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131.
Carmelo Urso Lorenzo Borgognoni Morena Doria Galliano Tinacci and Enzo Zini 《Journal of cutaneous pathology》2009,36(5):586-590
We report a 20-year-old male patient with an atypical Spitz tumor, located in the dorsal aspect of his left hand, and a positive sentinel axillary lymph node. After lymphadenectomy, 1 of 23 non-sentinel lymph nodes excised was found to contain small multiple deposits of large spindle atypical melanocytes. Reviewing the pertinent literature, 5 of 29 patients with atypical Spitz tumors and positive sentinel nodes who had undergone lymphadenectomy have shown non-sentinel node involvement (17.2%), a proportion similar to that reported in melanoma patients. The exact nature of atypical Spitz tumors and the interpretation of cell deposits detected in sentinel nodes are still debated; data regarding the non-sentinel lymph node involvement in patients with atypical Spitz tumors may contribute to better understand the real biological potential of such tumors. 相似文献
132.
Falcone C Campo I Emanuele E Buzzi MP Geroldi D Belvito C Zorzetto M Sbarsi I Cuccia M 《Clinica chimica acta; international journal of clinical chemistry》2005,354(1-2):111-116
BACKGROUND: We have recently reported that homozygosity for the minor A-allele of RAGE (receptor for advanced glycation end products) -374T/A polymorphism may exert a protective effect toward the development of angiographic coronary artery disease (CAD). Here we focused on the putative involvement of this functional RAGE polymorphism on the severity of coronary atherosclerosis as assessed by angiography. METHODS: In a total of 234 consecutive Caucasian patients with angiographically proven CAD, the severity of coronary atherosclerosis was assessed by the number of diseased vessels (greater than 50% stenosis). Genotyping for the -374T/A variant was performed by means of PCR-RFLPs. RESULTS: The mean number of diseased vessels was significantly lower in patients with the AA genotype (1.47+/-0.68) than in those with the AT or TT genotype (1.88+/-0.82, p=0.029). After confounding variables were controlled for, the number of diseased vessels remained significantly different in the AA genotype carriers from that in the AT or TT carriers (p=0.041, ANCOVA). CONCLUSIONS: Our data suggest that the RAGE -374T/A polymorphism is one of the likely candidate determinants for the genetic variance of disease phenotype in coronary atherosclerosis. 相似文献
133.
134.
Magnetic resonance imaging in a large cohort of facioscapulohumeral muscular dystrophy patients: Pattern refinement and implications for clinical trials
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135.
136.
Brekalo Z Innocenti P Duzel G Liddo G Ballone E Simunović VJ 《Wiener klinische Wochenschrift》2007,119(23-24):722-728
OBJECTIVE: To compare the specific features and outcomes of laparoscopic cholecystectomy in two university hospitals, one in a developing country, Bosnia-Herzegovina, and the other in a well developed country, Italy. METHODS: Between January 1996 and December 2005, a total of 2018 patients underwent laparoscopic cholecystectomy in Mostar Clinical Hospital, Bosnia-Herzegovina (1066) and in Chieti University Hospital, Chieti, Italy (952). Differences in patients' presentations, diagnostic protocols, medication, surgical treatment, complications and outcomes were analyzed. RESULTS: The number of patients with life-threatening conditions was lower in Italy (15 or 1.5% vs. 53 or 4.9%; P<0.001), as was the use of analgesia and antibiotics (131 or 13.96% vs. 873 or 81.97%; P<0.001). Open-access biliary surgery was rare in Italy, where the vast majority of patients were operated laparoscopically; only 44 (4.41%) patients had open-access surgery, including 35 (3.61%) conversion patients. In comparison, 1669 (61%) patients in Bosnia-Herzegovina underwent open-access operations. There was a significant difference, in favor of the Italian hospital, in the number of surgical complications (8 or 0.84% vs. 40 or 3.75%; P<0.002) and also in the number of postoperative infections following surgical incision (0 or 0.0% vs. 6 or 0.56%; P<0.033). CONCLUSIONS: It is encouraging for surgeons in Bosnia-Herzegovina to find that satisfactory results can be achieved in a developing country. However, the number of complications encountered in the Mostar hospital emphasizes the need for further improvement of surgical technique through better structured training combined with strict supervision of junior staff. The finding of postoperative infections in the Bosnia-Herzegovina hospital, despite that their occurrence was relatively rare, highlights the necessity for further improvement of hospital infection control. 相似文献
137.
Fabrizia Bamonti Cristina Novembrino Silvia Ippolito Enzo Soresi Alberto Ciani Silvia Lonati Elisabetta Scurati-Manzoni Giuliana Cighetti 《Clinical chemistry and laboratory medicine》2006,44(4):391-395
Background: Cigarette smoking, a cardiovascular risk factor leading to oxygen free radical formation, is involved in the development of serious pathological conditions. On the other hand, a healthy diet and adequate supplementation can help prevent many diseases. The aim of our study was to evaluate in healthy light smokers the effects of supplementation with mixed fruit and vegetable juice powder concentrate on homocysteine metabolism and oxidative status. Methods: In this pilot study, 32 healthy volunteers, 16 light smokers and 16 non-smokers, on twice daily supplementation were monitored at time zero and after 30 days. Plasma homocysteine, and serum vitamin B(12) and folate concentrations were measured by immunoenzymatic assays; reactive oxygen species, total antioxidant capacity and thiol groups by spectrophotometric methods; and total and free malondialdehyde concentrations by gas chromatography-mass spectrometry with isotopic dilution. Results: Baseline free malondialdehyde concentrations were significantly higher in smokers than in non-smokers and normalised after 30-day supplementation. Baseline results for all the other parameters remained unchanged after supplementation, with no significant differences between smokers and non-smokers. Conclusion: This is the first study showing a significant decrease in free malondialdehyde levels in light smokers after 1-month phytonutrient supplementation. 相似文献
138.
De Conti F Piovesana P Nicolosi G Lafisca N Mantovani E Viena P Pantaleoni A 《Echocardiography (Mount Kisco, N.Y.)》1997,14(4):387-392
Systolic anterior motion of the mitral valve (MV) with dynamic left ventricular (LV) outflow tract obstruction is a well known phenomenon in hypertrophic cardiomyopathy, or other forms of hyper-dynamic LV function associated with hypovolemic states, or LV hypertrophy. We report three patients with MV prolapse in the absence of the above predisposing factors, who developed an LV outflow dynamic gradient during acute transient myocardial ischemia. An interaction between structural abnormalities of the mitral apparatus and ischemia-dependent LV shape deformity most likely accounted for the outflow gradient. 相似文献
139.
Enzo Bonora Stefano Orioli Carlo Coscelli Giampiero Buzzelli Paolo Gentilini Ugo Butturini 《Acta diabetologica》1984,21(3):241-250
Summary In the present investigation, insulin sensitivity and fasting levels of insulin, C-peptide, glucagon, growth hormone and free
fatty acids were estimated and correlated in a population of individuals suffering from liver cirrhosis or chronic hepatitis.
Insulin sensitivity, assessed by glucose disappearance rate after intravenous bolus injection of insulin, was reduced but
not significantly different from controls in subjects with chronic persistent hepatitis, while it was significantly reduced
in individuals suffering from chronic active hepatitis or liver cirrhosis. Insulin, glucagon, growth hormone, and free fatty
acid fasting levels were higher than in healthy subjects in individuals with liver cirrhosis or chronic active hepatitis but
not in subjects with chronic persistent hepatitis. C-peptide concentrations did not differ from controls in subjects with
liver disease. Significant negative correlations occurred between coefficients of insulin sensitivity and fasting concentrations
of insulin, glucagon, growth hormone and free fatty acids, but not with fasting levels of C-peptide. Positive relationships
were present between fasting levels of free fatty acids and both glucagon and growth hormone concentrations. These results
show that, unlike subjects with liver cirrhosis and chronic active hepatitis, individuals suffering from chronic persistent
hepatitis do not differ from healthy subjects in insulin sensitivity and fasting levels of insulin, glucagon, growth hormone,
and free fatty acids. Moreover, they suggest that both hyperinsulinemia and high concentrations of counterregulatory substances
might play a role in the pathogenesis of insulin resistance in subjects suffering from chronic liver disease.
Supported by grants from the Ministry of Public Education and grant No. 83/02132.04 from the National Research Council (C.N.R.),
Rome. 相似文献
140.