全文获取类型
收费全文 | 431篇 |
免费 | 42篇 |
国内免费 | 4篇 |
专业分类
儿科学 | 38篇 |
妇产科学 | 2篇 |
基础医学 | 34篇 |
口腔科学 | 12篇 |
临床医学 | 26篇 |
内科学 | 83篇 |
皮肤病学 | 5篇 |
神经病学 | 4篇 |
特种医学 | 51篇 |
外科学 | 69篇 |
综合类 | 12篇 |
预防医学 | 23篇 |
眼科学 | 57篇 |
药学 | 19篇 |
肿瘤学 | 42篇 |
出版年
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 8篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 12篇 |
2014年 | 21篇 |
2013年 | 13篇 |
2012年 | 7篇 |
2011年 | 10篇 |
2010年 | 14篇 |
2009年 | 25篇 |
2008年 | 15篇 |
2007年 | 17篇 |
2006年 | 21篇 |
2005年 | 15篇 |
2004年 | 9篇 |
2003年 | 18篇 |
2002年 | 15篇 |
2001年 | 16篇 |
2000年 | 9篇 |
1999年 | 6篇 |
1998年 | 21篇 |
1997年 | 28篇 |
1996年 | 28篇 |
1995年 | 17篇 |
1994年 | 26篇 |
1993年 | 16篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1976年 | 5篇 |
排序方式: 共有477条查询结果,搜索用时 629 毫秒
471.
472.
473.
Hering J Garrean S Saied A Helton WS Espat NJ 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2007,9(4):319-323
Background. Control of intraoperative hemorrhage represents a significant challenge in hepatic surgery, particularly during resection of large, hypervascular hepatic hemangiomata (HH). Various devices to minimize blood loss from hepatic parenchymal transection are currently under investigation. Herein, we present our experience with a radiofrequency (RF)-powered multiarray for resection of HH. Patients and methods. From September 2005 to January 2006, we conducted a retrospective review of our hepatobiliary database to identify patients with symptomatic giant cavernous HH undergoing resection with a RF multiarray device. The purpose of this review was to assess the technical aspects of using RF energy to assist in the resection of HH. Results. The extent of operation varied depending on the size and location of the tumor. Two patients underwent two atypical subsectionectomies and two underwent trisectionectomies. The Habib™ sealer provided a safe and effective method for hepatic parenchymal transaction. No patients required blood transfusion, and no injuries to major biliary or vascular strictures were observed at 1 year follow-up. A seroma developed in one patient 6 months postoperatively, but was drained percutaneously. Conclusions.Hepatic parenchymal transection with the Habib sealer device is a feasible approach to resect HH. Further study is needed to objectively compare the efficacy of RF-assisted parenchymal transection with that of traditional parenchymal transection techniques. 相似文献
474.
475.
Hering J Garrean S Dekoj TR Razzak A Saied A Trevino J Babcock TA Espat NJ 《Annals of surgical oncology》2007,14(12):3620-3628
Background Pancreatic cancer-gemcitabine (GEM) chemoresistance has been demonstrated to be associated with enhanced NF-kB activation
and antiapoptotic protein synthesis. The well-known capacity of omega-3 fatty acids (n-3 FAs) to inhibit NF-kB activation
and promote cellular apoptosis has the potential to restore or facilitate gemcitabine chemosensitivity.
Methods Four pancreatic cancer cell lines (MIA PaCa-2, BxPC-3, PANC-1, and L3.6), each with distinct basal NF-kB and differing GEM
sensitivity profiles, were administered: 100 uM of (1) n-3FA, (2) n-6FA, (3) GEM, (4) n-3FA + GEM, or (5) n-6FA + GEM for
24 and 48 hours. Proliferation was assessed using the WST-1 assay. To define the mechanism(s) of altered proliferation, electron
mobility shift assay for NF-kB activity, western blots of phoshoStat3, phosphoIκB, and poly(ADP-ribose) polymerase (PARP)
cleavage were performed in the MIA PaCa-2 cell line.
Results All cell lines demonstrated a time/dose-dependent inhibition of proliferation in response to n-3FA. For MIA PaCa-2 cells,
n-3FA and n-3FA + GEM treatment resulted in reduction of I-kB phosphorylation and NF-kB activation when compared with n-6FA
control. n-3FA and combination treatment also significantly decreased Stat3 phosphorylation, whereas GEM alone had no effect.
n-3FAs and n-3FA + GEM groups demonstrated increased PARP cleavage, mirroring NF-kB activity and Stat3 phosphorylation.
Conclusions n-3 FA treatment is specifically associated with inhibition of proliferation in these four pancreatic cell lines irrespective
of varied gemcitabine resistance. An experimental paradigm to screen for potential contributory mechanism(s) in altered pancreatic
cancer cellular proliferation was defined, and using this approach the co-administration of n-3 FA with GEM inhibited GEM-induced
NF-kB activation and restored apoptosis in the MIA PaCa-2 cell-line.
Supported
by: NIDDK K08 DK DK60778 (Espat) 相似文献
476.
Andrew F Riley MBChB Christina N Grupcheva MD Tahira Y Malik FRCOphth Jennifer P Craig PhD Charles NJ McGhee PhDFRANZCO 《Clinical & experimental ophthalmology》2001,29(6):381-386
Purpose : To determine patient demographics and the ocular biometric parameters in patients presenting for cataract surgery within the public hospital system, in a defined New Zealand population. Method : Prospective study of 502 eyes of 488 consecutive patients undergoing cataract surgery. A clinical assessment, including refraction, keratometry (K), A‐scan ultrasound and Orbscan II computerized topography was performed on each eye. Results : The mean age of the group was 74.9 ± 9.8 years (mean ± SD) with a female predominance (62%). Ethnic origin included 72% European, 8% Maori, 10% Pacific Islander, 4% Asian, 3% Indian and 3% other ethnic origins. The mean Log MAR visual acuity of eyes prior to cataract surgery was 0.88 ± 0.57 (approximately 6/48–1). Corneal topographic (keratometric) maps were classified into five groups: 34% round, 10% oval, 31% symmetrical bow tie, 12% asymmetrical bow tie and 13% irregular. The mean steepest K measurement was 44.1 ± 1.7 D, the median keratometric astigmatism 0.89 D (range 0.0–6.5 D) and the steepest corneal meridian was horizontal in 50% and vertical in 43%. Seven per cent of corneas were spherical. Refraction revealed a mean sphere of 0.0 ± 3.1 D and a mean cylinder of –1.2 (range 0.0–7.5 D). Refractive astigmatism was with‐the‐rule in 15%, against‐the‐rule in 50% and oblique in 15%, with 20% spherical. Axial length was a mean of 23.14 ± 1.03 mm. Conclusion : Patients presenting for cataract surgery in this study were predominantly elderly, female, of European Caucasian ethnicity and exhibited relatively poor corrected visual acuity in the affected eye. Interestingly, 41% of eyes demonstrated bow‐tie topographic patterns, largely exhibiting with‐the‐rule astigmatism. However, assessment by keratometry or refraction highlighted against‐the‐rule more frequently; this may have implications for combined cataract and astigmatic surgery. The mean axial length was slightly shorter than expected for a group of predominantly European ethnic origin, although the mean refractive error was emmetropic. 相似文献
477.