全文获取类型
收费全文 | 245篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 13篇 |
妇产科学 | 9篇 |
基础医学 | 26篇 |
口腔科学 | 6篇 |
临床医学 | 22篇 |
内科学 | 29篇 |
皮肤病学 | 8篇 |
神经病学 | 13篇 |
特种医学 | 69篇 |
外科学 | 13篇 |
综合类 | 8篇 |
预防医学 | 2篇 |
药学 | 28篇 |
中国医学 | 2篇 |
肿瘤学 | 7篇 |
出版年
2020年 | 1篇 |
2019年 | 2篇 |
2017年 | 2篇 |
2016年 | 4篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 12篇 |
2012年 | 7篇 |
2011年 | 3篇 |
2010年 | 14篇 |
2009年 | 15篇 |
2008年 | 1篇 |
2007年 | 5篇 |
2006年 | 10篇 |
2005年 | 5篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 10篇 |
1998年 | 16篇 |
1997年 | 13篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1986年 | 6篇 |
1985年 | 9篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1939年 | 1篇 |
排序方式: 共有256条查询结果,搜索用时 421 毫秒
121.
122.
While our Y2K worries about old computers “retiring” at midnight captured the television and news media attention, a more significant “old age” phenomenon snuck onto the scene with hardly a headline: the dawn of the age of the aged.1 The over burdened health care system will face a worldwide wave of retirees who will live longer, cost more to treat, and demand new goods and services to help them stay healthy, active, and independent. Research in persuasive technologies and the associated usage of a computing system, device, or application intentionally designed to change a person's attitude or behavior in a predetermined way is showing the potential to assist in improving healthy living, reduce the costs on the health care system, and allow the aged to maintain a more independent life. This article gives a deeper insight into the evolution of persuasive technologies and presents a framework that can guide a researcher or practitioner in comprehending more effectively the work being done in this novel research field. It also provides categories of domains within health care in which these technologies are used and surveys exemplars from published literature. The article's goal is to provide greater understanding by addressing the challenges that lie ahead for all key stakeholders that design and/or use persuasive technologies in health care. 相似文献
123.
Tait D; Riccio M; Sittler A; Scherzinger E; Santi S; Ognibene A; Maraldi NM; Lehrach H; Wanker EE 《Human molecular genetics》1998,7(6):991-997
It has been reported that the ataxin-3 protein containing a polyglutamine
sequence in the pathological range (61-84Q) is localized within the nucleus
of neuronal cells, whereas ataxin-3 with a normal repeat length (12-37Q) is
predominantly a cytoplasmic protein. In this study, the subcellular
localization of the full-length ataxin-3 protein with a glutamine sequence
in the normal range (Q3KQ22) was analysed in two mammalian cell lines.
Using two affinity-purified polyclonal antibodies raised against the N- or
C-terminal portion of ataxin-3, the protein was detected predominantly, but
not exclusively, in the nucleus of COS-7 as well as neuroblastoma cells by
immunofluorescence and confocal laser scanning microscopy (CLSM). The
distribution of the protein in these cellular compartments was confirmed by
biochemical subcellular fractionations. Furthermore, CLSM revealed that the
ataxin- 3 protein present in the nucleus of neuroblastoma cells is
associated with the inner nuclear matrix. Our results taken together with
the finding of a nuclear localization signal in ataxin-3 indicate that the
ataxin-3 protein per se translocates to the nucleus and that an expanded
glutamine repeat is not essential for this transport.
相似文献
124.
125.
126.
EE Ekanem KI Eyong EE Philip-Ephraim ME Eyong EB Adams AA Asindi 《African health sciences》2013,13(4):1170-1173
Background
Rabies is a preventable zoonosis with the highest case fatality of any disease in the world. In the developing world, it is transmitted mainly by dog bites. In parts of southern Nigeria, dog meat is a delicacy.Objective
To highlight trade in stray dogs as a major risk factor for rabies in animals and humans in south-south Nigeria.Method
Patients admitted into the University of Calabar Teaching Hospital (UCTH) with a diagnosis of rabies between July and October 2012 were analysed for risk factors, post exposure prophylaxis (PEP), health seeking behaviour and outcome. Focused group interview were also conducted among traders/handlers of stray dogs.Results
Ten cases of rabies in subjects aged 3 to 52 years were recorded in these five months period. Eight of the cases were male and apparently got infected directly or indirectly through the trade in stray dogs for human consumption. None had proper PEP and all patients died.Conclusion
Stray dog trade, fuelled by eating of dog meat, is a risk factor for human and animal rabies in Calabar, southern Nigeria. Culling of stray dogs, control of stray dogs'' trade and public enlightenment on PEP is recommended. 相似文献127.
128.
129.
BACKGROUND: Anticholinergics and beta2-agonists have generally been considered equivalent choices for bronchodilation in chronic obstructive pulmonary disease (COPD). OBJECTIVE: To assess the safety and efficacy of anticholinergics and beta2-agonists in COPD. DESIGN: We comprehensively searched electronic databases from 1966 to December 2005, clinical trial websites, and references from selected reviews. We included randomized controlled trials of at least 3 months duration that evaluated anticholinergic or beta2-agonist use compared with placebo or each other in patients with COPD. MEASUREMENTS: We evaluated the relative risk (RR) of exacerbations requiring withdrawal from the trial, severe exacerbations requiring hospitalization, and deaths attributed to a lower respiratory event. RESULTS: Pooled results from 22 trials with 15,276 participants found that anticholinergic use significantly reduced severe exacerbations (RR 0.67, confidence interval [CI] 0.53 to 0.86) and respiratory deaths (RR 0.27, CI 0.09 to 0.81) compared with placebo. Beta2-agonist use did not affect severe exacerbations (RR 1.08, CI 0.61 to 1.95) but resulted in a significantly increased rate of respiratory deaths (RR 2.47, CI 1.12 to 5.45) compared with placebo. There was a 2-fold increased risk for severe exacerbations associated with beta2-agonists compared with anticholinergics (RR 1.95, CI 1.39 to 2.93). The addition of beta2-agonist to anticholinergic use did not improve any clinical outcomes. CONCLUSION: Inhaled anticholinergics significantly reduced severe exacerbations and respiratory deaths in patients with COPD, while beta2-agonists were associated with an increased risk for respiratory deaths. This suggests that anticholinergics should be the bronchodilator of choice in patients with COPD, and beta2-agonists may be associated with worsening of disease control. 相似文献
130.
Alan S. Pearlman MD FACC J.Geoffrey Stevenson MD Donald W. Baker EE 《The American journal of cardiology》1980,46(7):1256-1262
On the basis of principles that are similar to (but differ slightly from) those that underlie M mode and two dimensional techniques, pulsed Doppler echocardiography permits evaluation of intracardiac blood flow noninvasively. This technique is helpful in the diagnosis and management of patients with valvular and congenital heart disease, and in some circumstances provides information not available from M mode or two dimensional imaging. Despite several notable limitations, pulsed Doppler echocardiography is a useful diagnostic technique whose clinical application is likely to increase as future technologic improvements occur. 相似文献