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81.
Teresa Bernal Estefanía V Pardavila Juan Bonastre Isidro Jarque Marcio Borges Joan Bargay Jose Ignacio Ayestarán Josu Insausti Pilar Marcos Victor González-Sanz Pablo Martínez-Camblor Guillermo M Albaiceta 《Critical care (London, England)》2013,17(6):R302
Introduction
Although the survival rates of hematological patients admitted to the ICU are improving, little is known about the long-term outcome. Our objective was to identify factors related to long-term outcome in hematological patients after ICU discharge.Methods
A prospective, observational study was carried out in seven centers in Spain. From an initial sample of 161 hematological patients admitted to one of the participating ICUs during the study period, 62 were discharged alive and followed for a median time of 23 (1 to 54) months. Univariate and multivariate analysis were performed to identify the factors related to long term-survival. Finally, variables that influence the continuation of the scheduled therapy for the hematological disease were studied.Results
Mortality after ICU discharge was 61%, with a median survival of 18 (1 to 54) months. In the multivariate analysis, an Eastern Cooperative Oncology Group score (ECOG) >2 at ICU discharge (Hazard ratio 11.15 (4.626 to 26.872)), relapse of the hematological disease (Hazard ratio 9.738 (3.804 to 24.93)) and discontinuation of the planned treatment for the hematological disease (Hazard ratio 4.349 (1.286 to 14.705)) were independently related to mortality. Absence of stem cell transplantation, high ECOG and high Acute Physiology and Chronic Health Evaluation II (APACHE II) scores decreased the probability of receiving the planned therapy for the hematological malignancy.Conclusions
Both ICU care and post-ICU management determine the long-term outcome of hematological patients who are discharged alive from the ICU. 相似文献82.
Estefanía Herrera-Ramos Marta López-Rodríguez José Juan Ruíz-Hernández Juan Pablo Horcajada Luis Borderías Elisabeth Lerma José Blanquer María Carmen Pérez-González María Isabel García-Laorden Yanira Florido Virginia Mas-Bosch Milagro Montero José María Ferrer Luisa Sorlí Carlos Vilaplana Olga Rajas Marisa Briones Javier Aspa Eduardo López-Granados Jordi Solé-Violán Felipe Rodríguez de Castro Carlos Rodríguez-Gallego 《Critical care (London, England)》2014,18(3):R127
Introduction
Inherited variability in host immune responses influences susceptibility and outcome of Influenza A virus (IAV) infection, but these factors remain largely unknown. Components of the innate immune response may be crucial in the first days of the infection. The collectins surfactant protein (SP)-A1, -A2, and -D and mannose-binding lectin (MBL) neutralize IAV infectivity, although only SP-A2 can establish an efficient neutralization of poorly glycosylated pandemic IAV strains.Methods
We studied the role of polymorphic variants at the genes of MBL (MBL2), SP-A1 (SFTPA1), SP-A2 (SFTPA2), and SP-D (SFTPD) in 93 patients with H1N1 pandemic 2009 (H1N1pdm) infection.Results
Multivariate analysis showed that two frequent SFTPA2 missense alleles (rs1965708-C and rs1059046-A) and the SFTPA2 haplotype 1A0 were associated with a need for mechanical ventilation, acute respiratory failure, and acute respiratory distress syndrome. The SFTPA2 haplotype 1A1 was a protective variant. Kaplan-Meier analysis and Cox regression also showed that diplotypes not containing the 1A1 haplotype were associated with a significantly shorter time to ICU admission in hospitalized patients. In addition, rs1965708-C (P = 0.0007), rs1059046-A (P = 0.0007), and haplotype 1A0 (P = 0.0004) were associated, in a dose-dependent fashion, with lower PaO2/FiO2 ratio, whereas haplotype 1A1 was associated with a higher PaO2/FiO2 ratio (P = 0.001).Conclusions
Our data suggest an effect of genetic variants of SFTPA2 on the severity of H1N1pdm infection and could pave the way for a potential treatment with haplotype-specific (1A1) SP-A2 for future IAV pandemics. 相似文献83.
Basterra-Gortari FJ Beunza JJ Bes-Rastrollo M Toledo E García-López M Martínez-González MA 《Revista espa?ola de cardiología》2011,64(5):424-426
Obesity, and especially morbid obesity, increases the risk of cardiovascular as well as non-cardiovascular diseases. Our objective was to ascertain the trends in morbid obesity in Spain from 1993 to 2006 using representative data from 106,048 participants in the National Health Surveys. An age-adjusted Poisson regression model stratified by sex was fitted using morbid obesity as the dependent variable.An increasing trend in prevalent morbid obesity from 1.8 to 6.1 per thousand participants was found (increase > 200%). Morbid obesity prevalence was higher in women. After adjusting for age, a monotonically increasing prevalence of morbid obesity was apparent for both men and women: the relative increase was 4% per year in women and 12% per year in men. These trends highlight the importance of preventive actions.Full English text available from: www.revespcardiol.org 相似文献
84.
85.
86.
Toledo JB Vanderstichele H Figurski M Aisen PS Petersen RC Weiner MW Jack CR Jagust W Decarli C Toga AW Toledo E Xie SX Lee VM Trojanowski JQ Shaw LM;Alzheimer’s Disease Neuroimaging Initiative 《Acta neuropathologica》2011,122(4):401-413
Previous studies of Aβ plasma as a biomarker for Alzheimer's disease (AD) obtained conflicting results. We here included 715 subjects with baseline Aβ(1-40) and Aβ(1-42) plasma measurement (50% with 4 serial annual measurements): 205 cognitively normal controls (CN), 348 patients mild cognitive impairment (MCI) and 162 with AD. We assessed the factors that modified their concentrations and correlated these values with PIB PET, MRI and tau and Aβ(1-42) measures in cerebrospinal fluid (CSF). Association between Aβ and diagnosis (baseline and prospective) was assessed. A number of health conditions were associated with altered concentrations of plasma Aβ. The effect of age differed according to AD stage. Plasma Aβ(1-42) showed mild correlation with other biomarkers of Aβ pathology and were associated with infarctions in MRI. Longitudinal measurements of Aβ(1-40) and Aβ(1-42) plasma levels showed modest value as a prognostic factor for clinical progression. Our longitudinal study of complementary measures of Aβ pathology (PIB, CSF and plasma Aβ) and other biomarkers in a cohort with an extensive neuropsychological battery is significant because it shows that plasma Aβ measurements have limited value for disease classification and modest value as prognostic factors over the 3-year follow-up. However, with longer follow-up, within subject plasma Aβ measurements could be used as a simple and minimally invasive screen to identify those at increased risk for AD. Our study emphasizes the need for a better understanding of the biology and dynamics of plasma Aβ as well as the need for longer term studies to determine the clinical utility of measuring plasma Aβ. 相似文献
87.
Rangel CM Neto JA Fonseca EM McAlister J Smith BJ 《Anais da Academia Brasileira de Ciências》2011,83(3):801-815
In this study, the geochemical analysis of ten sediment samples collected along the fluvial system of the Estrela River, which flows into the northern portion of Guanabara Bay, shows the presence of anthropogenic impacts in this area. Concentrations of Fe, Mn, Zn, Cu, Pb, Cr and Ni obtained were slightly higher, when compared with values found in natural environments. The particle size and organic matter content in most of the analyzed stations showed features not conducive to the accumulation of pollutants due to the low organic matter content and the strong presence of sand fraction. There was also the fractionation of heavy metals in sediments and it was found the prominence of residual and reducible phase, besides the significant occurrence of organic fractions in some analyzed stations. These factors, thus, highlight the potential risks of contamination, where the metals associated with the organic phase can become bioavailable in processes of dissolution, provided by physico-chemical changes that can occur in this aquatic environment. 相似文献
88.
Sologuren I Boisson-Dupuis S Pestano J Vincent QB Fernández-Pérez L Chapgier A Cárdenes M Feinberg J García-Laorden MI Picard C Santiago E Kong X Jannière L Colino E Herrera-Ramos E Francés A Navarrete C Blanche S Faria E Remiszewski P Cordeiro A Freeman A Holland S Abarca K Valerón-Lemaur M Gonçalo-Marques J Silveira L García-Castellano JM Caminero J Pérez-Arellano JL Bustamante J Abel L Casanova JL Rodríguez-Gallego C 《Human molecular genetics》2011,20(8):1509-1523
We report a series of 14 patients from 11 kindreds with recessive partial (RP)-interferon (IFN)-γR1 deficiency. The I87T mutation was found in nine homozygous patients from Chile, Portugal and Poland, and the V63G mutation was found in five homozygous patients from the Canary Islands. Founder effects accounted for the recurrence of both mutations. The most recent common ancestors of the patients with the I87T and V63G mutations probably lived 1600 (875-2950) and 500 (200-1275) years ago, respectively. The two alleles confer phenotypes that are similar but differ in terms of IFN-γR1 levels and residual response to IFN-γ. The patients suffered from bacillus Calmette-Guérin-osis (n= 6), environmental mycobacteriosis (n= 6) or tuberculosis (n= 1). One patient did not suffer from mycobacterial infections but had disseminated salmonellosis, which was also present in two other patients. Age at onset of the first environmental mycobacterial disease differed widely between patients, with a mean value of 11.25 ± 9.13 years. Thirteen patients survived until the age of 14.82 ± 11.2 years, and one patient died at the age of 7 years, 9 days after the diagnosis of long-term Mycobacterium avium infection and the initiation of antimycobacterial treatment. Up to 10 patients are currently free of infection with no prophylaxis. The clinical heterogeneity of the 14 patients was not clearly related to either IFNGR1 genotype or the resulting cellular phenotype. RP-IFN-γR1 deficiency is, thus, more common than initially thought and should be considered in both children and adults with mild or severe mycobacterial diseases. 相似文献
89.
Martín-Loeches I Solé-Violán J Rodríguez de Castro F García-Laorden MI Borderías L Blanquer J Rajas O Briones ML Aspa J Herrera-Ramos E Marcos-Ramos JA Sologuren I González-Quevedo N Ferrer-Agüero JM Noda J Rodríguez-Gallego C 《Intensive care medicine》2012,38(2):256-262
Purpose
Conflicting results about the role of genetic variability at IL6, particularly the -174 G/C single nucleotide polymorphism (SNP), in sepsis have been reported. We studied the genetic variability at IL6 in patients with community-acquired pneumonia (CAP) and pneumococcal CAP (P-CAP).Methods
This was a multicenter, prospective observational study. IL6 -174 was analyzed in 1,227 white Spanish patients with CAP (306 with P-CAP). IL6 1753 C/G (N?=?750), 2954 G/C (N?=?845), and haplotypes defined by these SNPs were also studied.Results
In CAP patients the genotype -174 GG were associated with protection against acute respiratory distress syndrome (ARDS) (p?=?0.008, OR?=?0.4, 95% CI 0.2?C0.8). No other significant associations were observed. However, in patients with P-CAP multivariate analysis adjusted for age, gender, co-morbidity, hospital of origin, and severity (pneumonia severity index, PSI) showed that the IL6 -174 GG genotype was protective against the development of ARDS (p?=?0.002, OR?=?0.25, 95% CI 0.07?C0.79), septic shock (p?=?0.006, OR?=?0.46, 95% CI 0.18?C0.79), and multiple organ dysfunction syndrome (p?=?0.02, OR?=?0.53, 95% CI 0.27?C0.89). P-CAP patients homozygous for IL6 -174 G also showed a higher survival in a logistic regression analysis adjusted for age, gender, co-morbidity, hospital of origin, and PSI (p?=?0.048, OR?=?0.27, 95% CI 0.07?C0.98).Conclusions
Our results indicate that the IL-6 -174 GG genotype is associated with lower severity and mortality in patients with P-CAP. This effect was higher than that observed in patients with CAP irrespective of the causal pathogen involved. Our results highlight the importance of the causal pathogen in genetic epidemiological studies in sepsis. 相似文献90.
Itziar Zazpe Ramón Estruch Estefanía Toledo Ana Sánchez-Taínta Dolores Corella Mónica Bulló Miquel Fiol Pablo Iglesias Enrique Gómez-Gracia Fernando Arós Emilio Ros Helmut Schröder Lluis Serra-Majem Xavier Pintó Rosa Lamuela-Raventós Valentina Ruiz-Gutiérrez Miguel Ángel Martínez-González 《European journal of nutrition》2010,49(2):91-99