FGF18 as a potential biomarker in serous and mucinous ovarian tumors

Tumor Biology - Fibroblast growth factor 18 (FGF18) has been suggested to play important roles in promoting progression of ovarian high-grade serous carcinoma. Our aim was to investigate FGF18...     

乳腺癌各分子亚型中骨桥蛋白的表达及其临床意义

目的： 研究骨桥蛋白（osteopontin,OPN）在乳腺癌各分子亚型中的表达及其临床意义。 方法： 收集2000年1月至2003年12 月第二军医大学长海医院的99例乳腺癌组织标本,免疫组织化学法检测ER（estrogen receptor）、PR(progesterone receptor)和HER-2（human epidermal growth factor receptor-2）的表达,并据此将乳腺癌患者分为luminal A型、luminal B型、HER-2过表达型和基底细胞样型。免疫组织化学法测定各分子亚型乳腺癌组织中OPN的表达情况,并分析OPN表达与乳腺癌患者临床病理特征的关系。 结果： 根据ER、PR和HER-2的不同表达情况,99例乳腺癌患者中luminal A型45例、luminal B型27例、HER-2过表达型14例、基底细胞样型13例。OPN在luminal A型、luminal B型、HER-2过表达型和基底细胞样型中表达率分别为22.2%、29.6%、71.4%和61.5%,HER-2过表达型和基底细胞样型乳腺癌组织中OPN表达率均高于luminal A型和luminal B型（P<0.01）。OPN低表达的乳腺癌患者生存率高于OPN高表达者,两者差异有统计学意义（P<0.01）。 结论： OPN在基底细胞样型和HER-2过表达型乳腺癌组织中高表达,其表达可作为乳腺癌预后的评估指标之一。     

Intraarterial digital subtraction arteriographic evaluation of extremity tumors: comparison with conventional arteriography

Conventional arteriography and intraarterial digital subtraction arteriography (IADSA) were compared in 36 patients with primary bone or soft-tissue tumors of the extremities. The sensitivity of IADSA was at least equal to conventional arteriography for demonstrating normal or abnormal major arteries and feeding arteries, equal to or superior for depicting tumor stains or draining veins, but slightly inferior for revealing minute tumor vessels. An increase of the matrix size from 256 X 256 to 512 X 512 improved these sensitivities. IADSA with 15% diatrizoate contrast material eliminated the contrast material-induced pain in all patients. With a computer-controlled iris setting, an average of 5 minutes of procedure time and 1.7 R of radiation (0.44 mC kg) per examination could be saved. IADSA reduced the cost of an examination by an average of $67. The results indicate that IADSA was diagnostic in all instances and can replace conventional arteriography for the evaluation of extremity tumors.     

Reactive arthritis due to Salmonella enteritidis complicated by carditis

Reactive arthritis following infection with enteropathogenic bacteria is usually a self-limiting disease that disappears after a few months without sequela. We describe two girls who developed carditis shortly after the onset of reactive arthritis due to infection with Salmonella enteritidis. The carditis presented with fatigue and arrhythmia and involved the aortic valve in both patients leading to definite aortic regurgitation in one. A similar pattern of cardiac involvement is found in other spondyloarthropathies, including Reiter's syndrome and ankylosing spondylitis. We conclude that Salmonella reactive arthritis may be complicated by carditis.