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Ishiguro A; Spirin KS; Shiohara M; Tobler A; Gombart AF; Israel MA; Norton JD; Koeffler HP 《Blood》1996,87(12):5225-5231
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Spread of X inactivation on chromosome 15 is associated with a more severe phenotype in a girl with an unbalanced t(X; 15) translocation
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Lim M. S. Beyer Thomas Babayan A. Bergmann M. Brehme M. Buyx A. Czernin J. Egger G. Elenitoba-Johnson K. S. J. Gückel B. Jačan A. Haslacher H. Hicks R. J. Kenner L. Langanke M. Mitterhauser M. Pichler B. J. Salih H. R. Schibli R. Schulz S. Simecek J. Simon J. Soares M. O. Stelzl U. Wadsak W. Zatloukal K. Zeitlinger M. Hacker M. 《Molecular imaging and biology》2020,22(1):47-65
Molecular Imaging and Biology - Here, we report on the outcome of the 2nd International Danube Symposium on advanced biomarker development that was held in Vienna, Austria, in early 2018. During... 相似文献
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Expression of Skp2, a p27(Kip1) ubiquitin ligase,in malignant lymphoma: correlation with p27(Kip1) and proliferation index 总被引:24,自引:0,他引:24
Lim MS Adamson A Lin Z Perez-Ordonez B Jordan RC Tripp S Perkins SL Elenitoba-Johnson KS 《Blood》2002,100(8):2950-2956
Reduced levels of p27(Kip1) are frequent in human cancers and have been associated with poor prognosis. Skp2, a component of the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complex, has been implicated in p27(Kip1) degradation. Increased Skp2 levels are seen in some solid tumors and are associated with reduced p27(Kip1). We examined the expression of these proteins using single and double immunolabeling in a large series of lymphomas to determine if alterations in their relative levels are associated with changes in cell proliferation and lymphoma subgroups. We studied the expression of Skp2 in low-grade and aggressive B-cell lymphomas (n = 86) and compared them with p27(Kip1) and the proliferation index (PI). Fifteen hematopoietic cell lines and peripheral blood lymphocytes were studied by Western blot analysis. In reactive tonsils, Skp2 expression was limited to proliferating germinal center and interfollicular cells. Skp2 expression in small lymphocytic lymphomas (SLLs) and follicular lymphomas (FCLs) was low (mean percentage of positive tumor cells, less than 20%) and was inversely correlated (r = -0.67; P <.0001) with p27(Kip1) and positively correlated with the PI (r = 0.82; P <.005). By contrast, whereas most mantle cell lymphomas (MCLs) demonstrated low expression of p27(Kip1) and Skp2, a subset (n = 6) expressed high Skp2 (exceeding 20%) with a high PI (exceeding 50%). Skp2 expression was highest in diffuse large B-cell lymphomas (DLBCLs) (mean, 22%) and correlated with Ki-67 (r = 0.55; P <.005) but not with p27(Kip1). Cytoplasmic Skp2 was seen in a subset of aggressive lymphomas. Our data provide evidence for p27(Kip1) degradative function of Skp2 in low-grade lymphomas. The absence of this relationship in aggressive lymphomas suggests that other factors contribute to deregulation of p27(Kip1) expression in these tumors. 相似文献
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腺病毒载体介导的PML生长抑制因子对前列腺癌细胞生长和致瘤能力的抑制效果 总被引:1,自引:0,他引:1
为探讨用腺病毒载体携带PML(PromyelocyticLeukemia)基因作为前列腺癌基因治疗的可能性,应用重组人携带PML基因腺病毒(AdPML)感染培养的前列腺癌细胞,观察表达PML蛋白的癌细胞与对照组癌细胞的体外生长和裸鼠体内致瘤能力变化,对荷瘤裸鼠瘤体周围注射AdPML,观察治疗组和对照组肿瘤生长的变化。结果显示,感染AdPML的前列腺癌细胞体外生长和裸鼠体内致瘤能力明显下降,荷瘤裸鼠瘤体周围注射AdPML后肿瘤生长速度明显减慢。证实了PML是一种生长抑制因子,提示其可能被应用于前列腺癌的基因治疗研究 相似文献
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