Chronoprevention and chronotherapy of bronchial asthma

Chronobiological investigation of external respiratory function parameters was conducted in 93 patients with preasthma and bronchial asthma and in 13 healthy persons. The peculiarities of circadian organization of external respiratory parameters which were used for administration of chronotherapy were revealed in the patients. Some time before the appearance of maximum deterioration of indices under study, mostly indices of bronchial permeability, drugs (broncholytics, inhalation steroids and intal) were administered. Objective and subjective methods of assessment of bronchial permeability using a diary of self-evaluation were compared. The substitution of laboratory investigation for self-evaluation will make it possible to widely use chrono-diagnosis and chronotherapy for patients with bronchial asthma, and chronotherapy was found to be more effective than commonly used therapeutic schemes.     

Synthesis and antiradiation activity of 2-amino-4-oxo-5-amino-methyl(ethyl)thiazolines

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 7, pp. 832–834, July, 1989.     

Combined extracorporeal detoxification in the complex treatment of pancreonecrosis

Experimental investigations and experience with treatment of 74 patients with pancreonecrosis have shown the highest effectiveness of associated usage of hemosorption and external elimination of lymph from the thoracic duct. Associated detoxication for pancreonecrosis facilitates to rapidly decrease the level of the intoxication which is demonstrated by positive dynamics of biochemical and toxicological parameters of blood and lymph.     

The use of endovascular laser irradiation of the blood in the complex treatment of acute pancreatitis and peritonitis in experimental and clinical conditions

Experimental (118 experiments) and clinical (30 patients) investigations have shown a positive effect of endovascular irradiation of blood with the helium-neon and ultraviolet lasers on recovery of homeostasis in pancreatitis and peritonitis. The procedure stimulates the erythrocyte bioenergetics, reduces the degree of haemic hypoxia and increases nonspecific immunological reactivity.