全文获取类型
收费全文 | 6569篇 |
免费 | 322篇 |
国内免费 | 63篇 |
专业分类
耳鼻咽喉 | 164篇 |
儿科学 | 123篇 |
妇产科学 | 41篇 |
基础医学 | 780篇 |
口腔科学 | 136篇 |
临床医学 | 459篇 |
内科学 | 1609篇 |
皮肤病学 | 57篇 |
神经病学 | 507篇 |
特种医学 | 243篇 |
外科学 | 1373篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 264篇 |
眼科学 | 44篇 |
药学 | 261篇 |
中国医学 | 6篇 |
肿瘤学 | 853篇 |
出版年
2024年 | 6篇 |
2023年 | 46篇 |
2022年 | 80篇 |
2021年 | 149篇 |
2020年 | 85篇 |
2019年 | 117篇 |
2018年 | 166篇 |
2017年 | 125篇 |
2016年 | 194篇 |
2015年 | 184篇 |
2014年 | 253篇 |
2013年 | 269篇 |
2012年 | 449篇 |
2011年 | 492篇 |
2010年 | 309篇 |
2009年 | 269篇 |
2008年 | 410篇 |
2007年 | 443篇 |
2006年 | 466篇 |
2005年 | 453篇 |
2004年 | 436篇 |
2003年 | 390篇 |
2002年 | 336篇 |
2001年 | 60篇 |
2000年 | 54篇 |
1999年 | 71篇 |
1998年 | 100篇 |
1997年 | 55篇 |
1996年 | 65篇 |
1995年 | 55篇 |
1994年 | 43篇 |
1993年 | 47篇 |
1992年 | 30篇 |
1991年 | 21篇 |
1990年 | 34篇 |
1989年 | 17篇 |
1988年 | 20篇 |
1987年 | 15篇 |
1986年 | 15篇 |
1985年 | 10篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 8篇 |
1980年 | 20篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1969年 | 5篇 |
排序方式: 共有6954条查询结果,搜索用时 31 毫秒
81.
Seiji Kawakita Ryuichi Aibara Yuji Kawamura Eiji Yumoto Junzo Desaki 《The Laryngoscope》1998,108(3):398-402
The authors investigated the process of denervation and reinnervation of the interarytenoid (IA) muscle in the guinea pig using transmission electron microscopy and glycogen depletion technique after unilateral transection of the recurrent laryngeal nerve (RLN) and superior laryngeal nerve to clarify the innervation pattern of the unpaired IA muscle. Anastomosis between the bilateral arytenoid branches was confirmed in the belly of the IA muscle. Five weeks after transection, all of the IA muscle fibers appeared to have been reinnervated by the contralateral RLN. As the arytenoid branch of the RLN runs together with that of the contralateral RLN in a single intramuscular nerve funiculus, it is possible that collateral sprouting branches grow and extend into the adjacent denervated Schwann's sheaths. The authors conclude that the unpaired IA muscle, as a whole, receives specific motor nerve supply from the bilateral RLNs, although each muscle fiber is innervated unilaterally. 相似文献
82.
Targeted Gene Transfer for Adenocarcinoma Using a Combination of Tumor-specific Antibody and Tissue-specific Promoter 总被引:2,自引:0,他引:2
Shuji Kurane John C. Krauss Eiji Watari Reiji Kannagi Alfred E. Chang Shoji Kudoh 《Cancer science》1998,89(11):1212-1219
We have developed a highly specific gene transfer method for adenocarcinoma using a monoclonal antibody against tumor-specific antigen coupled with a plasmid containing the carcinoembryonic antigen (CEA)-specific promoter. The chimeric CEA promoter (CC promoter), which contained an enhancer from the immediate early gene of cytomegalovirus and the CEA promoter, achieved 4- to 5-fold higher transgene expression in CEA-producing cells than the original CEA promoter while maintaining CEA specificity. Furthermore, a complex of a monoclonal antibody against Lewis Y antigen (LYA), the CC promoter-containing plasmid and cationic liposomes (DOTAP) achieved specific gene expression in CEA-producing and LYA-positive adenocarcinoma cell lines that was 200-fold more efficient than in CEA-non-producing and LYA-negative cell lines during a short in vitro incubation. This strategy may be applicable for clinical gene therapy. 相似文献
83.
Thallium-201 SPECT with triple-headed gamma camera for differential diagnosis of small pulmonary nodular lesion 20 mm in diameter or smaller 总被引:1,自引:0,他引:1
AIM: Although thallium-201 (201Tl) has been used for the diagnosis of lung cancer, its detectability of small pulmonary nodules is not known. The aim of this study was to evaluate the ability of 201Tl SPECT for the differential diagnosis for the pulmonary nodules 20 mm in diameter or smaller. METHODS: 201Tl SPECT was performed in 31 patients suspected of having primary lung cancer. The final diagnosis was established by histology, and tumor size was 10 to 20 mm in diameter. Twenty of 31 patients had malignant tumors, including squamous cell lung cancer (n = 5), adenocarcinoma (n = 14) and small cell lung cancer (n = 1), but in none of them was there mediastinal lymphnode involvement. RESULTS: Ten of 20 malignant tumors and 1 of 11 benign lesions demonstrated significant 201Tl uptake, so that the positive predictive value, negative predictive value, sensitivity and specificity for the diagnosis of lung cancer were 90.9% (10/11), 50.0% (10/20), 50.0% (10/20) and 90.9% (10/11), respectively. CONCLUSION: These data suggest that sensitivity for detecting lung cancer 20 mm or less in diameter may be insufficient, but even in patients with small pulmonary nodules, a positive 201Tl result is highly predictive of lung cancer. 相似文献
84.
Methanol is a widely used solvent and a potential fuel for motor vehicles. Human kinetic data of methanol are sparse. As a basis for biological exposure monitoring and risk assessment, we studied the inhalation toxicokinetics of methanol vapor in four female and four male human volunteers during light physical exercise (50 W) in an exposure chamber. The relative uptake of methanol was about 50% (range 47-53%). Methanol in blood increased from a background level of about 20 to 116 and 244 microM after 2 h exposure at 0, 100 ppm (131 mg/m3) and 200 ppm (262 mg/m3), respectively. Saliva showed substantially higher levels than blood immediately after exposure. This difference disappeared in a few minutes; thereafter the concentrations and time courses in blood, urine, and saliva were similar, with half times of 1.4, 1.7, and 1.3 h, respectively. The postexposure decrease of methanol in exhaled air was faster, with a half time of 0.8 h. The methanol concentrations were approximately twice as high in all four types of biological samples at 200 compared to 100 ppm. No increase in urinary formic acid was seen in exposed subjects. Our study indicates non-saturated, dose-proportional kinetics of methanol up to 200 ppm for 2 h. No gender differences were detected. Similar, parallel patterns were seen with regard to the methanol time courses in blood, urine, and saliva, whereas the concentration in exhaled air decreased markedly faster. Thus, apart from blood and urine, saliva also seems suitable for biomonitoring of methanol exposure. 相似文献
85.
Eiji Suzuki Veena Kapoor Arminder Singh Jassar Larry R Kaiser Steven M Albelda 《Clinical cancer research》2005,11(18):6713-6721
PURPOSE: Myeloid suppressor (Gr-1(+)/CD11b(+)) cells accumulate in the spleens of tumor-bearing mice where they contribute to immunosuppression by inhibiting the function of CD8(+) T cells and by promoting tumor angiogenesis. Elimination of these myeloid suppressor cells may thus significantly improve antitumor responses and enhance effects of cancer immunotherapy, although to date few practical options exist. EXPERIMENTAL DESIGN: The effect of the chemotherapy drug gemcitabine on the number of (Gr-1(+)/CD11b(+)) cells in the spleens of animals bearing large tumors derived from five cancer lines grown in both C57Bl/6 and BALB/c mice was analyzed. Suppressive activity of splenocytes from gemcitabine-treated and control animals was measured in natural killer (NK) cell lysis and Winn assays. The impact of myeloid suppressor cell activity was determined in an immunogene therapy model using an adenovirus expressing IFN-beta. RESULTS: This study shows that the chemotherapeutic drug gemcitabine, given at a dose similar to the equivalent dose used in patients, was able to dramatically and specifically reduce the number of myeloid suppressor cells found in the spleens of animals bearing large tumors with no significant reductions in CD4(+) T cells, CD8(+) T cells, NK cells, macrophages, or B cells. The loss of myeloid suppressor cells was accompanied by an increase in the antitumor activity of CD8(+) T cells and activated NK cells. Combining gemcitabine with cytokine immunogene therapy using IFN-beta markedly enhanced antitumor efficacy. CONCLUSIONS: These results suggest that gemcitabine may be a practical strategy for the reduction of myeloid suppressor cells and should be evaluated in conjunction with a variety of immunotherapy approaches. 相似文献
86.
Edgard Eduard Engel MD PhD María Sol Brassesco PhD Elvis Terci Valera MD PhD Marcello Henrique Nogueira‐Barbosa MD PhD Maurício Eiji de Almeida Santos Yamashita MD Carlos Alberto Scrideli MD PhD Luiz Gonzaga Tone MD PhD 《Pediatric blood & cancer》2012,59(7):1320-1323
Malignant triton tumor (MTT) is an aggressive peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Less than 100 cases have been described, being mostly male children with type 1 neurofibromatosis. We report a 6‐year‐old female with MTT and no diagnostic criteria for neurofibromatosis type 1. Cytogenetic analysis showed a 46,X,‐X[4]/46,XX[16] karyotype. She underwent a transfemoral amputation and chemotherapy and is free of disease 15 months after diagnosis. The few cytogenetic studies of MTT described in the literature have been inconclusive. Further cytogenetic analyses are needed to understand the role of chromosome X monosomy in the pathogenesis of this rare tumor. Pediatr Blood Cancer 2012; 59: 1320–1323. © 2012 Wiley Periodicals, Inc. 相似文献
87.
88.
89.
Keisuke Nagai Keigo Osuga Eiji Kashiwagi Shinya Kosai Hidenari Hongyo Kaishu Tanaka Yusuke Ono Hiroki Higashihara Noriyuki Tomiyama 《Journal of vascular and interventional radiology : JVIR》2021,32(7):1002-1008
PurposeTo investigate and compare venous sac and feeding artery embolization (VFE) with feeding artery embolization (FAE) alone for treatment of pulmonary arteriovenous malformations (PAVMs), based on difference in outcomes in decrease of the size of the draining vein.Materials and MethodsTwenty-six patients (7 male and 19 female; median age [interquartile range], 58 years [46–65 years]) with 42 simple PAVMs treated with coil embolization between August 2005 and December 2018 were retrospectively evaluated. Twenty PAVMs were treated with FAE early in the study period and compared with 22 PAVMs treated with VFE later in the study period. Follow-up computed tomography images obtained 8–20 months after embolotherapy were used for outcome analysis. Data related to patient demographics; follow-up period; baseline diameters of the feeding artery, venous sac, and draining vein; draining vein diameter after treatment; and decrease in the size of the draining vein, including the number reaching a threshold of 70% decrease, were compared between the 2 groups.ResultsThe draining vein decreased in size by a median of 46.4% in the FAE group and 66.3% in the VFE group, and the difference between the 2 groups was statistically significant (P = .009). There were no significant differences in the other parameters.ConclusionsVFE leads to a greater decrease in the size of the draining vein than FAE, suggesting that VFE results in more complete occlusion than FAE for treatment of PAVMs. 相似文献
90.