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排序方式: 共有568条查询结果,搜索用时 15 毫秒
81.
Lucia Marseglia Gabriella D'Angelo Pietro Impellizzeri Vincenzo Salvo Natalia Catalano Rocco Bruno Claudio Galletti Bruno Galletti Francesco Galletti Eloisa Gitto 《Pediatrics international》2017,59(1):115-117
Neonatal stridor is a rare condition usually caused by laryngomalacia. Congenital laryngeal cyst represents an uncommon cause of stridor in the neonatal population and may be misinterpreted as laryngomalacia, leading to serious morbidity and mortality if diagnosis and treatment are delayed. Herein we report the case of a full‐term infant with stridor, feeding problems and failure to thrive. Initially, direct laryngoscopy diagnosed only laryngomalacia. As stridor worsened, however, and respiratory distress appeared, repeat laryngoscopy showed vallecular laryngeal cyst, visible macroscopically. The patient was successfully treated with endoscopic marsupialization. There was no evidence of recurrence at follow up after 3 months. This case highlights the importance of laryngoscopic assessment for suspected laryngeal abnormalities in infants with stridor. If symptoms worsen, endoscopy should be repeated, because congenital laryngeal cysts may not be immediately visible macroscopically. 相似文献
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Catzin-Kuhlmann A Castillo-Martínez L Colín-Ramírez E Valles V Aguilar-Salinas CA Sierra J Calva JJ 《Archives of medical research》2008,39(1):84-91
BACKGROUND: There is a need to assess whether human immunodeficiency virus (HIV)-infected patients are more likely than noninfected individuals to have any of the specific lipoprotein combination profiles identified as the best predictors of future cardiovascular disease in the general population. METHODS: One hundred five infected patients, randomly selected from a Mexican HIV clinic, and 105 age- and gender-matched noninfected community volunteers, were enrolled to study the prevalence of each of three highly atherogenic lipoprotein phenotypes [high apolipoprotein (Apo)B/ApoA-I ratio, hypertriglyceridemia with high ApoB and hypoalphalipoproteinemia with high ApoB], and the relationship between time of exposure to antiretroviral therapy (ART) drug class and lipid changes. RESULTS: The highly atherogenic lipoprotein phenotypes were similarly frequent in both groups. There was a nonsignificant increased risk of dyslipidemia with longer exposure to any of the ART drug classes, although this hazard seems to be greater in patients with central fat accumulation. CONCLUSIONS: No evidence of increased risk for certain highly atherogenic lipoprotein phenotypes in HIV-infected patients was found. More than one pathogenic mechanism for ART-associated dyslipidemia is postulated. 相似文献
84.
Mine Arslan-Kirchner Eloisa Arbustini Catherine Boileau Philippe Charron Anne H Child Gwenaelle Collod-Beroud Julie De Backer Anne De Paepe Anna Dierking Laurence Faivre Sabine Hoffjan Guillaume Jondeau Britta Keyser Bart Loeys Karin Mayer Peter N Robinson J?rg Schmidtke 《European journal of human genetics : EJHG》2016,24(1):146-150
85.
Laura Obici Vittorio Bellotti Palma Mangione Monica Stoppini Eloisa Arbustini Laura Verga Irene Zorzoli Ernesto Anesi Giuseppe Zanotti Carlo Campana Mario Vigan Giampaolo Merlini 《The American journal of pathology》1999,155(3):695-702
We identified a novel missense mutation in the apolipoprotein A-I gene, T2069C Leu(174) --> Ser, in a patient affected by familial systemic nonneuropathic amyloidosis. The amyloid deposits mostly affected the heart of the proband, who underwent transplantation for end-stage congestive heart failure. Amyloid fibrils of myocardial and periumbilical fat samples immunoreacted exclusively with anti-ApoA-I antibodies. Amyloid fibrils extracted from the heart were constituted, according to amino acid sequencing and mass spectrometry analysis, by an amino-terminal polypeptide ending at Val(93) of apolipoprotein A-I (apoA-I); no other significant fragments were detected. The mutation segregates with the disease; it was demonstrated in the proband and in an affected uncle and excluded in three healthy siblings. The plasma levels of high-density lipoprotein and apoA-I were significantly lower in the patient than in unaffected individuals. This represents the first case of familial apoA-I amyloidosis in which the mutation is outside the polypeptide fragment deposited as fibrils. Visualization of the mutation in the three-dimensional structure of lipid-free apoA-I, composed of four identical polypeptide chains, indicates that position 174 of one chain is located near position 93 of an adjacent chain and suggests that the amino acid replacement in position 174 is permissive for a proteolytic split at the C-terminal of Val(93). 相似文献
86.
Tomioka Renato B. Ferreira Gabriela R. V. Aikawa Nadia E. Maciel Gustavo A. R. Serafini Paulo C. Sallum Adriana M. Campos Lucia M. A. Goldestein-Schainberg Claudia Bonfá Eloisa Silva Clovis A. 《Clinical rheumatology》2018,37(10):2869-2873
Clinical Rheumatology - To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs... 相似文献
87.
Juliana Barbosa Brunelli Ana Renata Schmidt Adriana Maluf Elias Sallum Claudia Goldenstein-Schainberg Eloisa Bonfá Clovis A. Silva 《Modern rheumatology / the Japan Rheumatism Association》2018,28(2):264-270
Objectives: To assess the rate of serious and/or opportunistic infections in juvenile idiopathic arthritis (JIA) patients from a single tertiary center under biologic therapy and to identify possible risk factors associated to these complications.Methods: A total of 107 JIA patients followed at the biologic therapy center of our tertiary university hospital using a standardized electronic database protocol including demographic data, clinical and laboratorial findings and treatment at baseline and at the moment of infection. Opportunistic infections included tuberculosis, herpes zoster and systemic mycosis.Results: A total of 398 patient-yrs(py) were included. The median time of biologic exposure was 3.0 years (0.15–11.5). We observed 35 serious/opportunistic infectious events in 27 (25%) patients: 31(88.6%) were serious infections and four (11.4%) opportunistic infections. Serious/opportunistic infections rates were 10.6/100py for ETN, 10.9/100py for ADA, 2.6/100py for ABA and 14.8/100py for TCZ. Comparison of 27 patients with and 80 without infection showed a higher frequency of systemic-onset JIA, lower age at biologic therapy initiation and a history of previous serious infection (p?.05) in the former group.Conclusions: This study demonstrated a high rate of serious infections in JIA patients under biologic therapy in a real-life setting. Systemic-onset JIA, lower age at biologic therapy start and history of previous serious infections were important risk factors for these complications. Also, higher rates of severe infections comparing to the former studies was possibly due to elevated MTX doses in our patients. 相似文献
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Francesco Giudici Letizia Lombardelli Edda Russo Tiziana Cavalli Daniela Zambonin Federica Logiodice Ornela Kullolli Lamberto Giusti Tatiana Bargellini Marilena Fazi Livia Biancone Stefano Scaringi Ann Maria Clemente Eloisa Perissi Giovanni Delfino Maria G Torcia Ferdinando Ficari Francesco Tonelli Marie-Pierre Piccinni Cecilia Malentacchi 《World Journal of Clinical Cases》2019,7(17):2463-2476