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981.
Hirofumi Hagino Eiichi Tabuchi Masayoshi Kurachi Osamu Saitoh Yueji Sun Takashi Kondoh Taketoshi Ono Kunio Torii 《Brain research》1998,813(2):1
The effects of D2 dopamine receptor agonist, bromocriptine (BROMO), and antagonist, haloperidol (HPD), on brain activity were investigated in rats by functional magnetic resonance imaging. T2*-weighted signal intensity was increased in the hypothalamus at 120 min after acute administration of BROMO, and in the ventral posterior and dorsomedial nuclei of the thalamus from 30 to 120 min. In contrast, the signal intensity was decreased in the caudate–putamen at 30 min after acute administration of HPD, in the hypothalamus from 30 to 60 min, and in the perirhinal cortex at 30 min. After chronic (2 weeks) HPD treatment, acute administration of HPD decreased signal intensity in the caudate–putamen at 60 min, in the hypothalamus at 30 min, the perirhinal cortex from 2 to 120 min, the dorsomedial and ventral posterior nuclei of the thalamus from 2 to 120 min, and the medial nucleus of the amygdala from 60 to 120 min. These results suggest that (1) the D2 receptor agonist increased the activity of the thalamic nuclei and the hypothalamus, while the D2 receptor antagonist suppressed brain activity in the regions where D2 receptors were present, (2) the suppression of brain activity in the thalamic nuclei and the perirhinal cortex by acute HPD administration was enhanced by chronic HPD treatment, and (3) the effects of antipsychotic drugs on the thalamus, amygdala, and perirhinal cortex may be related to their therapeutic efficacy, since clinical improvement in schizophrenic patients appears several days after the start of HPD treatment. 相似文献
982.
Kiyomi Matsumiya Masaya Kitamura Hidefumi Kishikawa Nobuyuki Kondoh Yoshitomo Fujiwara Mikio Namiki Akihiko Okuyama 《International journal of urology》1998,5(4):361-363
Background: We undertook a prospective trial to compare the efficacy and adverse effects of a gonadotropin releasing-hormone analogue (CnRHa) and clomiphene therapy for idiopathic normogonadotropic oligoasthenozoospermia (INOA).
Methods: Between January and December 1995, 44 newly-diagnosed INOA patients were randomly allocated to treatment with GnRHa or clomiphene citrate. Efficacy was assessed by measuring changes in semen parameters prior to and after 3 months of treatment. Twenty-three INOA patients underwent GnRHa therapy with 15 μg of diluted buserelin acetate given once a day intranasally, and 21 INOA patients were treated with 50 μg of clomiphene citrate daily by oral administration.
Results: The mean sperm density in the GnRHa group increased from 1 6.1 times 106 /mL to 26.9 times 106 /ml(P < 0.05), while the mean sperm density did not change significantly in the group treated with clomiphene. Similarly, the mean sperm motility increased from 35.9% to 43.9% in the GnRHa group (P < 0.05), but did not significantly change in the clomiphene group. No adverse effects were observed in either group.
Conclusion: This GnRHa treatment protocol can be administered as an outpatient and is hoped to benefit INOA patients. 相似文献
Methods: Between January and December 1995, 44 newly-diagnosed INOA patients were randomly allocated to treatment with GnRHa or clomiphene citrate. Efficacy was assessed by measuring changes in semen parameters prior to and after 3 months of treatment. Twenty-three INOA patients underwent GnRHa therapy with 15 μg of diluted buserelin acetate given once a day intranasally, and 21 INOA patients were treated with 50 μg of clomiphene citrate daily by oral administration.
Results: The mean sperm density in the GnRHa group increased from 1 6.1 times 10
Conclusion: This GnRHa treatment protocol can be administered as an outpatient and is hoped to benefit INOA patients. 相似文献
983.
984.
Hiromu Tanaka Kazuhiro Hirohashi Yasuhiro Ohta Eiji Kimura Taichi Shuto Akishige Kanazawa Takatsugu Yamamoto Hiroaki Kinoshita 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(4):451-456
Hilar bile duct carcinoma has a poor prognosis, but this has been improved in recent years by an aggressive surgical approach.
We treated a 73-year-old woman who had obstructive jaundice due to bile duct carcinoma at the hepatic hilum. The jaundice
decreased after percutaneous transhepatic biliary drainage. The tumor was resected with the left and caudate lobe of the liver
and a part of portal vein. The right hepatic artery was located behind the common hepatic duct, and was suspected to be invaded
by the tumor. We dissected the tumor from the arterial wall without carrying out combined resection of the hepatic artery.
On the 6th postoperative day, the hepatic artery ruptured and the patient suffered hypovolemic shock. Resection of the hepatic
artery and reconstruction were done, but the patient died 2 days later. Histological examination of the resected artery showed
that the tumor had been curatively removed by dissection and that no tumor remained at the arterial wall. The rupture of the
right hepatic artery was thought to have been caused by damage to the wall during the dissection procedure. 相似文献
985.
Approximate entropy of the electroencephalogram in healthy awake subjects and absence epilepsy patients. 总被引:1,自引:0,他引:1
Naoto Burioka Germaine Cornélissen Yoshihiro Maegaki Franz Halberg Daniel T Kaplan Masanori Miyata Yasushi Fukuoka Masahiro Endo Hisashi Suyama Yutaka Tomita Eiji Shimizu 《Clinical EEG and neuroscience》2005,36(3):188-193
The approximate entropy (ApEn) of signals in the electroencephalogram (EEG) was evaluated in 8 healthy volunteers and in 10 patients with absence epilepsy, both during seizure-free and seizure intervals. We estimated the nonlinearity of each 3-sec EEG segment using surrogate data methods. The mean (+/- SD) ApEn in EEG was 0.83 +/- 0.22 in healthy subjects awake with eyes closed. It was significantly lower during epileptic seizures (0.48 +/- 0.05) than during seizure-free intervals (0.80 +/- 0.13) (P < 0.001). Nonlinearity was clearly detected in EEG signals from epileptic patients during seizures but not during seizure-free intervals or in EEG signals from healthy subjects. The ApEn of EEG signals estimated over consecutive intervals could serve to determine pathological brain activity such as that occurring during absence epilepsy. 相似文献
986.
Masayuki Shiraishi Takashi Oshiro Eiji Nozato Masayoshi Nagahama Kaoru Taira Hironori Nomura Hideki Sugawa Yoshihiro Muto 《Transplant international》2002,15(5):212-219
In this study, the adenovirus-mediated gene transfer of triple human complement regulating proteins was investigated in xenogeneic pig liver perfusion. The porcine liver was perfused in situ at 4 degrees C under a pump-driven veno-venous shunt of the portal vein and inferior vena cava, with 5 to 15x10(11) plaque-forming units (pfu) of adenovirus vector (group 1: AxCALacZ; 2: AxCACD59; 3: AxCACD59 + AxCADAF; 4: AxCACD59 + AxCADAF + AxCAMCP) for 1 h (for each, n=3). The livers were harvested 24 h after gene transfer and then were reperfused ex-vivo with fresh human blood for 2 h. In immunohistochemical staining, each complement regulating protein (CRP) showed a distribution similar to that of the LacZ expression. The C3 levels in the perfusate were also maintained at higher levels in group 4 from 60 to 120 min after reperfusion (C3: 85% to 95% of the initial level) than in groups 1 to 3 (C3: 80% to 90% of the initial level) from 60 to 120 min after reperfusion. The complement deposition on the porcine liver [C3, membrane attack component (MAC)] decreased significantly more in group 4 than in groups 1 to 3. In conclusion, the adenovirus-mediated multiple gene transfer of human CRPs (hCRPs) was found to effectively suppress the complement activation in xenogeneic pig liver perfusion. 相似文献
987.
Eiji Itoi Lawrence J. Berglund John J. Grabowski Fredrick M. Schultz Eric S. Growney Bernard F. Morrey Kai-Nan An 《Journal of orthopaedic research》1995,13(4):578-584
The tensile properties of the supraspinatus tendon were investigated in 11 shoulders from fresh cadavers. The tendon was divided into three longitudinal strips: anterior, middle, and posterior. Each specimen was mounted on a materials testing machine, with four fluorescent markers placed on both surfaces of the tendon strip. The positions of these markers were recorded during the test by two synchronized video cameras. Load-deformation and strain curves were determined, and the stress-strain curve, strength, and modulus of elasticity were calculated. The posterior strip was thinner in cross section than the others (p = 0.0355). The ultimate load and ultimate stress were significantly greater in the anterior strip (16.5 ±7.1 MPa) than in the middle (6.0 ± 2.6 MPa) and posterior (4.1 ± 1.3 MPa) strips (p < 0.0001). The modulus of elasticity also was significantly greater in the anterior strip (p < 0.0001), but there was no significant difference between the superficial and deep surfaces. It is concluded that the anterior portion of the supraspinatus tendon is mechanically stronger than the other portions, and it seems to perform the main functional role of the tendon. 相似文献
988.
The safety of the Fettweis squatting position for immobilization after reduction in congenital dislocation of the hip was evaluated in an experimental model in pigs. In seven neonatal pigs, the hips were fixed in a plaster cast for 3 h in the Fettweis squatting position after the insertion of an allogenic meniscus into the hip joint. Three to 5 months later, no obvious deformity of the femoral head or neck was noted. The results demonstrate that the squatting position is an appropriate position for immobilization after the reduction of dislocated hip joints. 相似文献
989.
Morimasa Amemiya Eiji Kusano Shigeaki Muto Kaoru Tabei Yasuhiro Ando Robert J Alpern Yasushi Asano 《Experimental nephrology》2002,10(1):26-33
BACKGROUND: We previously found that the Na(+)/H(+) exchanger 3 (NHE3) is localized in the apical membrane of the rat renal proximal tubule and thick ascending limb of Henle. In the present study, we examined the direct effect of glucagon on the opossum kidney P (OKP) cell Na(+)/H(+) antiporter, encoded by NHE3. METHODS: Na(+)/H(+) antiporter activity was measured as the rate of cell pH recovery from an acid load using 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. Northern blot and Western blot analyses were performed using OKP NHE3 cDNA and anti-OKP-NHE3 antibodies. RESULTS: Glucagon (1 ng/ml) acutely (1 h) inhibited, but chronically (24 h) activated NHE3 activity in OKP cells. These effects were blocked by either KT5720 or RpcAMP [protein kinase A (PKA) inhibitors], and mimicked by 10(-4) M dibutyryl-cAMP. Both NHE3 mRNA and protein abundance increased with the 24-hour incubation in glucagon or dibutyryl-cAMP. Cycloheximide did not prevent a significant increase in NHE3 activity at 24 h. We therefore examined NHE3 protein abundance in the surface membrane by the biotinylation method. cAMP or glucagon significantly increased NHE3 protein abundance in the surface membrane when incubated with cycloheximide for 24 h. CONCLUSIONS: Glucagon acutely inhibits but chronically activates NHE3 activity in OKP cells via a PKA-dependent pathway. Both protein-synthesis-dependent and -independent mechanisms play important roles in the chronic activation of NHE3. 相似文献
990.
Fumihito Tajima Toshio Kawatani Kiyomi Ishiga Eiji Nanba Hironaka Kawasaki 《European journal of haematology》1998,60(5):289-296
Abstract: To investigate the clinical role of the soluble form of c-kit receptor (s-kit) in patients with acute myeloid leukemia (AML), we determined the levels of serum s-kit and expression of c-kit antigens and mRNA in leukemic cells. The serum s-kit level was measured using ELISA assay in 30 AML patients and 20 normal controls. C-kit antigens of leukemic blasts were stained immunohistologically, and c-kit mRNA was detected by RT-PCR. The serum s-kit level in M1 and M2 were significantly increased (p<0.01) and that in M4 or M5 was significantly decreased (p<0.05) compared to that in the controls. In the comparisons among subtypes of FAB classification, M1 and M2 showed significantly higher levels than M4 or M5 (p<0.05 and p<0.01, respectively). Both expression of c-kit antigens and mRNA were observed in M0 (1/4), M1 (2/4) and M2 (6/8), but neither was observed in M4 or M5. The serum s-kit levels were correlated with the absolute number of AML blasts in peripheral blood (r=0.564, p<0.05). These results indicate that the serum s-kit level is related to the stage of differentiation of AML blasts in accordance with the expression of c-kit protein and mRNA in AML blasts, and is useful for assessment of leukemic cell burden. 相似文献