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71.
Ovchinnikova I. G. Fedorova O. V. Rusinov G. L. Zueva M. N. Mordovskoi G. G. 《Pharmaceutical Chemistry Journal》2003,37(11):582-584
Pharmaceutical Chemistry Journal - 相似文献
72.
Fink-Jensen A Fedorova I Wörtwein G Woldbye DP Rasmussen T Thomsen M Bolwig TG Knitowski KM McKinzie DL Yamada M Wess J Basile A 《Journal of neuroscience research》2003,74(1):91-96
Muscarinic cholinergic receptors of the M5 subtype are expressed by dopamine-containing neurons of the ventral tegmentum. These M5 receptors modulate the activity of midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties of abused psychostimulants like cocaine. The potential role of M5 receptors in the reinforcing effects of cocaine was investigated using M5 receptor-deficient mice in a model of acute cocaine self-administration. The M5-deficient mice self-administered cocaine at a significantly lower rate than wild-type controls. In the conditioned place preference procedure, a classic test for evaluating the rewarding properties of drugs, M5-deficient mice spent significantly less time in the cocaine-paired compartment than control mice. Moreover, the severity of the cocaine withdrawal syndrome (withdrawal-associated anxiety measured in the elevated plus-maze) was significantly attenuated in mice lacking the M5 receptor. These results demonstrate that M5 receptors play an important role in mediating both cocaine-associated reinforcement and withdrawal. 相似文献
73.
The paper presents the results of examination and treatment of patients with different traumatic injuries of ear structures. The most characteristic injuries were detected in different mechanisms of traumas: mechanical (direct, indirect), altitude-induced, and thermal injuries. Major diagnostic signs of traumatic perilymphatic fistulas were revealed. The efficiency of surgical treatment for different injuries was evaluated. The surgical management of traumatic perilymphatic fistulas was comparatively assessed in different periods following injury. Evidence is provided for that it is expedient to close perilymphatic fistulas in ear injuries as early as possible. 相似文献
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75.
A single-dose cinnarizine (25 and 75 mg) was compared to its course administration (75 and 225 mg/day) in 35 patients with circulatory encephalopathy. Upon a 3-fold increase in conventional doses, there appeared more profound clinical, vasomotor cerebral and functional cerebral effects as evidenced by EEG and neuropsychological tests. 相似文献
76.
G V Neustroev V P Pomerantsev G N Gorokhovskaia E I Fedorova S A Esipenko 《Terapevticheski? arkhiv》1986,58(9):110-112
It was demonstrated with the use of the immunological tests that in acute posthemorrhagic anemias, the blood chalone content was low whereas in anemias of the leukemic origin it was elevated. In secondary erythrocytis, the chalone titre rose to a greater degree than in polycythemia vera. The testing of chalone blood factors may play a role in differential diagnosis of some types of erythropoiesis abnormalities. 相似文献
77.
Acute bronchial obstruction by mucous plugs may be manifested clinically by dyspnea, hypoxemia, and respiratory alkalosis mimicking pulmonary thromboembolism. In eight cases with complete interruption of ventilation to an entire lung, chest radiography failed to reveal the extent of the obstruction. Perfusion was substantially less affected than ventilation. Routine ventilation-perfusion scintigraphy with technetium-99m DTPA aerosol aids in the diagnosis of acute major bronchial obstruction in patients with suspected pulmonary thromboembolism. 相似文献
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80.
L. A. Konup I. P. Konup V. E. Sklyar K. N. Kosenko V. P. Gorodnyuk G. V. Fedorova E. I. Nazarov S. A. Kotlyar 《Pharmaceutical Chemistry Journal》1989,23(5):402-408
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 5, pp. 578–583, May, 1989. 相似文献