alguacil Luis F. 《World journal of surgery》2019,43(3):744-750
World Journal of Surgery - The current therapeutics of morbid obesity could be significantly improved after the identification of novel biomarkers associated with the food addiction endophenotype... 相似文献
170.
Catarina Moreira Paulo Morais Paulo Santos Miguel Castro Filomena Azevedo 《Anais brasileiros de dermatologia》2015,90(3):416-419
Gorlin''s syndrome is an autosomal dominant disorder, mainly characterized by the
presence of multiple and early-onset basal cell carcinomas, odontogenic keratocysts
and palmoplantar pits. We describe the case of a patient with clinical and imaging
features of Gorlin syndrome, and highlight the role of dermoscopy in the early
detection of basal cell carcinomas. In addition, we discuss the dermoscopic features
of palmar pits. 相似文献