全文获取类型
收费全文 | 2311篇 |
免费 | 195篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 87篇 |
妇产科学 | 36篇 |
基础医学 | 210篇 |
口腔科学 | 50篇 |
临床医学 | 226篇 |
内科学 | 500篇 |
皮肤病学 | 27篇 |
神经病学 | 68篇 |
特种医学 | 318篇 |
外科学 | 315篇 |
综合类 | 82篇 |
一般理论 | 1篇 |
预防医学 | 313篇 |
眼科学 | 35篇 |
药学 | 97篇 |
中国医学 | 1篇 |
肿瘤学 | 142篇 |
出版年
2021年 | 19篇 |
2020年 | 19篇 |
2019年 | 24篇 |
2018年 | 33篇 |
2017年 | 34篇 |
2016年 | 37篇 |
2015年 | 32篇 |
2014年 | 54篇 |
2013年 | 60篇 |
2012年 | 75篇 |
2011年 | 88篇 |
2010年 | 73篇 |
2009年 | 75篇 |
2008年 | 76篇 |
2007年 | 66篇 |
2006年 | 74篇 |
2005年 | 70篇 |
2004年 | 75篇 |
2003年 | 64篇 |
2002年 | 70篇 |
2001年 | 55篇 |
2000年 | 45篇 |
1999年 | 54篇 |
1998年 | 70篇 |
1997年 | 78篇 |
1996年 | 62篇 |
1995年 | 57篇 |
1994年 | 60篇 |
1993年 | 61篇 |
1992年 | 39篇 |
1991年 | 43篇 |
1990年 | 33篇 |
1989年 | 66篇 |
1988年 | 64篇 |
1987年 | 61篇 |
1986年 | 57篇 |
1985年 | 67篇 |
1984年 | 47篇 |
1983年 | 47篇 |
1982年 | 42篇 |
1981年 | 31篇 |
1980年 | 28篇 |
1979年 | 19篇 |
1978年 | 28篇 |
1977年 | 24篇 |
1976年 | 20篇 |
1975年 | 27篇 |
1974年 | 13篇 |
1972年 | 11篇 |
1970年 | 13篇 |
排序方式: 共有2510条查询结果,搜索用时 15 毫秒
991.
992.
Herpes zoster (HZ, also known as shingles) is caused by the reactivation of a dormant varicella zoster virus and can be a source of significant morbidity. Oral manifestations can include vesicular eruptions of the mucosa, osteonecrosis with tooth loss, and postherpetic neuralgia (PHN). This article discusses treatment for trigeminal nerve involvement with herpes zoster, as well as for the painful syndrome PHN. 相似文献
993.
994.
Effect of Physical Activity versus Health Education on Physical Function,Grip Strength and Mobility 下载免费PDF全文
Adam J. Santanasto PhD Nancy W. Glynn PhD Laura C. Lovato PhD Steven N. Blair PED Roger A. Fielding PhD Thomas M. Gill MD Jack M. Guralnik MD Fang‐Chi Hsu PhD Abby C. King PhD Elsa S. Strotmeyer PhD Todd M. Manini PhD Anthony P. Marsh PhD Mary M. McDermott MD Bret H. Goodpaster PhD Marco Pahor MD Anne B. Newman MD the LIFE Study Group 《Journal of the American Geriatrics Society》2017,65(7):1427-1433
995.
996.
997.
Reid KF Naumova EN Carabello RJ Phillips EM Fielding RA 《The journal of nutrition, health & aging》2008,12(7):493-498
Objectives: This study examined the influence of lower extremity body composition and muscle strength on the severity of mobility-disability
in community-dwelling older adults.Methods: Fifty-seven older males and females (age 74.2 ± 7 yrs; BMI 28.9 ± 6 kg/m2) underwent an objective assessment of lower extremity functional performance, the Short Physical Performance Battery test
(SPPB). Participants were subsequently classified as having moderate (SPPB score > 7: n = 38) or severe mobility impairments
(SPPB score ≤ 7: n = 19). Body composition was assessed using dual-energy X-ray absorptiometry and provided measures of bone
mineral density (BMD), total leg lean mass (TLM) and total body fat. Maximal hip extensor muscle strength was estimated using
the bilateral leg press exercise. Multiple logistic regression analysis was utilized to identify the significant independent
variables that predicted the level of mobility-disability.Results: TLM was a strong independent predictor of the level of functional impairment, after accounting for chronic medical conditions,
BMD, body fat, body weight and habitual physical activity. In a separate predictive model, reduced muscle strength was also
a significant predictor of severe functional impairment. The severity of mobility-disability was not influenced by gender
(p = 0.71). A strong association was elicited between TLM and muscle strength (r = 0.78, p < 0.01).Conclusions: These data suggest that lower extremity muscle mass is an important determinant of physical performance among functionally-limited
elders. Such findings may have important implications for the design of suitable strategies to maintain independence in older
adults with compromised physical functioning. Additional studies are warranted to assess the efficacy of lifestyle, exercise
or therapeutic interventions for increasing lean body mass in this population. 相似文献
998.
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding 总被引:1,自引:0,他引:1
Chong MF Hodson L Bickerton AS Roberts R Neville M Karpe F Frayn KN Fielding BA 《The American journal of clinical nutrition》2008,87(4):817-823
BACKGROUND: High-carbohydrate (HC) diets increase de novo lipogenesis (DNL), but effects on stearoyl-CoA desaturase (SCD) are not so well studied. OBJECTIVE: The objective was to investigate DNL and SCD in liver and adipose tissue by using fatty acid ratios after short-term dietary intervention. DESIGN: Eight subjects consumed isoenergetic 3-d HC (10% fat; 75% carbohydrates) or higher fat (HF; 40% fat; 45% carbohydrates) diets (sugar to starch ratio: 60:40 for both) in a crossover study. Blood was taken from an artery and a vein draining subcutaneous adipose tissue. DNL and SCD activity were investigated by using the ratios of 16:0 to 18:2n-6 and of 16:1n-7 to 16:0, respectively. A test meal, including [U-(13)C]palmitate was given to trace dietary fatty acid incorporation into VLDL-triacylglycerol (TG). The conversion of intravenously infused [(2)H(2)]palmitic acid to [(2)H(2)]palmitoleic acid in VLDL-TG was quantified as a specific marker of hepatic SCD activity. RESULTS: The VLDL-TG 16:0/18:2n-6 ratio, which reflects hepatic DNL, was greater after the HC diet than after the HF diet (P = 0.02). With the HC diet, increased plasma TG concentrations correlated with 16:0/18:2n-6 ratios (r = 0.76, P = 0.028). Plasma VLDL-TG and adipose venous nonesterified fatty acid (NEFA) 16:1n-7/16:0 ratios were higher after the HC diet (fasting: P = 0.01 and P = 0.05, respectively; postprandial: P = 0.03 and P = 0.05, respectively). Changes in fasting VLDL-TG 16:0/18:2n-6 and 16:1n-7/16:0 ratios were associated (P = 0.06). The contribution of total fatty acids from splanchnic sources (including DNL) was higher after the HC diet (P = 0.02). Expression of lipogenic genes in subcutaneous adipose tissue was not significantly affected by diet. CONCLUSION: Parallel activation of DNL and SCD was found after a short period of HC feeding. 相似文献
999.
1000.
郭蓓宁 《中国感染与化疗杂志》2010,10(1):67-67
泊沙康唑是一种具有广谱抗菌作用的三唑类抗真菌药,对曲霉、隐球菌、念珠菌、组织胞浆菌及酵母等有效。美国已批准泊沙康唑的适应证包括:在应用免疫抑制剂患者中的侵袭性曲霉病和念珠菌病的预防性用药,及难治性口咽部念珠菌病的治疗,而将泊沙康唑用于肺部及其他弥漫性真菌病的治疗尚处于临床研究阶段。作者以一项前瞻性、开放的临床试验进行了泊沙康唑在健康志愿者肺组织中的药动学/药效学(PK/PD)研究。 相似文献