全文获取类型
收费全文 | 730篇 |
免费 | 37篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 12篇 |
妇产科学 | 17篇 |
基础医学 | 101篇 |
口腔科学 | 41篇 |
临床医学 | 78篇 |
内科学 | 158篇 |
皮肤病学 | 42篇 |
神经病学 | 54篇 |
特种医学 | 20篇 |
外科学 | 56篇 |
综合类 | 37篇 |
预防医学 | 47篇 |
眼科学 | 10篇 |
药学 | 58篇 |
中国医学 | 4篇 |
肿瘤学 | 26篇 |
出版年
2024年 | 1篇 |
2023年 | 11篇 |
2022年 | 35篇 |
2021年 | 43篇 |
2020年 | 21篇 |
2019年 | 29篇 |
2018年 | 33篇 |
2017年 | 18篇 |
2016年 | 17篇 |
2015年 | 17篇 |
2014年 | 40篇 |
2013年 | 39篇 |
2012年 | 59篇 |
2011年 | 52篇 |
2010年 | 36篇 |
2009年 | 18篇 |
2008年 | 49篇 |
2007年 | 40篇 |
2006年 | 27篇 |
2005年 | 25篇 |
2004年 | 39篇 |
2003年 | 26篇 |
2002年 | 26篇 |
2001年 | 7篇 |
2000年 | 9篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 7篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有769条查询结果,搜索用时 15 毫秒
11.
The use of wireless sensor networks (WSN) in healthcare applications is growing in a fast pace. Numerous applications such
as heart rate monitor, blood pressure monitor and endoscopic capsule are already in use. To address the growing use of sensor
technology in this area, a new field known as wireless body area networks (WBAN or simply BAN) has emerged. As most devices
and their applications are wireless in nature, security and privacy concerns are among major areas of concern. Due to direct
involvement of humans also increases the sensitivity. Whether the data gathered from patients or individuals are obtained
with the consent of the person or without it due to the need by the system, misuse or privacy concerns may restrict people
from taking advantage of the full benefits from the system. People may not see these devices safe for daily use. There may
also possibility of serious social unrest due to the fear that such devices may be used for monitoring and tracking individuals
by government agencies or other private organizations. In this paper we discuss these issues and analyze in detail the problems
and their possible measures. 相似文献
12.
Hira PR Assad RM Okasha G Al-Ali FM Iqbal J Mutawali KE Disney RH Hall MJ 《The American journal of tropical medicine and hygiene》2004,70(4):386-389
Myiasis, the invasion of live human tissue by larvae of Diptera, is reported in the nasopharynx and a leg wound in two patients who were hospitalized for more than 72 hours in Mubarak Al-Kabeer Teaching Hospital in Kuwait City, Kuwait. On the fourth and fifth days after a 10-year-old Kuwaiti boy was admitted to the hospital intensive care unit in a bloodied and comatose state following a traffic accident, 'worms' that came out of his nostrils were fixed, cleared, and identified as second and third instar of Lucilia sericata (Diptera: Calliphoridae). After 14 days, 'worms' were seen in the original dressing of a 35-year-old Iranian man admitted to the Orthopedic Unit of the hospital with multiple lacerations and fractures. The larvae, in various stages of development, were identified as those of Megaselia scalaris (Diptera: Phoridae). Since the presence of larvae in both patients was recorded after a stay of at least 3-4 days in the hospital, by definition, these infestations are considered nosocomial. 相似文献
13.
Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster 总被引:3,自引:0,他引:3
Day IN Chen XH Gaunt TR King TH Voropanov A Ye S Rodriguez S Syddall HE Sayer AA Dennison EM Tabassum F Barker DJ Cooper C Phillips DI 《The Journal of clinical endocrinology and metabolism》2004,89(11):5569-5576
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on chromosome 17q23 encoding GH, placental lactogens [chorionic somatomammotropins (CSH)], and placental GH variant in relation to fetal and infant growth and phenotypic features of the metabolic syndrome in subjects aged 59-72 yr from Hertfordshire, UK. Allele groups T, D1, and D2 of a locus herein designated CSH1.01 were examined in relation to GH-CSH single nucleotide polymorphisms and to specific phenotypes. Average birth weights were similar for all genotype groups. Men with T alleles were significantly lighter at 1 yr of age, shorter as adults, and had higher blood pressures, fasting insulin (T/T 66% higher than D2/D2) and triglyceride concentrations, and insulin and glucose concentrations during a glucose tolerance test. Birth weight and 1-yr weight associations with metabolic syndrome traits were independent of the CSH1.01 effects. Common diversity in GH-CSH correlates with low 1-yr weight and with features of the metabolic syndrome in later life. GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome. 相似文献
14.
Faiza A. Rashid Sobia Tabassum Mosin S. Khan Hifzur R. Ansari Muhammad Asif Ahmareen K. Sheikh Syed Sameer Aga 《Journal of clinical laboratory analysis》2021,35(2)
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy among other endocrine tumors, and BRAF V600E is a frequent genetic mutation occurring in the disease. Although different molecular techniques, most importantly sequencing has been widely recognized as a gold standard but molecular diagnosis remains an expensive, laborious, and time‐intensive process. Recently, immunohistochemistry (IHC) with anti‐BRAF V600E (VE1) antibody has increased practical utility and implemented clinically for the detection of BRAF V600E mutation. Therefore, the study aimed to evaluate diagnostic accuracy of VE1 IHC for detecting the BRAF V600E mutation frequency and clinical implementation in diagnostic laboratories. In this study, 72 formalin fixed paraffin‐embedded tissues (FFPE) were used to determine the BRAF V600E mutation status using IHC and Sanger sequencing. The mutation was found in 29% and 28% cases using IHC and Sanger sequencing, respectively. Furthermore, the results showed 100% sensitivity, 98.07% specificity, 95.2% positive predictive value, and 100% negative predictive value. Notably, significant associations were found between BRAF V600E status and tumor stage, tumor focality, and extrathyroidal extensions, respectively. VE1 IHC was found to be a highly sensitive, specific, and diagnostically accurate method in this cohort. Therefore, BRAF V600E detection through IHC has been considered as the best tailored technique for routine pathology laboratories. 相似文献
15.
16.
Wadad Sami Mneimneh Muhammad Ameen Ashraf Li Li Osama El‐Kadi Jiang Qian Tipu Nazeer Alida Hayner‐Buchan 《Pathology international》2013,63(1):68-72
Spinal primary dural lymphoma (PDL) is uncommon with a total of 37 previous well‐documented cases reported, including one diagnosed in the authors' institution. More recently we encountered an additional case of spinal PDL that, similarly to our previous case, was grade 1–2 follicular B‐cell PDL. Our two cases were diagnosed over a 3‐year interval in a 72‐year‐old female and a 74‐year‐old male, respectively. An exhaustive literature review on PDL was performed consequently to reveal that: (i) spinal and cerebral sites of involvement by PDL are constantly mutually exclusive; and (ii) unlike cerebral PDL, which is usually of marginal zone B‐cell type, only two of the 38 cases of spinal PDL were diagnosed as such, diffuse large B‐cell lymphoma being the most commonly encountered type in the spine. This divergence infers that, in contrast to the prevailing concept that PDL is a unique disease group, PDL appears to be rather heterogeneous with a difference in predilection of lymphoma type for the anatomical site of dural involvement. Such a site‐specific lymphoma‐type predilection phenomenon, well‐recognized in other organ systems, has not been acknowledged in PDL. This report brings new insights into PDL, and may contribute to a better understanding of nervous system pathophysiology and lymphoma classification. 相似文献
17.
18.
Ahmed S. Bahaj Haddad H. Alkaff Bashair N. Melebari Anwar N. Melebari Suhail I. Sayed Syeddah S. Mujtaba Sherif K. Abdelmonim Saeed A. Alghamdi Fares E. Alghamdi Omar A. Abu Suliman Mohammad A. Alessa Firas R. Abi Sheffah Anas H. Al-Tammas Rajab A. Al-Zahrani Osama A. Marglani John C. Heaphy Osama A. Bawazir Ameen Z. Alherabi 《Saudi medical journal》2020,41(10):1098
Objectives:To evaluate the accuracy and efficacy of fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules, correlating it with the histopathological findings.Methods:A retrospective evaluation of 314 patients was undertaken at a tertiary referral center of King Abdullah Medical City (KAMC), Makkah, Kingdom of Saudi Arabia, between 2010-2019. Patients who presented with thyroid swellings underwent ultrasonography and FNAC. If indicated, surgery was performed. The FNAC findings were compared to the final histopathological reports.Results:The findings for FNAC from our data set of 314 patients showed a sensitivity value of 79.8%, specificity of 82.1%, accuracy of 74.8%, positive predictive value of 74.8%, and negative predictive value of 85.9%.Conclusion:Our study showed that FNAC has high sensitivity and specificity in the initial evaluation of patients with thyroid nodules. When guided by ultrasonography, the accuracy can be markedly improved. Molecular markers once widely available can improve the diagnostic power of FNAC to be no less than the histopathologic evaluation of thyroid tissue. 相似文献
19.
Isabel F. Tresguerres DDS MD PhD Celia Clemente MD PhD Luis Blanco DDS MD PhD Ameen Khraisat BDS PhD Faleh Tamimi DDS PhD Jesús A.F. Tresguerres MD PhD 《Clinical implant dentistry and related research》2012,14(3):395-399
Purpose: The aim of this study was to assess the effect of local melatonin administration on bone osseointegration around implants in rabbit tibiae. Material and Methods: Ten female, 6‐month‐old New Zealand rabbits were randomly divided into two groups: the experimental group, where five rabbits were treated with local application of melatonin (3 mg) to implant sites when placed into the rabbit tibia, and the control group, those who where without additive materials. Four weeks later, animals were sacrificed; tibiae were dissected from soft tissues and fixed in buffered formaldehyde, and then included in methacrylate. Histological sections were performed to be studied under light microscopy and analyzed morphometrically to evaluate the amount of bone to implant contact (BIC), trabecular area density, and cortical area density. One‐way analysis of variance test was used for statistical evaluation. p < .05 was considered to be significant. Results: Histological evaluation showed more trabecular reaction in the melatonin group. Morphometrical analysis showed a statistically significant increase in trabecular BIC in the melatonin group when compared with the control group (24.61% ± 2.87 vs 13.62% ± 1.44; p < .01). Cortical BIC was decreased in the melatonin group, without statistical significance (71.08 ± 3.63 vs 76.28 ± 2.57; p = 0.31). Trabecular area density was increased significantly in the melatonin group (8.68 ± 1.61 vs 4.02 ± 0.36; p < .05). Cortical area density was decreased significantly in the melatonin group (91.31 ± 1.6 vs 95.7 ± 0.5; p < .05). Conclusion: Within the limitation of this animal study, local melatonin application at the time of implant placement might induce more trabecular bone at implant contact and higher trabecular area density. 相似文献