全文获取类型
收费全文 | 6569篇 |
免费 | 322篇 |
国内免费 | 63篇 |
专业分类
耳鼻咽喉 | 164篇 |
儿科学 | 123篇 |
妇产科学 | 41篇 |
基础医学 | 780篇 |
口腔科学 | 136篇 |
临床医学 | 459篇 |
内科学 | 1609篇 |
皮肤病学 | 57篇 |
神经病学 | 507篇 |
特种医学 | 243篇 |
外科学 | 1373篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 264篇 |
眼科学 | 44篇 |
药学 | 261篇 |
中国医学 | 6篇 |
肿瘤学 | 853篇 |
出版年
2024年 | 6篇 |
2023年 | 46篇 |
2022年 | 80篇 |
2021年 | 149篇 |
2020年 | 85篇 |
2019年 | 117篇 |
2018年 | 166篇 |
2017年 | 125篇 |
2016年 | 194篇 |
2015年 | 184篇 |
2014年 | 253篇 |
2013年 | 269篇 |
2012年 | 449篇 |
2011年 | 492篇 |
2010年 | 309篇 |
2009年 | 269篇 |
2008年 | 410篇 |
2007年 | 443篇 |
2006年 | 466篇 |
2005年 | 453篇 |
2004年 | 436篇 |
2003年 | 390篇 |
2002年 | 336篇 |
2001年 | 60篇 |
2000年 | 54篇 |
1999年 | 71篇 |
1998年 | 100篇 |
1997年 | 55篇 |
1996年 | 65篇 |
1995年 | 55篇 |
1994年 | 43篇 |
1993年 | 47篇 |
1992年 | 30篇 |
1991年 | 21篇 |
1990年 | 34篇 |
1989年 | 17篇 |
1988年 | 20篇 |
1987年 | 15篇 |
1986年 | 15篇 |
1985年 | 10篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 8篇 |
1980年 | 20篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1969年 | 5篇 |
排序方式: 共有6954条查询结果,搜索用时 15 毫秒
121.
Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function 总被引:2,自引:0,他引:2
Nagasaki T Inaba M Jono S Hiura Y Tahara H Shirakawa K Onoda N Ishikawa T Ishimura E Nishizawa Y 《European journal of endocrinology / European Federation of Endocrine Societies》2005,152(3):347-353
Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes an increase in serum OPG, and to determine whether levothyroxine (L-T4) replacement therapy might suppress serum OPG levels in hypothyroid patients. Fifty-three hypothyroid patients with chronic thyroiditis and age- and sex-matched normal control subjects were examined for the levels of serum OPG and plasma von Willebrand factor (vWF), a vascular injury marker. Thirty-seven of the hypothyroid patients were further monitored for changes in these markers during 1 year in a euthyroid state induced by L-T4 replacement therapy. Baseline OPG was significantly higher in hypothyroid patients than in normal controls (4.51 +/- 0.50 vs 3.72 +/- 0.23 pmol/l (mean +/- S.E.); P = 0.0182). In multivariate analysis, baseline OPG was significantly associated with baseline levels of TSH (r = 0.280, P = 0.0162) and vWF (r = 0.626, P < 0.0001). During one year of L-T4 replacement therapy, hypothyroid patients showed a significant decrease in OPG levels from 4.35 +/- 0.51 to 3.48 +/- 0.26 pmol/l (P = 0.0166), a level comparable to normal controls. The change in serum OPG levels during L-T4 replacement therapy was significantly and independently associated in a negative fashion with baseline vWF (r = -0.503, P = 0.0014). This study suggested that the severity of hypothyroidism and vascular injury might have important independent roles in increasing the serum OPG level in hypothyroid patients. Furthermore, it was demonstrated that a sustained euthyroid state might have the potential to decrease the serum OPG level in hypothyroid patients and that the degree of vascular injury in the hypothyroid state is independently associated with a decrease in serum OPG during a 1-year normalization of thyroid function. 相似文献
122.
123.
Kazuhito Nomura Sonoko Sakawaki Eiji Sakawaki Ayumu Yamaoka Wakiko Aisaka Hiroyuki Okamoto Yoshihiro Takeyama Shuji Uemura Eichi Narimatsu 《Medicine》2021,100(19)
Introduction:Malignant catatonia (MC) is a movement disorder syndrome characterized by immobility, rigidity, and consciousness disorders that develops in association with mental and physical diseases. It is often fatal due to hyperthermia, rhabdomyolysis, and acute kidney injury. Its clinical symptoms are similar to those of another disorder, neuroleptic malignant syndrome (NMS), and it is often difficult to distinguish between the 2 disorders.Patient concerns:An Asian woman in her 60s with history of schizophrenia. She was admitted to our hospital because of symptoms such as fever, unconsciousness, and muscle rigidity. Blood tests showed kidney injury and high creatinine kinase levels.Diagnoses:At the time of admission, she had been diagnosed with NMS complicated by pulmonary aspergillosis and was undergoing treatment although there was no improvement.Interventions:Subsequently, the administration of propofol, a gamma-aminobutyric acid A agonist, markedly improved the symptoms, and the diagnosis was corrected to MC. At the beginning of her hospitalization, she received dantrolene, bromocriptine, amantadine, and L-3,4-dihydroxyphenylalanine as treatment for NMS, but her symptoms did not improve. With propofol, which is used for sedation, her catatonic symptoms improved markedly. Quetiapine administration further improved the symptoms, and it eventually resolved completely.Outcomes:The patient''s MC was in remission. Prolonged intensive care management resulted in a decline in activities of daily living, and she required rehabilitation at another hospital.Conclusion:This is the first report of MC with suspected involvement of pulmonary aspergillosis. MC differs from NMS, in that it is treated more effectively with gamma-aminobutyric acid A agonists. Although benzodiazepines are the first choice for the diagnosis and treatment of MC, they are ineffective for majority of patients with schizophrenia. However, even in such cases, propofol and quetiapine are effective, and they facilitate diagnosis and treatment. 相似文献
124.
125.
Koji Fukushima Yoshiyuki Ueno Hirokazu Kanegane Yoko Yamagiwa Jun Inoue Osamu Kido Futoshi Nagasaki Takayuki Kogure Eiji Kakazu Yu Nakagome Yasunori Matsuda Noriyuki Obara Osamu Kimura Tooru Shimosegawa 《Hepatology research》2008,38(4):415-420
Severe hepatitis with an indistinct etiology manifested in a 16-year-old boy who had no particular history. The histological features of the liver and clinical course of the patient were similar to those of patients with autoimmune hepatitis characterized by interface hepatitis and severe lobular inflammation of the liver and recurrent exacerbations of hepatitis. We administered intravenous glycyrrhizin preparation daily or three times a week combined with the oral administration of ursodeoxycholic acid daily throughout the term after the initial onset of disease for the control of disease activity. The normalization of the concentration of alanine aminotransferase in serum was achieved in response to the therapy during the course. The serum concentration of immunoglobulins of the patient gradually decreased from the onset of the disease to an unacceptable level without globulin preparation during the following period of 17 months. Immunological tests revealed impairment of immunoglobulin production bythe B cell population of the patient, which led to the diagnosis of the patient as common variable immunodeficiency (CVID). The patient, with improved liver histology after 27 months from the onset of disease, benefited from the current combination therapy without severe infection through the avoidance of overimmunosuppression. CVID is defined as a heterogeneous syndrome characterized by various degrees of hypogammaglobulinemia without any specific predisposing causes, frequently associated with autoimmunity. Diagnostic criteria and therapeutic options of persistent hepatitis with CVID are to be established, as discussed in the current report. 相似文献
126.
Sugimoto Y Nishii K Sakakura M Araki H Usui E Lorenzo V F Hoshino N Miyashita H Ohishi K Katayama N Shiku H 《The hematology journal : the official journal of the European Haematology Association / EHA》2004,5(1):84-89
We report a 31-year-old female with t(8;21)(q22;q22) acute myeloid leukemia (AML), M2 in the FAB classification. Complete remission was achieved with daunorubicin and cytarabine induction therapy followed by three courses of high-dose cytarabine consolidation. Only 3 months later, the patient relapsed with granulocytic sarcomas (GSs) in her rhinopharynx, external acoustic meatus, and bone marrow. She received focal radiation for the GSs and successfully underwent reinduction chemotherapy. Subsequently, she received a matched related donor peripheral blood stem cell transplantation followed by high-dose chemotherapy and is now in a second remission. We summarized 79 reported cases of t(8;21) AML with GS and reviewed the literature to identify differences in the characteristics of t(8;21) AML with GS between adults and children. To our knowledge, this is the first report of pharyngeal GS in t(8;21) AML, and focal irradiation plus more intensive postinduction therapy during first remission, such as allogeneic-SCT, may be effective in adult t(8;21) AML patients with GS. 相似文献
127.
Life‐threatening hemorrhage from the corona mortis after laparoscopic inguinal hernia repair: Report of a case 下载免费PDF全文
Tomohiko Yasuda Akihisa Matsuda Masao Miyashita Satoshi Matsumoto Nobuyuki Sakurazawa Youichi Kawano Kumiko Sekiguchi Fumihiko Ando Takeshi Matsutani Eiji Uchida 《Asian journal of endoscopic surgery》2018,11(2):169-172
Along with the increased use of other laparoscopic procedures, laparoscopic inguinal hernia repair has become widely used because of its minimally invasive nature. Here, we report a case of 66‐year‐old man who underwent transabdominal preperitoneal laparoscopic hernioplasty and developed hemorrhagic shock on postoperative day 1. CT showed postoperative venous hemorrhage from the retropubic space. Successful hemostasis of the massive hemorrhage was achieved laparoscopically. The origin of the hemorrhage was assumed to be the corona mortis vein, which was slightly injured during the operation. Despite the rarity of this complication, surgeons must be aware of the need to carefully dissect and fix the mesh in the retropubic space to avoid injuring the corona mortis. Laparoscopic hemostasis may be an effective alternative to the open approach. 相似文献
128.
Tomoo Yamazaki Satoru Joshita Eriko Kasuga Kazuki Horiuchi Ayumi Sugiura Naoyuki Fujimori Michiharu Komatsu Takeji Umemura Akihiro Matsumoto Eiji Tanaka 《Journal of infection and chemotherapy》2018,24(5):393-397
A 73-year-old woman was admitted with consciousness disturbance following a fever. Abdominal computed tomography revealed a large liver abscess with which the presence of Desulfovibrio desulfuricans and Escherichia coli was confirmed by thorough blood and abscess content culture. Empiric meropenem treatment was switched to cefoperazone/sulbactam, followed by ampicillin/sulbactam based on susceptibility testing. Desulfovibrio desulfuricans is a common bacterium that rarely causes liver abscess and may be overlooked during co-infection due to overgrowth of the accompanying bacteria. Clinicians should bear Desulfovibrio desulfuricans in mind and select the appropriate antibiotics according to susceptibility testing when anaerobic bacteria are detected in a liver abscess. 相似文献
129.
130.
Limaprost or Pregabalin: Preoperative and Postoperative Medication for Pain due to Lumbar Spinal Stenosis 下载免费PDF全文
Yuji Kasukawa MD PhD Naohisa Miyakoshi MD PhD Takashi Kobayashi MD PhD Kazuma Kikuchi MD PhD Kunio Ebata MD PhD Noriyuki Ishikawa MD PhD Tetsuya Suzuki MD PhD Hiroshi Sasaki MD PhD Yuji Hatakeyama MD PhD Michio Hongo MD PhD Yoshinori Ishikawa MD PhD Daisuke Kudo MD PhD Toshiki Abe MD PhD Koichiro Okuyama MD PhD Tadato Kido MD PhD Mitsuho Chiba MD PhD Toyohito Segawa MD PhD Masazumi Suzuki MD Takashi Mizutani MD Ryota Kimura MD Yuichi Ono MD Jumpei Iida MD Eiji Abe MD PhD Yoichi Shimada MD PhD 《Pain practice》2018,18(5):625-630