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D. A. MacFadyen Ernest Sturm James B. Murphy 《The Journal of experimental medicine》1939,70(5):475-483
1. Mammary tissue of pregnant rabbits is found to contain an agent which inhibits the growth of Bashford Adenocarcinoma 63 in mice but this material is without effect on the Crocker Sarcoma 180. 2. Of the tissues so far studied the mammary gland of rabbits has yielded the most active product. 3. From the results it is probable that pregnancy enhances the production of the agent but this cannot be considered as established beyond doubt. 4. The factor is found, with diminished activity, only in the protein fraction obtained from the aqueous extract by full saturation with ammonium sulfate. 相似文献
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Proposed Report on the Educational Qualifications of Sanitarians. Committe on Professional Education
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Ernest H. Latham 《American journal of surgery》1946,72(1):114-117
To summarize this subject of embryoma of the kidney which unfortunately carries such a poor prognosis, one usually has to deal with a somewhat pale, fretful, young child running a silent, painless, symptomless course finally coming for a check-up, or because of an accidently discovered abdominal mass whose surface is smooth but nodular and extending one-half to two-thirds down one or other of the flanks. The differential diagnosis is briefly considered and the treatment of preoperative irradiation followed by surgical excision discussed.An almost classical text book type of case is reported; however, the usually fatal outcome came a little more abruptly than was anticipated and was thought, because of the operative finding, to be due to massive metastatic pulmonary embolus. The treatment with no evidence of metastasis is nephrectomy with or without preoperative irradiation, the latter still somewhat of a moot pointEmbryoma of the kidney carries a grave prognosis, death within a few years at best. 相似文献
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1. The present paper constitutes a preliminary study of the morphology of mitochondria by means of electron microscopy. 2. The mitochondria that were the subject of this investigation were obtained from a lymphosarcoma of the rat. They were separated from the other components of the leukemic cells by a method of differential centrifugation, and thus made available for direct examination in the electron microscope. 3. In the purified form the mitochondria appeared as spherical bodies, the majority of them varying in size approximately from 0.6 to 1.3 µ in diameter. 4. Certain aspects of mitochondria in the electron microscope suggest that these elements are surrounded by a differentiated membrane. In some cases the limiting membrane seemed to be responsible for maintaining the general shape of the mitochondria, even when most of the mitochondrial substance had been lost. 5. By means of the electron microscope, it is possible to distinguish small elements, 80 to 100 mµ in diameter, within the body of certain mitochondria. Further work is suggested to establish whether these small granules are normal constituents of mitochondria, and what relation may exist between them and ordinary microsomes. 6. The nature of mitochondria as morphological units is discussed. Present evidence indicates that mitochondria constitute definite physical entities which can persist in the absence of the cytoplasm. 相似文献
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